Glabrous sarcandra herb injection and preparation method thereof

A technique for Zongjiefeng and injection, which is applied in the field of Zongjiefeng injection and its preparation, can solve problems such as structural instability, and achieve the effects of system stability, high content and good curative effect.

Inactive Publication Date: 2012-05-23
JIANGXI HERBI SKY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to literature reports, both rosmarinic acid and chlorogenic acid have strong physiological activities, but their structures are unstable

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Take 5000g of sarcocarpus, add 10 times the amount of water to decoct twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.33 (70°C), add ethanol to precipitate twice, and use it for the first time The alcohol content is 70%, and the alcohol content is 80% for the second time. Refrigerate for 48 hours each time, filter, recover ethanol from the filtrate and concentrate to contain 10g of crude drug per 1ml, adjust the pH value to 4 with hydrochloric acid solution, and heat to reflux for 1 hours, refrigerated for 24 hours, filtered, the filtrate was heated and refluxed for 1 hour, refrigerated for 24 hours, filtered, the filtrate was adjusted to pH 6.0 with sodium hydroxide solution, and heated until the content ratio of chlorogenic acid and cryptochlorogenic acid in the filtrate was 2:1, add an appropriate amount of activated carbon, filter, dilute the filtrate with water for injection to 1000ml, filter, add ...

Embodiment 2

[0015] Take 10000g of sargassum, add 10 times the amount of water and decoct three times, 2 hours each time, combine the decoction, filter, concentrate the filtrate to a relative density of 1.25 (70°C), add ethanol to precipitate twice, and make the containing The alcohol content is 70%, the second alcohol content is 80%, refrigerated for 72 hours each time, filtered, the filtrate recovers ethanol and concentrates to contain 15g of crude drug per 1ml, adjusts the pH value to 3 with hydrochloric acid solution, and heat-treats at 115°C for 0.5 hours, refrigerated for 48 hours, filtered, the filtrate was adjusted to pH 5.5 with sodium hydroxide solution, heated until the content ratio of chlorogenic acid and cryptochlorogenic acid in the filtrate was 3:1, an appropriate amount of activated carbon was added, filtered, and the filtrate was injected Dilute with water to 1000ml, filter, add 10ml of polysorbate 80, stir well, adjust the pH value to 6.0, filter, fill with nitrogen, pott...

Embodiment 3

[0017] Take 5000g of sargassum, add 8 times the amount of water, heat and reflux to extract three times, each time for 2 hours, combine the extracts, filter, concentrate the filtrate to a relative density of 1.4 (70°C), add ethanol to precipitate three times, and make the containing The alcohol content is 60%, the second alcohol content is 70%, the second alcohol content is 90%, each time refrigerated for 24 hours, filtered, the filtrate recovers ethanol and concentrates to contain 5g of crude drug per 1ml, and adjusts the pH value To 5, heat to reflux for 1 hour, refrigerate for 12 hours, filter, heat the filtrate to reflux for 1 hour, refrigerate for 24 hours, filter, heat the filtrate to reflux for 1 hour, refrigerate for 48 hours, filter, and adjust the pH value of the filtrate with sodium hydroxide solution to 6.5, heated until the content ratio of chlorogenic acid and cryptochlorogenic acid in the filtrate is 3:1, add an appropriate amount of activated carbon, filter, dil...

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PUM

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Abstract

The invention discloses a glabrous sarcandra herb injection and a preparation method thereof. The injection is a sterilized aqueous solution prepared by extracting glabrous sarcandra herb and is characterized in that every milliliter of the solution contains not less than 100 mu g of rosmarinic acid; every milliliter of the solution contains not less than 500 mu g of chlorogenic acid and cryptochlorogenic acid, wherein the ratio of the chlorogenic acid to the cryptochlorogenic acid is (2:1)-(5:4); and the pH value of the solution is 5.0-5.5. The injection is stable in quality.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a sarcophagus injection and a preparation method thereof. Background technique [0002] Zhongjiefeng Injection is recorded in the fourteenth volume of the Ministry of Health's Drug Standards for Traditional Chinese Medicine Prescriptions. This product has the functions of clearing away heat and detoxification, reducing swelling and dissipating stagnation, and can be used to treat pneumonia, appendicitis, cellulitis, bacillary dysentery, and abscess caused by excessive heat and toxin. It can also be used to treat digestive tract cancer, pancreatic cancer, etc. Cancer, liver cancer and other tumors. The product has a strong anti-inflammatory effect, but its effect on treating tumors still needs to be improved. During the research process, the applicant found that the content of rosmarinic acid and chlorogenic acid in Zhongjiefeng injection was very high according to t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K9/08A61P1/00A61P11/00A61P17/00A61P31/04
Inventor 艾样开吴安明吴孔松段国华徐岚吴奔虎张林建
Owner JIANGXI HERBI SKY CO LTD
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