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Use of icarlin in preparation of drug for preventing and treating chronic obstructive pulmonary diseases

A technology for chronic obstructive pulmonary disease, icariin, applied in the field of biomedicine

Inactive Publication Date: 2012-02-01
AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] So far, there have been no relevant research reports on the application of icariin in the prevention and treatment of chronic obstructive pulmonary disease at home and abroad.

Method used

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  • Use of icarlin in preparation of drug for preventing and treating chronic obstructive pulmonary diseases
  • Use of icarlin in preparation of drug for preventing and treating chronic obstructive pulmonary diseases
  • Use of icarlin in preparation of drug for preventing and treating chronic obstructive pulmonary diseases

Examples

Experimental program
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Effect test

Embodiment 1

[0017] 1. Experimental animals

[0018] Thirty-six healthy and clean male Sprague-Dauley (SD) rats (provided by Experimental Animal Technology Company of Chengdu Dashuo Biotechnology Co., Ltd.), aged 21 ± 1 month, weighing 500-600 g.

[0019] 2. Grouping and Modeling

[0020] SD rats were randomly divided into 6 groups: Group A, Group B, Group C, Group D, Group E, and Group F, with 6 rats in each group.

[0021] Group A: normal group. Rats were placed in a fumigation apparatus in which fresh air exposure was substituted for cigarette smoke exposure. From the 8th day of modeling, 1ml of sterilized normal saline was administered orally, once a day, 5 days a week, for 3 consecutive weeks.

[0022] Group B: COPD model group. Referring to the method provided in the literature [42-53], the rats were smoked in a closed wooden box. The cigarettes were Peony brand flue-cured cigarettes with filters (provided by Shanghai Tobacco Company), and each cigarette contained 1.0mg of nicoti...

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Abstract

The invention belongs to the field of biomedicine, relates to a novel medicinal use of icarlin as an active component of a traditional Chinese medicine, and specifically, relates to a use of icarlin in preparation of a drug for preventing and treating chronic obstructive pulmonary diseases. A result of an animal model experiment shows that icarlin can activate a hypothalamic-pituitary-adrenal (HPA) axis, stimulate endogenous hormone secretion, inhibit activation of NF-kB, protect pulmonary functions of an animal model having chronic obstructive pulmonary diseases caused by cigarette smoke exposure, inhibit infiltration of inflammatory cells and expression of proinflammatory cytokines in vivo, and promote expression of cytokines with functions of inflammation suppression. Icarlin can be utilized as an active component, and can be combined with pharmaceutically acceptable carriers to be prepared into a drug composition for preventing and treating chronic obstructive pulmonary diseases.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to a new medicinal application of icariin, an active ingredient of traditional Chinese medicine, in particular to the application of icariin in the preparation of medicines for preventing and treating chronic obstructive pulmonary disease. Background technique [0002] Chronic Obstructive Pulmonary Disease (COPD) is a progressive disease of airflow limitation that is not fully reversible and is associated with an inflammatory response in the lungs. COPD mainly involves the lungs, but it can also cause systemic (or extrapulmonary) adverse effects. The main clinical manifestations are chronic cough, sputum production, shortness of breath or dyspnea, wheezing and chest tightness. As the disease progresses, systemic inflammatory reactions will also occur, seriously affecting the patient's working ability and quality of life. COPD has a large number of patients, a high mortality rate, and a hea...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P11/00
Inventor 董竞成曾丽绚吴金峰刘宝君曹玉雪张红英
Owner AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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