Film coating agent for treating onychomycosis and preparation method thereof

Abstract

The invention discloses a film coating agent for treating onychomycosis and a preparation method thereof, which relate to a film coating agent and a preparation method thereof. The film coating agent is prepared from a main medicament, a plasticizer, a penetration enhancer, a film forming agent and a medicament solvent. The method comprises the following steps of: weighing raw materials; mixing the film forming agent with water to obtain a substance A, and adding the plasticizer to obtain a colloid B; adding the main medicament into the medicament solvent for performing ultrasonic dissolving, and adding the permeation enhancer to obtain a substance C; and adding the substance C into the colloid B, mixing uniformly, and adjusting a pH value to 5.0 to obtain the film coating agent. The film coating agent for treating onychomycosis disclosed by the invention has the advantages of capability of directly penetrating nail sheets to the deep of connective tissues of nail bed parts for killing fungi and treating onychomycosis, high effective medicament concentration, high transdermal capability, remarkable curative effect, no irritation, no toxic or side effect, capability of completely curing onychomycosis, clinical administration safety, freeness from untoward reactions and reliable curative effect. The preparation method of the film coating agent for treating onychomycosis has the advantages of simple process, simple and convenient content measuring method, stable quality and suitability for medicinal industrial production.

Description

technical field [0001] The invention relates to a coating agent and a preparation method thereof. Background technique [0002] Onychomycosis, also known as onychomycosis, is a superficial fungal disease caused by dermatophytes invading the nail plate. The incidence rate accounts for more than 10% of superficial fungal diseases. . Onychomycosis (toe) nails can have varying degrees of negative effects on the quality of life and psychological state of patients. Onychomycosis is clinically manifested as thickening, unevenness, brittleness and deformation of the diseased nail. Because the nail plate is thicker, it is difficult to cure once infected. Existing topical medicines for the treatment of onychomycosis (finger fungus / toenail) have poor penetration to the nail plate, and cannot penetrate the protective layer on the nail surface to penetrate under the nail or into the deep layer of the nail plate to kill the fungus. Slow effect, short drug effect time, difficult to cure...

AI Technical Summary

Problems solved by technology

The clinical manifestations of onychomycosis are thickening, unevenness, brittleness and deformation of the nail. Due to the thick nail plate, once infected, it is not easy to cure

Existing topical medicines for the treatment of onychomycosis (finger fungus / toenail) have poor penetration to the nail plate, and cannot penetrate the protective layer on the nail surface to penetrate under the nail or into the deep layer of the nail plate to kill the fungus. Slow effect, short drug effect time, difficult to cure, easy to relapse, and oral antifungal drug treatment is easy to cause side effects and drug interactions

Thereby for a long time, onychomycosis patient lacks a kind of effective medicine that can treat both symptoms and root causes of onychomycosis, therefore, provide a kind of curative effect definite, safe and convenient, the medicine for the treatment of onychomycosis that short course of treatment, little side effect appears very important

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