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Pharmaceutical composition for improving oral bioavailability of morin

A technology of morin and its composition, applied in the field of medicine, can solve the problems of poor water solubility and fat solubility, affecting the efficacy of morin, and restricting its application

Active Publication Date: 2013-03-13
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The extensive and significant biological effects of morin make it of important research value, but its water solubility and fat solubility are poor, which makes the carrier materials of various preparation methods limited in its loading capacity, and the drug loading capacity of the obtained preparations is very low. It affects the efficacy of morin itself, and also limits its clinical application. At present, there is no corresponding dosage form on the market

Method used

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  • Pharmaceutical composition for improving oral bioavailability of morin
  • Pharmaceutical composition for improving oral bioavailability of morin
  • Pharmaceutical composition for improving oral bioavailability of morin

Examples

Experimental program
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Effect test

Embodiment 1

[0040] Take 1g of morin and 1.5g of soybean lecithin, add 50ml of absolute ethanol, stir and react at 40°C for 2h to obtain a clear solution. After removing ethanol under reduced pressure at 50°C, collect the solid and vacuum-dry it for 12 hours, and then pulverize it to obtain the morin phospholipid complex.

Embodiment 2

[0042]Take 1 g of morin and 5 g of soybean lecithin, add 40 ml of tetrahydrofuran, stir and react at room temperature for 1.5 h to obtain a clear solution. After removing tetrahydrofuran under reduced pressure at 40°C, the collected solid was vacuum-dried for 12 hours, and crushed to obtain the morin-phospholipid complex.

Embodiment 3

[0044] Take 1g of morin and 9g of egg yolk lecithin, add 40ml of methanol, stir and react at room temperature for 3h to obtain a clear solution. After the methanol was removed under reduced pressure at 40°C, the collected solid was vacuum-dried for 12 hours and pulverized to obtain the morin-phospholipid complex.

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Abstract

The invention provides a method of applying a surfactant capable of inhibiting the activity of P-glycoprotein in preparation of a medicine used for improving oral bioavailability of morin. The medicine provided in the invention is a pharmaceutical composition prepared from morin and a specific surfactant, wherein, the surfactant capable of inhibiting the activity of P-glycoprotein is used as a stabilizing agent of morin suspension, or the surfactant and morin form a compound through a weak interaction force. According to the invention, application of the surfactant capable of inhibiting the activity of P-glycoprotein enables absorption of morin in the pharmaceutical composition to be increased and oral bioavailability of morin to be substantially improved.

Description

technical field [0001] The invention relates to a pharmaceutical composition capable of improving the oral bioavailability of morin and the application of a surfactant as a P-glycoprotein inhibitor in preparing a drug for improving the oral bioavailability of morin, which belongs to the technical field of medicine. Background technique [0002] Morin is one of the flavonoids. It is a light yellow pigment extracted from the bark of Moraceae plants such as yellow mulberry and Morus orange tree and many Chinese herbal medicines. Its chemical name is 3,5,7,2′, 4'-pentahydroxyflavone (3,5,7,2',4'-pentahydroxyflavone), its chemical structure is as follows: [0003] [0004] Studies have shown that morin has a wide range of pharmacological effects such as anti-cancer, anti-inflammation, and anti-oxidation. It can be used clinically for anti-viral infection, headache, coronary heart disease, chronic inflammation, and cancer treatment. It can be used in combination with other chem...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61K47/24A61K47/34A61P35/00A61P29/00A61P39/06A61P31/12A61P25/00A61P9/10A61P19/06
Inventor 张志荣龚涛张金洁孙逊
Owner SICHUAN UNIV
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