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Application of salvianolic acid L in preparation of medicines used for treating tumor

An anti-tumor drug, the technology of salvianolic acid, applied in the field of application of salvianolic acid L in the preparation of drugs for treating tumors, can solve problems such as no reports

Inactive Publication Date: 2012-05-30
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The anti-tumor activity of salvianolic acid L of the present invention, and its use alone or in combination with multiple tumor drugs for clinical tumor treatment have not been reported so far

Method used

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  • Application of salvianolic acid L in preparation of medicines used for treating tumor
  • Application of salvianolic acid L in preparation of medicines used for treating tumor
  • Application of salvianolic acid L in preparation of medicines used for treating tumor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] The preparation of embodiment 1 salvianolic acid L

[0067] Take Danshen decoction pieces, put them in an extractor, add 4 times the volume of medicinal materials in water (containing 0.45% sodium bicarbonate), decoct for 2 hours, filter; continue decocting medicinal residues with 3 times the volume of water for 1 hour, filter , combined filtrate, concentrated to the extract with relative density of 1.2 (80°C); adding 95% ethanol to the extract to sink to 70% (25°C), let it stand for more than 12 hours, recovered ethanol under reduced pressure, concentrated to relative density It is the extract of 1.37 (60°C).

[0068] The obtained extract was dissolved in water, passed through AB-8 macroporous adsorption resin, washed with water 12 times the volume of the column bed, and the washing solution was adjusted to pH 3.0 with hydrochloric acid. Pass the above-mentioned acidic washing solution through the AB-8 macroporous adsorption resin again, wash it with acid water with a...

Embodiment 2

[0070] The preparation of embodiment 2 salvianolic acid L freeze-dried powder injection, prescription:

[0071] Salvianolic acid L 100g

[0072] Mannitol 100g

[0073]

[0074] Water for injection 2000ml

[0075] Made 1000 pieces

[0076] Process:

[0077] Weigh salvianolic acid L and the excipient mannitol in the prescription, add 1500ml of water for injection, stir to dissolve, stir and decolorize with 0.5g of activated carbon for 20 minutes, decarbonize with a 0.45 micron microporous membrane, replenish water to 2000ml, sterilize, filter, and pack , freeze-drying, to obtain.

Embodiment 3

[0078] The preparation of embodiment 3 salvianolic acid L injection

[0079] prescription:

[0080] Salvianolic acid L 100g

[0081] Mannitol 100g

[0082] Add water for injection to 2500ml

[0083] Make 1000 pieces

[0084] Take salvianolic acid L, add an appropriate amount of 1000ml water for injection to dissolve, and stir well; take another mannitol, add 500ml water for injection to dissolve, add to the above solution, stir well, keep stirring with 0.5 g of activated carbon for 20 minutes, filter, and adjust the pH of the filtrate When the value is 4.5-5.0, add water for injection to 2500ml, sterilize and filter, and pack in aliquots to obtain.

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PUM

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Abstract

The invention relates to an application of salvianolic acid L in preparation of medicines used for treating tumor, salvianolic acid L belongs to a phenolic acid compound which is a novel water-soluble compound with a confirmed structure extracted from a traditional Chinese medicine red sage root, a pharmacological research shows that the phenolic acid possesses anti-oxidation effect and anti-myocardial ischemia effect. According to the invention, the salvianolic acid L induces the apoptosis of tumor cells and also can kill the tumor cells. Animal experiments show that salvianolic acid L possesses certain antineoplastic activity and does not appear toxicity, and is capable of substantially enhancing antineoplastic activity of various tumor medicines 5-fluorouracil, mitomycin C and the like, the compound is expected to be used for clinical tumor treatment.

Description

technical field [0001] The present invention relates to the antitumor application of plant extract or chemically synthesized phenolic acid component salvianolic acid L and its pharmaceutically acceptable salts, solvates and hydrolyzable ester preparations, including antitumor application alone, and combined with multiple A tumor drug is used for clinical tumor treatment. Background technique [0002] Salvia miltiorrhiza is the root of Salvia genus Lamiaceae. It is bitter in nature and slightly cold. Modern pharmacological studies have proved that Danshen can expand coronary arteries, improve microcirculation, protect the heart, inhibit and relieve platelet aggregation, improve the body's ability to withstand hypoxia, and have anti-hepatitis, anti-tumor, and anti-virus activities. In 2001, the Institute of Materia Medica, Chinese Academy of Medical Sciences, Union Medical University reported 13 phenolic acid compounds of the water-soluble active ingredients of Salvia miltior...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/216A61P35/00A61K31/513A61K31/407A61K31/4188
Inventor 周水平马晓慧张莉华颜璐璐王晶李秋影靳元鹏陈晓鹏
Owner TIANJIN TASLY PHARMA CO LTD
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