Film coating agent for treating onychomycosis and preparation method thereof
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A film coating agent and onychomycosis technology, applied in the field of film coating agent and its preparation, can solve the problems of killing fungi, poor penetration, interaction, etc., and achieve increased film forming ability, good film forming performance, and strong penetration Effect
Inactive Publication Date: 2012-06-13
哈尔滨乐泰生物科技有限公司
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The clinical manifestations of onychomycosis are thickening, unevenness, brittleness and deformation of the nail. Due to the thick nail plate, once infected, it is not easy to cure
Existing topical medicines for the treatment of onychomycosis (finger fungus/toenail) have poor penetration to the nail plate, and cannot penetrate the protective layer on the nail surface to penetrate under the nail or into the deep layer of the nail plate to kill the fungus. Slow effect, short dr
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specific Embodiment approach 1
[0020] Specific embodiment one: present embodiment treats the coating agent of onychomycosis by weight and number ratio by the principal agent of 11~30 parts, the plasticizer of 3~8 parts, the penetration enhancer of 1~5 parts, 3~8 parts It is made of 49-82 parts of film-forming agent and 49-82 parts of drug solvent; the main ingredients are terbinafine, fluconazole, ketoconazole, clotrimazole, griseofulvin, amphotericin B, salicylic acid , amorolfine, bifonazole, ciclopirox olamine, povidone-iodine or a mixture of several; the plasticizer is one of glycerin, propylene glycol, sorbitol, polyethylene glycol-400 One or more mixtures; penetration enhancers are lauryl alcohol, azone, borneol, camphor, isopropyl myristate, ethanol, glycerin, isopropanol, PEG-400, dodecyl methyl sulfoxide, urea , EDTA-2Na or a mixture of several; the film-forming agent is polyvinyl alcohol, polyvinylpyrrolidone, CMC-Na, HPMC, polyethylene glycol, gelatin, carbomer, corn gluten, polyvinyl alcohol On...
specific Embodiment approach 2
[0022] Specific embodiment two: the difference between this embodiment and specific embodiment one is that the coating agent for the treatment of onychomycosis consists of 12 to 28 parts of main drug, 4 to 7 parts of plasticizer, 2 to 4 parts by weight. It is made from 50-80 parts of permeation enhancer, 4-7 parts of film-forming agent and 50-80 parts of drug solvent. Others are the same as in the first embodiment.
specific Embodiment approach 3
[0023] Specific embodiment three: what this embodiment is different from specific embodiment one is that the coating agent for the treatment of onychomycosis consists of 15 parts of main agent, 5 parts of plasticizer, 3 parts of penetration enhancer, 5 parts of film-forming agent and 60 parts of drug solvent. Others are the same as in the first embodiment.
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Abstract
The invention discloses a film coating agent for treating onychomycosis and a preparation method thereof, which relate to a film coating agent and a preparation method thereof. The film coating agent is prepared from a main medicament, a plasticizer, a penetration enhancer, a film forming agent and a medicament solvent. The method comprises the following steps of: weighing raw materials; mixing the film forming agent with water to obtain a substance A, and adding the plasticizer to obtain a colloid B; adding the main medicament into the medicament solvent for performing ultrasonic dissolving, and adding the permeation enhancer to obtain a substance C; and adding the substance C into the colloid B, mixing uniformly, and adjusting a pH value to 5.0 to obtain the film coating agent. The film coating agent for treating onychomycosis disclosed by the invention has the advantages of capability of directly penetrating nail sheets to the deep of connective tissues of nail bed parts for killing fungi and treating onychomycosis, high effective medicament concentration, high transdermal capability, remarkable curative effect, no irritation, no toxic or side effect, capability of completely curing onychomycosis, clinical administration safety, freeness from untoward reactions and reliable curative effect. The preparation method of the film coating agent for treating onychomycosis has the advantages of simple process, simple and convenient content measuring method, stable quality and suitability for medicinal industrial production.
Description
technical field [0001] The invention relates to a coating agent and a preparation method thereof. Background technique [0002] Onychomycosis, also known as onychomycosis, is a superficial fungal disease caused by dermatophytes invading the nail plate. The incidence rate accounts for more than 10% of superficial fungal diseases. . Onychomycosis (toe) nails can have varying degrees of negative effects on the quality of life and psychological state of patients. Onychomycosis is clinically manifested as thickening, unevenness, brittleness and deformation of the diseased nail. Because the nail plate is thicker, it is difficult to cure once infected. Existing topical medicines for the treatment of onychomycosis (finger fungus / toenail) have poor penetration to the nail plate, and cannot penetrate the protective layer on the nail surface to penetrate under the nail or into the deep layer of the nail plate to kill the fungus. Slow effect, short drug effect time, difficult to cure...
Claims
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