Unlock instant, AI-driven research and patent intelligence for your innovation.

Powder injection of cefozopran hydrochloride composition for injection

A kind of technology of cefazolam hydrochloride and injection powder, which is applied in the field of medicine

Inactive Publication Date: 2012-06-27
SHANDONG LUOXIN PARMACEUTICAL GROUP STOCK CO LTD
View PDF3 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when the powder for injection of cefazolam hydrochloride is injected, it is often accompanied by pain.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Powder injection of cefozopran hydrochloride composition for injection
  • Powder injection of cefozopran hydrochloride composition for injection
  • Powder injection of cefozopran hydrochloride composition for injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1 The powder for injection of cefozopran hydrochloride composition provided by the present invention

[0025] Accurately weigh 500g of cefozopran hydrochloride, 103g of anhydrous sodium carbonate, 60g of sodium chloride, 7.92g of lidocaine hydrochloride, pass through an 80-mesh sieve, mix, fine filter, fill, and then pre-freeze at -55°C , the pre-freezing time is 1 hour; the sublimation temperature is -35° C., the sublimation time is 5 hours; the drying temperature is 15° C., and the drying time is 15 hours. Freeze-drying is carried out to prepare the cefozopran hydrochloride composition powder for injection.

Embodiment 2

[0026] Embodiment 2 The powder for injection of cefozopran hydrochloride composition provided by the present invention

[0027] Accurately weigh 500g of cefozopran hydrochloride, 103g of anhydrous sodium carbonate, 60g of sodium chloride, and 9.9g of lidocaine hydrochloride, pass through an 80-mesh sieve, mix, fine filter, fill, and then pre-freeze at -30°C , the pre-freezing time is 4 hours; the sublimation temperature is -10° C., the sublimation time is 20 hours; the drying temperature is 50° C., and the drying time is 3 hours. Freeze-drying is carried out to prepare the cefozopran hydrochloride composition powder for injection.

Embodiment 3

[0028] Embodiment 3 The powder for injection of cefozopran hydrochloride composition provided by the present invention

[0029]Accurately weigh 1000g of cefazolam hydrochloride, 206g of anhydrous sodium carbonate, 120g of sodium chloride, 16.8g of lidocaine hydrochloride, pass through a 100-mesh sieve, mix, fine filter, fill, and then pre-freeze at -45°C , the pre-freezing time is 4h; the sublimation temperature is -20°C, the sublimation time is 10h; the drying temperature is 30°C, and the drying time is 6h, and freeze-drying is carried out to prepare the cefozopran hydrochloride composition powder for injection.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the technical field of medicines and particularly relates to a powder injection of a cefozopran hydrochloride composition for injection. The powder injection of the cefozopran hydrochloride composition for injection consists of cefozopran hydrochloride, anhydrous sodium carbonate, sodium chloride and lidocaine hydrochloride. A mass ratio of the cefozopran hydrochloride to the anhydrous sodium carbonate to the sodium chloride to the lidocaine hydrochloride is 500:103:60:(7.92-9.9). According to the powder injection of the cefozopran hydrochloride combination for injection provided by the invention, the pain in injection is reduced. Compared with a positive control medicine group, the powder injection has the advantage that the compliance of a patient and a curative effect are obviously improved.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a powder for injection of a cefozopram hydrochloride composition. Background technique [0002] Bacterial infectious diseases are common and frequently-occurring diseases in people's daily life, and antibiotics are often used to treat them clinically. In recent years, due to the abuse of antibiotics, the problem of bacterial resistance has become more and more prominent, and new and more effective antibacterial drugs are needed to supplement or replace clinically. [0003] Cefazolam hydrochloride, the chemical name is (6R,7R)-7-[(Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyimino Acetamido]-3-(1H-imidazo[1,2-b]pyridazin-4-ium-1-yl)methyl-8-oxo-5-thio-1-azabicyclo[4.2. 0] Octyl-2-enyl-2-carboxylic acid. Monohydrochloride, the molecular formula is C 19 h 17 N 9 o 5 S 2 HCl, molecular weight: 551.99, structural formula as follows: [0004] [0005] As the fourth-generat...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/14A61K31/546A61K47/18A61P31/04
Inventor 李明杰朱全明王春艳
Owner SHANDONG LUOXIN PARMACEUTICAL GROUP STOCK CO LTD