Enclosed laser shock wave transdermal administration device

Abstract

The invention discloses an enclosed laser shock wave transdermal administration device, which consists of a pulse laser, a laser protecting cover, a focusing lens, a restraining layer, an absorbing layer, a protecting layer and a liquid medicine box, wherein one end of the laser protecting cover is connected to the laser head of the pulse laser, and the other end of the laser protecting cover is connected with the liquid medicine box, so that acting laser pulses and scattered light of the laser pulses are completely restrained in the laser protecting cover, and the operation security is improved; the protecting layer, the absorbing layer and the restraining layer are formed in sequence on the liquid medicine box; and the smallest sum of the thicknesses of the absorbing layer and the protecting layer can be up to 20 mum, so that the transmission path of laser shock wave is remarkably shortened, the coupling efficiency of shock wave is increased, and the laser energy needed in the transdermal administration process is reduced. The administration device has a compact structure, low cost and short medicament permeating time, is convenient and safe for using, and is suitable for clinical application.

Description

technical field [0001] The invention relates to a human body transdermal drug delivery device, in particular to a closed laser shock wave transdermal drug delivery device. Background technique [0002] Transdermal drug delivery is a kind of drug delivery method that penetrates the skin into the local tissue or circulatory system through a special device to achieve disease prevention or treatment. Compared with oral or injection administration, it does not require substantial incision of the skin (such as a surgical scalpel) or penetration of the skin (such as subcutaneous injection or needle sticking) for administration, and the process does not cause pain and is easy to treat. accepted by patients. In addition, this method will not be affected by factors such as food, pH value, digestive enzymes and running time in the digestive system, which can reduce the first-pass effect of the liver. Due to the above-mentioned characteristics, transdermal drug delivery technology has...

AI Technical Summary

Problems solved by technology

But the deficiency of this method is: (1) the laser beam of this design is directly exposed to the outside (referred to as " open "), when the doctor implements transdermal administration to the patient, in order to protect the eyes, all need to wear protective goggles, so When it is applied, the requirements for laser safety protection are high, and the safety of operation and use is low; (2) the absorbing layer of this method is a 1mm thick black polystyrene sheet. After passing through the polystyrene target with a thickness of 1mm, the intensity of the laser shock wave is greatly weakened, which makes the transmission efficiency of the laser shock wave low, so it needs to use higher single-pulse laser energy; (3) the polystyrene absorbing layer of this method is in the Under the action of laser, debris will splash and pollute the medical environment; (4) The penetration of drugs into the skin is mainly realized by the concentration gradient difference between the liquid and the skin, the mode of action is single, and the drug penetration time is long. Only suitable for laboratory operations, it is difficult to apply to clinical medicine

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