Method for preparing spinal cord injury repair tissue engineering stent

A tissue engineering scaffold, spinal cord injury technology, applied in medical science, prosthesis and other directions, can solve the problem of not being able to make models, and achieve the effect of good mechanical properties and good connectivity

Inactive Publication Date: 2012-06-27
浙江万泰特钢有限公司
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  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The traditional method of using models to make brackets has problems such as the inability to make arbitrary complex models, ofte

Method used

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  • Method for preparing spinal cord injury repair tissue engineering stent
  • Method for preparing spinal cord injury repair tissue engineering stent
  • Method for preparing spinal cord injury repair tissue engineering stent

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Embodiment Construction

[0018] The present invention will be further described below in conjunction with the accompanying drawings.

[0019] 1) Using low-temperature forming technology, a three-dimensional structure of any shape can be manufactured according to the required mold shape. The specific steps are as follows (such as figure 1 ), with the help of 3D CAD software to directly design or use solid reverse engineering to collect the geometric shape and structure information of the spinal cord prototype, and obtain the 3D model of the spinal cord.

[0020] The three-dimensional model scaffold of the spinal cord is composed of three parts, including gray matter functional area, isolation area and white matter functional area, such as figure 2 As shown, the macroscopic pores of the gray matter functional area are smaller than those of the white matter functional area; the macroscopic pores of the isolation area are the smallest, mainly functioning as isolation, which can prevent the movement of ce...

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Abstract

The invention relates to a method for preparing a spinal cord injury repair tissue engineering stent. The problems that any complicated model cannot be made, a requirement of a spinal cord bracket model cannot be met, and the porosity is low exist in the conventional method. According to the method, an in-vivo biotic environment is used as an important basis for designing a tissue engineering spinal cord stent by adopting a low temperature forming technology and a porogenic agent leaching process; the spinal cord bracket is partitioned into a grey matter induction functional region and a white matter induction functional region by using a microporous isolation layer with a small size by simulating a spinal cord structure and a living environment, so that the tissue engineering spinal cord stent is made; and an aim of respective regeneration is fulfilled by planting different seed cells and growth factors by using two different biotic environments. According to the method, a made mellow and full and regular stent has macroscopical pores with good penetration property, contains a large quantity of irregular microporous structures, has the average porosity of 89.92 percent and better mechanical property, and can meet the requirement of the tissue engineering spinal cord stent.

Description

technical field [0001] The invention belongs to the technical field of medical tissue engineering and low-temperature forming, and in particular relates to a preparation method of a spinal cord injury repairing tissue engineering bracket. Background technique [0002] In the 1980s, American scholars Langer and Vacanti proposed a new concept of tissue engineering regenerative medicine. Tissue engineering technology is currently the most ideal human organ replacement and repair technology. It is the application of engineering and life science principles and methods to prepare biological Active artificial substitutes used to maintain, restore or improve some or all of the functions of human tissues and organs. The basic principle and method of tissue engineering is to adsorb normal tissue cells cultured and expanded in vitro on a biomaterial with excellent cytocompatibility and can be degraded and absorbed by the body to form a complex, and then plant the cell-biomaterial compl...

Claims

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Application Information

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IPC IPC(8): A61F2/02
Inventor 史廷春陈美花蔡建辉胡弦安晓郑文祥王瑞艳张毅
Owner 浙江万泰特钢有限公司
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