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Application of interferon lambda1 in preparation of anti-enterovirus 71 medicines

A technology of enterovirus and interferon, which is applied in the field of biomedicine, can solve the problem of no immune-mediated negative effects, and achieve good results, cost savings, and high reproducibility

Inactive Publication Date: 2012-06-27
WUHAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Results from Phase 1a and 1b studies appear to be objective with no apparent immune-mediated side effects

Method used

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  • Application of interferon lambda1 in preparation of anti-enterovirus 71 medicines
  • Application of interferon lambda1 in preparation of anti-enterovirus 71 medicines
  • Application of interferon lambda1 in preparation of anti-enterovirus 71 medicines

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Embodiment Construction

[0024] Below in conjunction with specific embodiment, further illustrate the present invention. For the experimental methods without specific experimental conditions indicated in the following examples, conventional experimental conditions are generally followed, such as the experimental conditions described in "Molecular Cloning: A Laboratory Manual" edited by Sambrook et al., or the experimental conditions suggested by the manufacturer.

[0025] One: The establishment of a rapid detection method (Real-time PCR) for EV71 copy number

[0026] 1 Materials: Plasmids, viruses and cells

[0027] pCMV-Tag2B-VP1: It is a eukaryotic expression plasmid carrying the EV71 VP1 gene fragment, which was constructed by Song Yu in our laboratory.

[0028] EV71: It was isolated from the brain of a child who died of EV71 infection in Xiangfan City, Hubei Province, and was preserved in our laboratory.

[0029] Its sequence has not yet been uploaded to the NCBI database.

[0030] Rhabdomyosar...

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Abstract

The invention discloses an application of interferon lambda 1 in preparation of anti-enterovirus 71 medicines and confirms that the interferon lambda 1 (IFN-lambda 1) has a positive effect of virus replication inhabitation on rhabdomyosarcoma (RD) cells infected by enterovirus 71. Meanwhile, IFN-lambda 1 cannot inhibit the growth of RD cells and is confirmed to be nontoxic to the cells. The effect for inhibiting EV71 replication of IFN-lambda 1 is relatively approximate to or even better than positive control I interferon IFN-alpha. IFN-lambdas (including IFN-lambda 1, IFN-lambda 2 and IFN-lambda 3) have such biological activities as anti-virus and anti-cancer approximate to I type interferon and immune regulation and the like, can reduce side effects caused by the I type interferon and proclaims that IFN-lambda 1 has the prospect of being developed to be anti-enterovirus 71 medicines.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to the application of interferon lambda 1 in the preparation of anti-enterovirus 71 drugs. Background technique [0002] New enteroviruses refer to enterovirus types 68-71 newly discovered in recent years, which are picorna viruses and have the physical and chemical characteristics of enteroviruses. The new type of enterovirus can affect every system of the body. New enterovirus infections are prevalent and spreading all over the world, especially in Southeast Asia and my country in recent years. The hand, foot and mouth disease that is prevalent in infants and young children is mainly caused by enterovirus type 71 (EV71). Enterovirus type 71 (enterovirus type 71, EV71) belongs to Picornaviridae human enterovirus A serotype. The EV71 virus mainly infects infants and young children, and can cause herpes on the hands, feet, mouth and other parts of infants and young children. A few can caus...

Claims

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Application Information

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IPC IPC(8): A61K38/21A61P31/14
Inventor 朱应吴建国徐秀鹏蔡艳艳
Owner WUHAN UNIV
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