39 results about "Naphthalene Derivative" patented technology

To provide an atropisomer of a 1,1'-binaphthyl derivative that exhibits a high HTP value even in small quantities.SOLUTION: The present invention provides an atropisomer represented by, for example, a following structural formula (2.1), a polymerizable liquid crystal composition comprising the atropisomer and a polymerizable liquid crystal compound, an optical film, an image display device and an eyewear.SELECTED DRAWING: None

The invention belongs to the field of chemical detection, and relates to a fluorescent probe based on naphthalene derivatives, a preparation method of the fluorescent probe and application of the fluorescent probe in pH detection. The selected fluorophore naphthalene derivative has the advantages that the raw materials are simple and easy to obtain, the emission wavelength is in a visible light region, and the Stocks displacement is large (137 nm), so that the fluorescent probe pHP1 has the advantages of low background interference, small light damage to biological samples, strong sample penetrability, good light stability, high detection sensitivity and the like.

The invention discloses a kind of organic electroluminescent material and organic electroluminescent device and application, the organic electroluminescent material can be used as the functional layer of organic electroluminescent device, with 9 alkyl 9 phenyl 9H fluorene as parent nucleus, directly connected to arylamine on parent nucleus, one of the side chains of arylamine is aryl or heteroaryl, and the other side chain is 1,1,4,4 tetramethyl 1,2,3,4 tetralin derivative, compared to other compounds, the organic electroluminescent material compound of the present invention has small lateral leakage, can reduce adjacent pixels in device and produce lateral leakage current, cause adjacent pixels to be lit, produce lateral crosstalk between adjacent sub-pixels, affect the phenomenon of color display. The organic electroluminescent material of the present invention is as the functional layer of organic electroluminescent device, can solve the problems such as color display and picture display abnormality affected by OLED display device lateral leakage.

The invention belongs to the technical field of biological medicines, and relates to phenyl naphthalene derivatives and application thereof in preparation of medicines for preventing and treating tumors or medicines for neuroprotection. The compound is a compound shown in a formula I or a formula II or a pharmaceutically acceptable salt thereof. In the formula I, A is not present or is carbonyl, A'is carbonyl, sulfuryl, oximido and imino, R1 is amino, nitryl, acylamino, sulfonamide, aryl methoxy, aryl ethyoxyl, fluorine atom, trifluoromethyl, ureido, amidoxime, amidino and N-methyl sulfonamide, and R2 is hydrogen atom, methoxy, amino, nitryl, acylamino, amidoxime, amidino or fluorine atom; r2 and H2N-A'are located at the adjacent position of a benzene ring, R2 or H2N-A 'is located at the para-position of phenyl, and X1 and X2 are independently selected from CH or N. The phenyl naphthalene derivative provided by the invention has relatively high NQO2 inhibitory activity, and can be used as a chemical drug for tumor treatment and a neuroprotective agent for neurological diseases.

The present invention relates to a pharmaceutically acceptable salt and a crystal form of a tetrahydronaphthalene derivative, and a preparation method. Specifically, the present disclosure provides a pharmaceutically acceptable salt and a crystal form of (S)-3-(5-(4-((1-(4-((1R,2R)-6-hydroxy-2-isobutyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenyl)piperidin-4-yl)methyl)piperazin-1-yl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione, and a preparation method therefor. The corresponding salt has good stability and can be better used for clinical treatment.

The invention discloses a chiral binaphthol-based fluorescent material as well as a preparation method and application thereof, and belongs to the technical field of organic photoelectric materials. The fluorescent material takes a chiral binaphthyl derivative as a skeleton, and a chiral binaphthyl group is introduced into a para-position position of tetrafluoroterephthalonitrile, so that a chiral space charge transfer luminescence system with a clear structure is formed. The preparation method comprises two steps of nucleophilic substitution reaction, the reaction condition is mild, the synthetic route is simple, and the yield is stable. The material has dual-state emission and aggregation enhanced luminescence characteristics, avoids aggregation quenching, has excellent circular polarization luminescence performance, has a luminescence asymmetry factor (Glum) of 3.6 * 10 <-3 >-5.9 * 10 <-3 >, and can still maintain stable chiral luminescence characteristics in a doped film. The material can be widely applied to the fields of commercial anti-counterfeiting, fluorescent ink, circular polarization luminescent devices, 3D display, information encryption, biological probes, LED light sources and the like, and has good industrial amplification potential and practical application value.

The invention belongs to the technical field of perovskite cells, and particularly discloses high-orientation perovskite, a preparation method and a solar cell prepared from the high-orientation perovskite, and the high-orientation perovskite comprises a mixture of naphthalene derivatives of sulfonic acid groups and amido, a perovskite component and a precursor solution, the mixture of naphthalene derivatives of sulfonic groups and amido is a mixture of potassium 6-hydroxy-2-naphthalene sulfonate and 6-bromo-2-naphthylamine hydrochloride, the molar mixing ratio of the potassium 6-hydroxy-2-naphthalene sulfonate to the 6-bromo-2-naphthylamine hydrochloride is 1: 0-1: 1, the perovskite component mainly comprises ABX3, and A is at least one of Cs, FA and MA; b is at least one of Pb and Sn; and X is I. According to the invention, crystal lattices are anchored through coordination of sulfonate radicals / hydroxyl radicals and Pbas, occupation of ammonium radicals on FAvacancies and the like, aromatic interaction among naphthalene rings in molecules is utilized to synergistically guide perovskite to orderly grow out of a (100) plane, inhibit lattice inclination and defect formation and regulate and control the orientation of perovskite crystals, so that the perovskite film with high orientation is obtained, and the perovskite film has good application prospects. And the photovoltaic performance of the perovskite solar cell is improved.

The present invention discloses a preparation method of substituted naphthalene derivatives. The method comprises the following steps: in the presence of methyl trifluoromethanesulfonate and potassium bromide, in a solvent, reacting a compound shown by formula II with a compound shown by formula III to obtain a substituted naphthalene derivative shown by formula I. The present invention relates to a preparation method for efficiently preparing substituted naphthalene derivatives by the synergistic catalysis of an organic reagent methyl trifluoromethanesulfonate (MeOTf) and potassium bromide (KBr). The whole process does not involve metals, the substrates are convenient to obtain, the reaction conditions are mild, and the operation is simple.

The invention provides a naphthyl photoacid generator and a synthesis method thereof. The photoacid generator comprises the following structural general formula: # imgabs0 #, and in the structural general formula, R is C1-C12 alkane. The preparation method of the photoacid generator comprises the following steps: (1) carrying out nucleophilic reaction on a halogenated methylnaphthalene derivative and a sodium mercaptide derivative at different positions to prepare a methylnaphthalenesulfane derivative; and (2) preparing a sulfonium salt compound through a reaction of the methylnaphthalenesulfane derivative and the halogenated methylnaphthalene derivative, and further preparing the naphthyl photoacid generator through an ion exchange method. The prepared photoacid generator is a novel photoacid generator and has good fat solubility, and the yield and purity of the preparation method are high.

The invention belongs to the technical field of organic synthesis, and provides a multifunctional naphthalene derivative as well as a preparation method and application thereof. In the structural formula of the multifunctional naphthalene derivative, R2 is alkyl, phenyl, 2-naphthyl, 1-naphthyl, 2-thienyl, an aromatic ring connected with an electron withdrawing group or an aromatic ring connected with an electron donating group, and the electron withdrawing group and the electron donating group comprise methyl, methoxyl, trifluoromethyl or halogen; r3 is H, methyl or methoxyl; r4 is H, methyl, phenyl or alkynyl. According to the preparation method, a 1, 6-diyne-3-alcohol compound is taken as a raw material, [2-(di-tert-butylphosphine) biphenyl] gold chloride (I) and silver tetrafluoroborate are taken as catalysts, intramolecular 6-endo-dig cyclization, 3, 3-Claisen rearrangement and aromatization reaction are performed, and finally, deacylation reaction is performed to obtain the multifunctional naphthalene derivative with phenyl, phenylethynyl and naphthalene ring structures. The method has application value in multiple fields.

The invention provides a method for photocatalytic asymmetric intermolecular dearomatization cycloaddition reaction based on naphthalene derivatives, and belongs to the technical field of chemical synthesis. The olefin compound and the 2-pyrazole amide naphthalene derivative are used as reaction raw materials, [2 + 2]-cycloaddition or [4 + 2]-cycloaddition reaction is realized under specific reaction conditions, and the obtained product has high yield and high enantioselectivity. The substrate provided by the invention is good in universality, is especially suitable for raw materials containing naphthalene, overcomes the problem that naphthalene-containing compounds are not easy to react in the prior art, and has a good application prospect.

The present invention relates to dihydronaphthalene derivatives of formula D specified in claim 1; to a liquid crystalline medium comprising a compound of formula D; and to high-frequency components containing these media, in particular microwave components for high-frequency devices such as devices for phase shifting microwaves, tunable filters, tunable metamaterial structures, and electron beam controlled antennas such as phased array antennas.

To provide an aromatic compound having longer relaxation time of 13C nucleus excited by a DNP apparatus than conventional ones.SOLUTION: An aromatic compound is composed of a stable isotope. Two adjacent carbon atoms are 13C, a spin quantum number of an atomic nucleus of other atom to which the two adjacent carbon atoms are coupled is zero, and a hydrogen atom having a spin coupling constant coupled through a carbon atom to 13C nucleus is substituted by a deuterium atom.SELECTED DRAWING: None

The present invention provides methods for treating and / or preventing breast cancer, including locally advanced or metastatic ER+ and HER2- breast cancers in patients requiring treatment, compounds for use in treatment, and combinations thereof. [Solution] Administer a compound of formula (I), or a pharmaceutically acceptable salt, enantiomer, stereoisomer, solvate, polymorph, isotope derivative thereof, or a prodrug thereof. JPEG2026136114000154.jpg65134

The invention discloses synthesis of a tetrahydronaphthalene derivative and an intermediate thereof. The invention provides a synthesis method of a compound I. The synthesis method comprises the following step: in a solvent, in the presence of acid and a palladium catalyst, and in the presence of a reducing agent, carrying out hydroxyl reduction reaction on a compound IV to prepare the compound I. The preparation method has one or more of the following advantages: (1) good reaction selectivity, (2) mild and easy-to-control reaction, (3) high reaction yield, (4) good product purity, and (5) easily available materials, simple and convenient reaction operation, and good application prospect and value.

Described herein are compounds of Formula I and their pharmaceutically acceptable salts, solvates, or stereoisomers, as well as their uses (e.g., as estrogen receptor degraders).

The invention discloses a multi-stimulus response light-emitting system constructed by a naphthalene derivative G1 and cucurbit [n] uril and application of the multi-stimulus response light-emitting system, and relates to the technical field of multi-stimulus response light-emitting materials. According to the multi-stimulus response light-emitting system, the naphthalene derivative G1 is taken as a core, the naphthalene derivative G1 is driven to dynamically change in a molecular accumulation mode through two stimuli of concentration internal regulation and control and cucurbituril external regulation and control, then continuous light-emitting color change from blue to yellow is generated, and the change has regularity, controllability and reversibility. The multi-stimulus response light-emitting system can convert various stimuli into diversified optical signals, and a material basis is provided for applications such as multi-level information encryption and anti-counterfeiting.

A 1, 2-dihydronaphthalene derivative copolymer synthesized based on active anion polymerization and a preparation method thereof belong to the technical field of high polymer materials, are synthesized based on an active anion polymerization mechanism, and are formed by copolymerization of a 1, 2-dihydronaphthalene derivative, a styrene derivative and a diene monomer. The 1, 2-dihydronaphthalene derivative is 1, 2-dihydronaphthalene and functionalized 1, 2-dihydronaphthalene with a substituent group on an aromatic ring or an aliphatic ring; the styrene derivative is styrene, alpha-methyl styrene, 1, 1-diphenylethylene and a chain segment formed by mutual polymerization of the monomers; the dialkene monomer is butadiene, isoprene, 2, 3-dimethyl-1, 3-butadiene and a chain segment formed by mutual polymerization of the dialkene monomer, the isoprene and the 2, 3-dimethyl-1, 3-butadiene. According to the invention, binary and ternary copolymerization of various monomers with similar structures but different performances is realized; the polymerization condition is mild, the copolymer with controllable molecular weight and distribution is easy to obtain, and the performance and application range of synthetic resin and synthetic rubber are further expanded.

The application discloses an organic electroluminescent material, an organic electroluminescent device and an organic electroluminescent apparatus, and relates to the technical field of organic electroluminescent materials.The compound of formula I is used as a mother nucleus, and is connected with an arylamine group;one of side chains of the arylamine group contains a 1,1,4,4-tetramethyl-1,2,3,4-tetrahydronaphthalene derivative;and the other side chain of the arylamine group is one of an aryl group or a heteroaryl group.The compound of formula I has a low refractive index, is applied to a thicker layer in a double-layer light-emitting auxiliary material, and makes the organic electroluminescent device prepared by matching the light emitted from the device with the low-refractive-film layer of formula I and the high-refractive light-emitting auxiliary material better play a light collecting role;the light emitted from the device can emit specific wavelength light, the emission spectrum can be narrowed, the light-emitting intensity of the specific wavelength light can be enhanced, light loss can be reduced, the light-emitting efficiency of the device can be improved, meanwhile, the device has a relatively low driving voltage and a relatively long service life.

The present invention discloses a 2-amino-5-hydroxytetralin derivative containing a hydroxypyridone side chain, as well as its preparation and application. The target compound is obtained by using 2-amino-5-hydroxytetralin as the parent nucleus, and performing one-step condensation of a specific linker with a benzyl-protected hydroxypyridone and subsequent deprotection. Experiments have shown that at the cellular level, it has a significant anti-ferroptosis effect on RSL-3 or Erastin-induced related tumor cells (human fibrosarcoma cells HT-1080), and has a good protective effect on MPP+-induced damage-related nerve cells (human neuroblastoma cells SH-SY5Y). It also has a strong agonist effect on dopamine D2 receptors (HEK 293 cells stably transfected with human dopamine D2 receptors), and can be used to prepare corresponding anti-Parkinson's drugs. The structural formula I or II of the 2-amino-5-hydroxytetralin derivative containing a hydroxypyridone side chain is as follows: #imgabs0#

To provide a new crystal of KUS121 useful as a medicine and a method for producing the same.SOLUTION: Provided is a crystalline form of 4-amino-3 - [6 - (4-fluoro-2-methylphenyl) pyridin-3-ylazo] naphthalene-1-sulfonic acid sodium salt dihydrate, characterized by a powder X-ray diffraction pattern having four or more diffraction angles (2 θ ± 0.5) selected from 6.9 °, 13.3 °, 14.2 °, 15.0 °, 17.1 °, 18.5 °, 19.6 °, 21.1 °, 22.9 °, 23.7 °, 26.7 °, 27.4 °, 29.5 °, 34.1 °, and 36.1 ° in an X-ray powder diffraction.SELECTED DRAWING: None

Provided are a binaphthyl derivative that is capable of forming a liquid crystal composition having a large reflection wavelength change range accompanying voltage application, and a liquid crystal composition. The binaphthyl derivative has a binaphthyl skeleton, a redox functional group that links to the binaphthyl skeleton so as to allow pi-electron conjugation, and a mesogenic group. The liquid crystal composition contains a binaphthyl derivative, a liquid crystalline compound, and an electrolyte.

This invention provides a D-π-A type triarylborane naphthalene derivative with dual-state emission characteristics, its preparation method, and its application, belonging to the field of carbocyclic compound technology. The general structural formula of the naphthalene derivative is shown in Formula I, where Ar is phenyl or p-methoxyphenyl. The preparation method of the naphthalene derivative involves lithiation of a bromoaryl amine precursor with n-butyllithium under an inert atmosphere, followed by quenching with dimethylboron fluorine to obtain the corresponding naphthalene derivative. The bromoaryl amine precursor is 2-bromo-6-( N , N '-Diphenylamino)naphthalene or 2-bromo-6-[ N , N '-Di(4-methoxyphenyl)amino]naphthalene. The compounds of this invention maintain high fluorescence quantum yields in a variety of solvents and exhibit strong luminescence in solid-state applications (powders and films), making them high-performance DSE materials.

The application discloses a 2-phenyl naphthalene derivative and application thereof in preparation of an anti-hepatoma drug. The application provides some 2-phenyl naphthalene derivatives as human ribonucleotide reductase inhibitors, and the structure is shown as formula (I). Experiments prove that the 2-phenyl naphthalene derivative has obvious human ribonucleotide reductase inhibiting activity and effective anti-hepatoma effect, and provides a new selection for development and application of the anti-hepatoma drug based on inhibiting human ribonucleotide reductase activity.

The invention belongs to the technical field of organic pollutant treatment, and particularly relates to a biochar molecularly imprinted polymer as well as a preparation method and application thereof. Filtering and freezing the alkali-modified biomass solution, and then pyrolyzing the alkali-modified biomass solution in an oxygen-containing protective atmosphere to obtain modified biochar; the modified biochar is used as a carrier, methacrylic acid is used as a monomer, naphthalene or a naphthalene derivative is used as a template molecule, in-situ polymerization is carried out in an oxygen-free environment under the action of a cross-linking agent and an initiator, a molecularly imprinted polymer is anchored on the carrier, and the biochar molecularly imprinted polymer is prepared. Through a strategy of'alkali modification + freezing + aerobic pyrolysis', a modification mechanism of water vapor-alkali synergy and oxygen-alkali synergy is formed, the specific surface area and the pore structure of the biochar are remarkably improved, abundant anchoring points are provided for a molecularly imprinted polymer, polymer agglomeration is avoided, more imprinted cavities are exposed, and the biochar has good biocompatibility. The template molecule can be quickly diffused to a specific binding site, so that the adsorption performance on polycyclic aromatic hydrocarbon is remarkably improved.

The present invention relates to a pharmaceutically acceptable salt and a crystal form of a tetrahydronaphthalene derivative, and a preparation method. Specifically, the present disclosure provides a pharmaceutically acceptable salt and a crystal form of (S)-3-(5-(4-((1-(4-((1R,2R)-6-hydroxy-2-isobutyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenyl)piperidin-4-yl)methyl)piperazin-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione, and a preparation method therefor. The corresponding salt has good stability and can be better used for clinical treatment.

The invention discloses a method for synthesizing an axially chiral isoquinoline naphthalene compound based on nickel / light concerted catalysis, and belongs to the field of organic chemical synthesis. According to the present invention, the racemic isoquinoline naphthalene derivative is subjected to kinetic resolution, such that the target axial chiral isoquinoline naphthalene compound is synthesized with high yield and high enantioselectivity; according to the method, an isoquinoline naphthalene derivative and carboxylic acid are taken as raw materials and react under the action of a nickel catalyst, a chiral oxazoline ligand, a photosensitizer and alkali through visible light irradiation, so that efficient synthesis of a target product and efficient recovery of the raw materials are realized. Further, the axially chiral compound can be converted into a corresponding N-oxide catalyst through an oxidation reaction. The catalyst shows excellent catalytic activity and stereoselectivity in an asymmetric allylation reaction. The method has the advantages of mild reaction conditions, simplicity and convenience in operation, wide substrate applicability, high enantioselectivity, good atom economy and the like, and has an important industrial application prospect.

The invention discloses a method for preparing a diaryl acetylene and phenylethynyl pyridine cross-halo addition product, which comprises the following steps: adopting a mixed solvent of dichloromethane and trifluoroacetic acid, and under the irradiation of a high-pressure mercury lamp, carrying out light dehydrogenation Diels-Alder reaction on the diaryl acetylene and the phenylethynyl pyridine to obtain two mono 4-pyridyl-diaryl substituted naphthalene derivatives. The reaction system inhibits the halo addition reaction of phenylethynyl pyridine, improves the yield of the cross halo addition reaction, and provides a practical synthesis method for the synthesis of the mono-4-pyridyl-diaryl substituted naphthalene derivative.