Pharmaceutical composition containing arctigenin and its application

A technology of arctigenin and composition is applied in the field of pharmaceutical composition containing arctigenin and its use, and can solve problems such as limited curative effect and the like

Active Publication Date: 2012-02-01
SHANDONG NEWTIME PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinical data show that the efficacy of single use of ATRA is relatively limited

Method used

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  • Pharmaceutical composition containing arctigenin and its application
  • Pharmaceutical composition containing arctigenin and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1 Microemulsion

[0039] Arctium aglycone 0.1g

[0040] All-trans retinoic acid 5g

[0041] Peppermint Oil 35g

[0042] Polyoxyethylene-23-Lauryl Ether 60g

[0043] 1,2-Propanediol 30g

[0044] Preparation process: Weigh the recipe quantities of peppermint oil, polyoxyethylene-23-lauryl ether, 1,2-propanediol, mix and stir evenly, then add arctigenin and all-trans retinoic acid to dissolve, or ultrasonically treat to accelerate Dissolve to obtain a clear concentrated solution, namely arctigenin and all-trans retinoic acid microemulsion concentrate. The particle size was measured by a laser particle size analyzer, and the average particle size was 15 nm.

Embodiment 2

[0045] Example 2 Microemulsion

[0046] Arctium aglycone 2g

[0047] All-trans retinoic acid 2g

[0048] Spearmint Oil 30g

[0049] Decaglycerol Monostearate 55g

[0050] 1,2-Propanediol 25g

[0051] Preparation process: Weigh the recipe quantities of spearmint oil, decaglycerol monostearate, 1,2-propanediol, mix them and stir evenly, then add arctigenin and all-trans retinoic acid to dissolve, or ultrasonically treat to accelerate dissolution , a clear concentrated solution is obtained, namely arctigenin and all-trans retinoic acid microemulsion concentrate. The particle size was measured by a laser particle size analyzer, and the average particle size was 15 nm.

Embodiment 3

[0052] Example 3 Microemulsion

[0053] Arctium Aglycone 10g

[0054] All-trans retinoic acid 0.5g

[0055] Peppermint Oil 40g

[0056] Caprylic acid ethyl oleate 55g

[0057] 1,2-Propanediol 45g

[0058] Macrogol 8000 55g

[0059] Preparation process: Weigh the recipe quantities of peppermint oil, ethyl caprylic acid oleate, 1,2-propanediol, and polyethylene glycol 8000, mix and stir evenly, then add arctigenin to dissolve, or ultrasonically treat to accelerate the dissolution, and obtain a clear Concentrate, namely arctigenin and all-trans retinoic acid microemulsion concentrate. The particle size was measured by a laser particle size analyzer, and the average particle size was 40 nm.

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Abstract

The invention relates to a pharmaceutical composition containing arctigenin and an application of the pharmaceutical composition in preparing medicine for treating cancer, especially an application of the pharmaceutical composition in preparing medicine for treating leukemia. The pharmaceutical composition of the invention comprises the active components arctigenin and all-trans retinoic acid. Preferably, according to an amount of substance, in the pharmaceutical composition of the invention, the mol ratio of arctigenin to all-trans retinoic acid is 1:0.01-100. In the pharmaceutical composition, the combination of the active components arctigenin and all-trans retinoic acid has synergetic effect for anti-leukemia.

Description

technical field [0001] The present invention relates to a medicinal composition containing arctigenin and its use in preparing a medicine for treating cancer, especially its use in preparing a medicine for treating leukemia. Background technique [0002] Currently, cancer is one of the major diseases that seriously affects human health and threatens human life. Cancer, together with cardiovascular and cerebrovascular diseases and accidents, constitute the top three causes of death in all countries in the world today. Therefore, the World Health Organization and national government health departments have made the fight against cancer a top priority. There are three main ways to treat cancer in the world. One is surgical resection to remove diseased tissue to prevent the spread of cancer cells; the second is to use chemotherapy or radiotherapy to kill cancer cells; the third is to use drugs. The method of surgical resection increases the pain of the patient, hurts its vital...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61K9/107A61K9/00A61K9/20A61K9/48A61K9/16A61P35/00A61P35/02A61K31/203
Inventor 赵志全刘松燕
Owner SHANDONG NEWTIME PHARMA
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