Methods for measuring the distribution, metabolism and clearance of traceable small molecule compounds in the brain

A technology of small molecular compounds and measurement methods, applied in diagnostic recording/measurement, medical science, sensors, etc., can solve problems such as low resolution, inability to obtain tracer diffusion, inability to achieve accurate positioning and measurement, and achieve accurate calculations The effect of the method

Inactive Publication Date: 2011-12-28
PEKING UNIV THIRD HOSPITAL
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  • Claims
  • Application Information

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Problems solved by technology

Moreover, due to the low resolution of magnetic resonance spectroscopy (0.5×0.5×0.5cm 3 ), it is impossible to obtain the tracer in a specific bra

Method used

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  • Methods for measuring the distribution, metabolism and clearance of traceable small molecule compounds in the brain
  • Methods for measuring the distribution, metabolism and clearance of traceable small molecule compounds in the brain
  • Methods for measuring the distribution, metabolism and clearance of traceable small molecule compounds in the brain

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Experimental program
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Embodiment Construction

[0031] figure 1 A measurement device for the distribution, metabolism and clearance of traceable small molecule compounds in the brain is shown, which includes an MRI device 20 , an introduction device 30 for introducing traceable small molecule compounds and a control device 40 . The introduction device 30 includes a microsyringe 32 and an introduction pump 34 .

[0032] Such as figure 1 As shown, the subject 10 (the human body in the figure) enters the MRI apparatus 20 along with the examination bed 12 , and the MRI apparatus 20 is used to capture dynamic images of the brain tissue of the subject 10 . The traceable small molecule compound can be driven by the introduction pump 34 and directly introduced into the brain of the subject 10 through the microinjection needle 32 .

[0033] Those skilled in the art can understand that traceable small molecule compounds should be selected from substances that do not react with the brain ISF of the subject and the tissue or cell sur...

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Abstract

The invention provides a method for measuring the distribution, metabolism and clearance of traceable small molecule compounds in the brain, the method comprising: placing the brain of the subject under test in an imaging device; using the imaging device to form the basis of the brain of the subject under test Imaging; introduce the compound into the interstitial fluid of the brain of the subject; use the imaging device to form a dynamic image of the brain of the subject; perform temporal and spatial preprocessing on the dynamic image and the basic image to obtain the net concentration image of the compound in the brain; Model estimation and analysis are performed on the net concentration images to obtain information on the distribution, metabolism and clearance process of compounds in the brain after they diffuse in the interstitial fluid of the brain. The present invention introduces a traceable small molecule compound of a corresponding size, dynamically displays and quantitatively measures the process of distribution, metabolism and clearance of the molecule and small molecules with similar molecular weight and properties in the brain through the brain tissue fluid in the living body.

Description

technical field [0001] The invention relates to a method for measuring the distribution, metabolism and clearance of a traceable small molecule compound in the brain, in particular, it relates to a traceable small molecule compound which is introduced into the brain of the subject through the interstitial fluid of the brain, and then observed Methods for measuring the distribution, metabolism and clearance of introduced traceable small molecule compounds in the interstitial fluid of the brain. Background technique [0002] Brain interstitial fluid ("interstitial fluid", interstitial fluid, hereinafter referred to as ISF) is a fluid existing in the extracellular space of the brain ("extracellular space", hereinafter referred to as ECS). Brain ISF and extracellular matrix together constitute the microenvironment for the survival of brain cells, which plays a key role in ensuring the stability of electrical signal transmission between brain cells, forming material transport cha...

Claims

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Application Information

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IPC IPC(8): A61B5/00A61B5/055
Inventor 韩鸿宾
Owner PEKING UNIV THIRD HOSPITAL
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