49 results about "Naphthalene Derivative" patented technology

The invention discloses an organic electroluminescent material and an organic electroluminescent device and application thereof.The organic electroluminescent material can serve as a functional layer of the organic electroluminescent device, 9-alkyl-9-phenyl-9H-fluorene serves as a parent nucleus and is directly connected with arylamine on the parent nucleus, one side chain of the arylamine is aryl or heteroaryl, the other side chain of the arylamine is 1, 1, 4, 5, 6-tetramethyl-1, 3, 5-tetramethyl-1, 3, 5-tetramethyl-1, 3, 5-tetramethyl-1, 3, 5-tetramethyl-1, 3, 5-tetramethyl-1, 3-tetramethyl-1, 3-tetramethyl-1, 3-tetramethyl-1, 3-tetramethyl-1, 3-tetramethyl-1, 3-tetramethyl-1, 3-tetramethyl-1 Compared with other compounds, the organic electroluminescent material compound disclosed by the invention has the advantages that the transverse electric leakage is small, and the phenomena that adjacent pixels are lightened, transverse crosstalk is generated between adjacent sub-pixels and color display is influenced due to transverse leakage current of the adjacent pixels in a device can be reduced. The organic electroluminescent material is used as a functional layer of the organic electroluminescent device, and the problems that color display is affected and picture display is abnormal due to transverse electric leakage of an OLED display device can be solved.

To provide an atropisomer of a 1,1'-binaphthyl derivative that exhibits a high HTP value even in small quantities.SOLUTION: The present invention provides an atropisomer represented by, for example, a following structural formula (2.1), a polymerizable liquid crystal composition comprising the atropisomer and a polymerizable liquid crystal compound, an optical film, an image display device and an eyewear.SELECTED DRAWING: None

A quinazolinone catalyst with both N-N and C-C axis chirality and its synthesis method and application, its chemical structural formula is shown in Formula 4; Synthesis method: using indole-derived o-aminobenzamide and 1-naphthaldehyde derivative as raw materials, using molecular sieve as dehydrating agent, bromobenzene as reaction solvent, stirring for 4h under the catalysis of chiral phosphoric acid and 10°C, then adding ethyl acetate, 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, stirring for 10h under room temperature, TLC tracking reaction to complete formula 3 compound; using formula 3 compound, phenylsilane, trifluoromethanesulfonic acid as raw materials, adding toluene, stirring reaction under 100°C, TLC tracking reaction to end to obtain formula 4 compound. The catalyst prepared by the present invention can be used as a chiral ligand in transition metal-catalyzed asymmetric allylation reaction, with excellent stereoselectivity control effect; the method has mild reaction conditions, low cost and high enantioselectivity.

The present invention relates to a novel crystal of KUS121 useful as a medicament and a method for preparing said crystal.

The invention belongs to the field of chemical detection, and relates to a fluorescent probe based on naphthalene derivatives, a preparation method of the fluorescent probe and application of the fluorescent probe in pH detection. The selected fluorophore naphthalene derivative has the advantages that the raw materials are simple and easy to obtain, the emission wavelength is in a visible light region, and the Stocks displacement is large (137 nm), so that the fluorescent probe pHP1 has the advantages of low background interference, small light damage to biological samples, strong sample penetrability, good light stability, high detection sensitivity and the like.

An aromatic compound is composed of a stable isotope, in which two adjacent carbon atoms are 13C, atomic nuclei of other atoms to which the two adjacent carbon atoms are bonded have a spin quantum number of 0, and a hydrogen atom which has a spin coupling constant and is bonded to the 13C nucleus through a carbon atom is substituted with a deuterium atom. In the aromatic compound, a relaxation time of a 13C nucleus excited by a DNP device is longer than that in the related art.

The invention discloses a kind of organic electroluminescent material and organic electroluminescent device and application, the organic electroluminescent material can be used as the functional layer of organic electroluminescent device, with 9 alkyl 9 phenyl 9H fluorene as parent nucleus, directly connected to arylamine on parent nucleus, one of the side chains of arylamine is aryl or heteroaryl, and the other side chain is 1,1,4,4 tetramethyl 1,2,3,4 tetralin derivative, compared to other compounds, the organic electroluminescent material compound of the present invention has small lateral leakage, can reduce adjacent pixels in device and produce lateral leakage current, cause adjacent pixels to be lit, produce lateral crosstalk between adjacent sub-pixels, affect the phenomenon of color display. The organic electroluminescent material of the present invention is as the functional layer of organic electroluminescent device, can solve the problems such as color display and picture display abnormality affected by OLED display device lateral leakage.

The invention belongs to the technical field of biological medicines, and relates to phenyl naphthalene derivatives and application thereof in preparation of medicines for preventing and treating tumors or medicines for neuroprotection. The compound is a compound shown in a formula I or a formula II or a pharmaceutically acceptable salt thereof. In the formula I, A is not present or is carbonyl, A'is carbonyl, sulfuryl, oximido and imino, R1 is amino, nitryl, acylamino, sulfonamide, aryl methoxy, aryl ethyoxyl, fluorine atom, trifluoromethyl, ureido, amidoxime, amidino and N-methyl sulfonamide, and R2 is hydrogen atom, methoxy, amino, nitryl, acylamino, amidoxime, amidino or fluorine atom; r2 and H2N-A'are located at the adjacent position of a benzene ring, R2 or H2N-A 'is located at the para-position of phenyl, and X1 and X2 are independently selected from CH or N. The phenyl naphthalene derivative provided by the invention has relatively high NQO2 inhibitory activity, and can be used as a chemical drug for tumor treatment and a neuroprotective agent for neurological diseases.

The present invention relates to a pharmaceutically acceptable salt and a crystal form of a tetrahydronaphthalene derivative, and a preparation method. Specifically, the present disclosure provides a pharmaceutically acceptable salt and a crystal form of (S)-3-(5-(4-((1-(4-((1R,2R)-6-hydroxy-2-isobutyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenyl)piperidin-4-yl)methyl)piperazin-1-yl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione, and a preparation method therefor. The corresponding salt has good stability and can be better used for clinical treatment.

The invention discloses a chiral binaphthol-based fluorescent material as well as a preparation method and application thereof, and belongs to the technical field of organic photoelectric materials. The fluorescent material takes a chiral binaphthyl derivative as a skeleton, and a chiral binaphthyl group is introduced into a para-position position of tetrafluoroterephthalonitrile, so that a chiral space charge transfer luminescence system with a clear structure is formed. The preparation method comprises two steps of nucleophilic substitution reaction, the reaction condition is mild, the synthetic route is simple, and the yield is stable. The material has dual-state emission and aggregation enhanced luminescence characteristics, avoids aggregation quenching, has excellent circular polarization luminescence performance, has a luminescence asymmetry factor (Glum) of 3.6 * 10 <-3 >-5.9 * 10 <-3 >, and can still maintain stable chiral luminescence characteristics in a doped film. The material can be widely applied to the fields of commercial anti-counterfeiting, fluorescent ink, circular polarization luminescent devices, 3D display, information encryption, biological probes, LED light sources and the like, and has good industrial amplification potential and practical application value.

The invention belongs to the technical field of perovskite cells, and particularly discloses high-orientation perovskite, a preparation method and a solar cell prepared from the high-orientation perovskite, and the high-orientation perovskite comprises a mixture of naphthalene derivatives of sulfonic acid groups and amido, a perovskite component and a precursor solution, the mixture of naphthalene derivatives of sulfonic groups and amido is a mixture of potassium 6-hydroxy-2-naphthalene sulfonate and 6-bromo-2-naphthylamine hydrochloride, the molar mixing ratio of the potassium 6-hydroxy-2-naphthalene sulfonate to the 6-bromo-2-naphthylamine hydrochloride is 1: 0-1: 1, the perovskite component mainly comprises ABX3, and A is at least one of Cs, FA and MA; b is at least one of Pb and Sn; and X is I. According to the invention, crystal lattices are anchored through coordination of sulfonate radicals / hydroxyl radicals and Pbas, occupation of ammonium radicals on FAvacancies and the like, aromatic interaction among naphthalene rings in molecules is utilized to synergistically guide perovskite to orderly grow out of a (100) plane, inhibit lattice inclination and defect formation and regulate and control the orientation of perovskite crystals, so that the perovskite film with high orientation is obtained, and the perovskite film has good application prospects. And the photovoltaic performance of the perovskite solar cell is improved.

To provide methods and compounds for use in treating and / or preventing breast cancer, including locally advanced or metastatic, ER+, HER2- breast cancer, in a subject in need of treatment.SOLUTION: Treating and / or preventing methods are provided which comprise administering a compound of Formula (I), or a pharmaceutically acceptable salt, enantiomer, stereoisomer, solvate, polymorph, isotopic derivative, or prodrug thereof.SELECTED DRAWING: Figure 8

Compounds with magnetic properties are provided herein, which belong to the category of metal oxide nanoparticles, coated and conveniently functionalized, which are conjugated with naphthalene compounds related to agglomerates and β-amyloid plaques present in neurodegenerative diseases. These new nanoparticles (NPs) are used for the non-invasive detection of agglomerates and amyloid plaques using the Magnetic Resonance Imaging (MRI) technique. The nanoparticles described here cross the blood-brain barrier (BBB), without the use of any membrane-disrupting agent. Likewise, they bind with high affinity and specificity to the agglomerates and β-amyloid plaques, and are used as contrast agents in MRI for the early detection of Alzheimer's disease (AD).

The present invention discloses a preparation method of substituted naphthalene derivatives. The method comprises the following steps: in the presence of methyl trifluoromethanesulfonate and potassium bromide, in a solvent, reacting a compound shown by formula II with a compound shown by formula III to obtain a substituted naphthalene derivative shown by formula I. The present invention relates to a preparation method for efficiently preparing substituted naphthalene derivatives by the synergistic catalysis of an organic reagent methyl trifluoromethanesulfonate (MeOTf) and potassium bromide (KBr). The whole process does not involve metals, the substrates are convenient to obtain, the reaction conditions are mild, and the operation is simple.

The invention provides a naphthyl photoacid generator and a synthesis method thereof. The photoacid generator comprises the following structural general formula: # imgabs0 #, and in the structural general formula, R is C1-C12 alkane. The preparation method of the photoacid generator comprises the following steps: (1) carrying out nucleophilic reaction on a halogenated methylnaphthalene derivative and a sodium mercaptide derivative at different positions to prepare a methylnaphthalenesulfane derivative; and (2) preparing a sulfonium salt compound through a reaction of the methylnaphthalenesulfane derivative and the halogenated methylnaphthalene derivative, and further preparing the naphthyl photoacid generator through an ion exchange method. The prepared photoacid generator is a novel photoacid generator and has good fat solubility, and the yield and purity of the preparation method are high.

The invention belongs to the technical field of organic synthesis, and provides a multifunctional naphthalene derivative as well as a preparation method and application thereof. In the structural formula of the multifunctional naphthalene derivative, R2 is alkyl, phenyl, 2-naphthyl, 1-naphthyl, 2-thienyl, an aromatic ring connected with an electron withdrawing group or an aromatic ring connected with an electron donating group, and the electron withdrawing group and the electron donating group comprise methyl, methoxyl, trifluoromethyl or halogen; r3 is H, methyl or methoxyl; r4 is H, methyl, phenyl or alkynyl. According to the preparation method, a 1, 6-diyne-3-alcohol compound is taken as a raw material, [2-(di-tert-butylphosphine) biphenyl] gold chloride (I) and silver tetrafluoroborate are taken as catalysts, intramolecular 6-endo-dig cyclization, 3, 3-Claisen rearrangement and aromatization reaction are performed, and finally, deacylation reaction is performed to obtain the multifunctional naphthalene derivative with phenyl, phenylethynyl and naphthalene ring structures. The method has application value in multiple fields.

The invention provides a method for photocatalytic asymmetric intermolecular dearomatization cycloaddition reaction based on naphthalene derivatives, and belongs to the technical field of chemical synthesis. The olefin compound and the 2-pyrazole amide naphthalene derivative are used as reaction raw materials, [2 + 2]-cycloaddition or [4 + 2]-cycloaddition reaction is realized under specific reaction conditions, and the obtained product has high yield and high enantioselectivity. The substrate provided by the invention is good in universality, is especially suitable for raw materials containing naphthalene, overcomes the problem that naphthalene-containing compounds are not easy to react in the prior art, and has a good application prospect.

The present invention relates to dihydronaphthalene derivatives of formula D specified in claim 1; to a liquid crystalline medium comprising a compound of formula D; and to high-frequency components containing these media, in particular microwave components for high-frequency devices such as devices for phase shifting microwaves, tunable filters, tunable metamaterial structures, and electron beam controlled antennas such as phased array antennas.

To provide an aromatic compound having longer relaxation time of 13C nucleus excited by a DNP apparatus than conventional ones.SOLUTION: An aromatic compound is composed of a stable isotope. Two adjacent carbon atoms are 13C, a spin quantum number of an atomic nucleus of other atom to which the two adjacent carbon atoms are coupled is zero, and a hydrogen atom having a spin coupling constant coupled through a carbon atom to 13C nucleus is substituted by a deuterium atom.SELECTED DRAWING: None

The present invention provides methods for treating and / or preventing breast cancer, including locally advanced or metastatic ER+ and HER2- breast cancers in patients requiring treatment, compounds for use in treatment, and combinations thereof. [Solution] Administer a compound of formula (I), or a pharmaceutically acceptable salt, enantiomer, stereoisomer, solvate, polymorph, isotope derivative thereof, or a prodrug thereof. JPEG2026136114000154.jpg65134

The invention discloses synthesis of a tetrahydronaphthalene derivative and an intermediate thereof. The invention provides a synthesis method of a compound I. The synthesis method comprises the following step: in a solvent, in the presence of acid and a palladium catalyst, and in the presence of a reducing agent, carrying out hydroxyl reduction reaction on a compound IV to prepare the compound I. The preparation method has one or more of the following advantages: (1) good reaction selectivity, (2) mild and easy-to-control reaction, (3) high reaction yield, (4) good product purity, and (5) easily available materials, simple and convenient reaction operation, and good application prospect and value.

Described herein are compounds of Formula I and their pharmaceutically acceptable salts, solvates, or stereoisomers, as well as their uses (e.g., as estrogen receptor degraders).

An object of the present invention is to provide a method for preparing a compound (I), the method being suitable for an industrial preparation scale. For the purpose of preparing a high-purity compound (I) on an industrial scale, there is a need for a method for preparing the high-purity compound (I) at low cost with high yield. As a result of intensive investigations, the inventors of the present invention have found, in order to solve the above object, reaction conditions under which a geometric isomer of a double bond can be controlled and a preparation method for obtaining a desired isomer in a process for preparing the compound (II). In addition, in each preparation step, reaction conditions for obtaining a high-purity intermediate or the compound (I), post-treatment conditions for removing impurities, and crystallization conditions have been found. Further, a method for synthesizing the compound (I), the method allowing safe operation even at an industrial preparation scale has been found.

The invention discloses a multi-stimulus response light-emitting system constructed by a naphthalene derivative G1 and cucurbit [n] uril and application of the multi-stimulus response light-emitting system, and relates to the technical field of multi-stimulus response light-emitting materials. According to the multi-stimulus response light-emitting system, the naphthalene derivative G1 is taken as a core, the naphthalene derivative G1 is driven to dynamically change in a molecular accumulation mode through two stimuli of concentration internal regulation and control and cucurbituril external regulation and control, then continuous light-emitting color change from blue to yellow is generated, and the change has regularity, controllability and reversibility. The multi-stimulus response light-emitting system can convert various stimuli into diversified optical signals, and a material basis is provided for applications such as multi-level information encryption and anti-counterfeiting.

A 1, 2-dihydronaphthalene derivative copolymer synthesized based on active anion polymerization and a preparation method thereof belong to the technical field of high polymer materials, are synthesized based on an active anion polymerization mechanism, and are formed by copolymerization of a 1, 2-dihydronaphthalene derivative, a styrene derivative and a diene monomer. The 1, 2-dihydronaphthalene derivative is 1, 2-dihydronaphthalene and functionalized 1, 2-dihydronaphthalene with a substituent group on an aromatic ring or an aliphatic ring; the styrene derivative is styrene, alpha-methyl styrene, 1, 1-diphenylethylene and a chain segment formed by mutual polymerization of the monomers; the dialkene monomer is butadiene, isoprene, 2, 3-dimethyl-1, 3-butadiene and a chain segment formed by mutual polymerization of the dialkene monomer, the isoprene and the 2, 3-dimethyl-1, 3-butadiene. According to the invention, binary and ternary copolymerization of various monomers with similar structures but different performances is realized; the polymerization condition is mild, the copolymer with controllable molecular weight and distribution is easy to obtain, and the performance and application range of synthetic resin and synthetic rubber are further expanded.

The application discloses an organic electroluminescent material, an organic electroluminescent device and an organic electroluminescent apparatus, and relates to the technical field of organic electroluminescent materials.The compound of formula I is used as a mother nucleus, and is connected with an arylamine group;one of side chains of the arylamine group contains a 1,1,4,4-tetramethyl-1,2,3,4-tetrahydronaphthalene derivative;and the other side chain of the arylamine group is one of an aryl group or a heteroaryl group.The compound of formula I has a low refractive index, is applied to a thicker layer in a double-layer light-emitting auxiliary material, and makes the organic electroluminescent device prepared by matching the light emitted from the device with the low-refractive-film layer of formula I and the high-refractive light-emitting auxiliary material better play a light collecting role;the light emitted from the device can emit specific wavelength light, the emission spectrum can be narrowed, the light-emitting intensity of the specific wavelength light can be enhanced, light loss can be reduced, the light-emitting efficiency of the device can be improved, meanwhile, the device has a relatively low driving voltage and a relatively long service life.

The present invention discloses a 2-amino-5-hydroxytetralin derivative containing a hydroxypyridone side chain, as well as its preparation and application. The target compound is obtained by using 2-amino-5-hydroxytetralin as the parent nucleus, and performing one-step condensation of a specific linker with a benzyl-protected hydroxypyridone and subsequent deprotection. Experiments have shown that at the cellular level, it has a significant anti-ferroptosis effect on RSL-3 or Erastin-induced related tumor cells (human fibrosarcoma cells HT-1080), and has a good protective effect on MPP+-induced damage-related nerve cells (human neuroblastoma cells SH-SY5Y). It also has a strong agonist effect on dopamine D2 receptors (HEK 293 cells stably transfected with human dopamine D2 receptors), and can be used to prepare corresponding anti-Parkinson's drugs. The structural formula I or II of the 2-amino-5-hydroxytetralin derivative containing a hydroxypyridone side chain is as follows: #imgabs0#

To provide a new crystal of KUS121 useful as a medicine and a method for producing the same.SOLUTION: Provided is a crystalline form of 4-amino-3 - [6 - (4-fluoro-2-methylphenyl) pyridin-3-ylazo] naphthalene-1-sulfonic acid sodium salt dihydrate, characterized by a powder X-ray diffraction pattern having four or more diffraction angles (2 θ ± 0.5) selected from 6.9 °, 13.3 °, 14.2 °, 15.0 °, 17.1 °, 18.5 °, 19.6 °, 21.1 °, 22.9 °, 23.7 °, 26.7 °, 27.4 °, 29.5 °, 34.1 °, and 36.1 ° in an X-ray powder diffraction.SELECTED DRAWING: None