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Medicine composition for treating ischemic heart disease

A technology for ischemic heart disease and composition, applied in the field of medicine to achieve outstanding effects

Inactive Publication Date: 2012-07-04
INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The combination of Danshen Fang and Panshanlong, that is, the combination of Danshen, Panax notoginseng, borneol, and Panshanlong four herbs, this combination and the indications after the combination have not been reported in the research

Method used

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  • Medicine composition for treating ischemic heart disease
  • Medicine composition for treating ischemic heart disease
  • Medicine composition for treating ischemic heart disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] [Example 1] Preparation of Danshen Extract

[0025] According to the 2010 edition of the Chinese Pharmacopoeia, 1 kg of Salvia miltiorrhiza medicinal materials were crushed into coarse powder, and extracted with 6 times the amount of 80% ethanol for 1.5 hours, filtered, and the medicinal residue was refluxed with 50% ethanol for 1.5 hours, filtered, and the medicinal residue was added with water Decocted for 2h, filtered, combined the filtrate and concentrated to an appropriate amount, dried, and then obtained. According to the content measurement method in the Pharmacopoeia, the content of salvianolic acid B was 7.6% and the content of tanshinone was 0.31%, which meets the requirements of compound Danshen tablets. Quality control of Zhongdanshen.

Embodiment 2

[0026] [Example 2] Preparation of Panax Notoginseng Saponins

[0027] According to the 2010 edition of "Chinese Nadian", 1kg of Panax notoginseng medicinal material was crushed into coarse powder, and extracted twice with 6 times the amount of 70% ethanol at reflux for 1 hour each time. The extracts were combined, filtered, and the filtrate was concentrated under reduced pressure and loaded. It is eluted with macroporous adsorption resin and 80% ethanol. The eluate is decolorized and concentrated under reduced pressure, refined and dried to obtain it. After UV detection, the content of total saponins is 96.49%, of which ginsenoside Rb1 is 32.19% and ginsenosides Rg1 is 31.06%, and notoginsenoside R1 is 7.49%.

Embodiment 3

[0028] [Example 3] Preparation of Panzanosaurus Saponins

[0029] Take 1 kg of Chrysanthemum chinense medicinal material and crush it into coarse powder, extract twice with 6 times the amount of 70% ethanol and 0.5% alkali solution, each time for 1 hour, combine the extracts, filter, adjust the acid to neutral, and concentrate the filtrate under reduced pressure to extract , Dry, ready to be obtained, according to the 2005 edition of the Chinese Pharmacopoeia appendix VIC, accurately take an appropriate amount of the dried product, and pass it through a neutral alumina column. The content of water-soluble saponin in the total saponins of Chlorophyllum saponins is 52.16%.

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Abstract

The invention belongs to the technical field of medicines and provides a Chinese medicine composition for treating an ischemic heart disease. The composition comprises an extract from Salvia miltiorrhiza, panax notoginseng saponins, borneol and water-soluble total saponin from Dioscorea nipponica and is obtained by adding the total saponin from the Dioscorea nipponica on the basis of a compound Salvia miltiorrhiza formula. Verified by a rat myocardial ischemia reperfusion injury animal experiment, the effect of the composition for treating the ischemic heart disease is superior to that of the compound Salvia miltiorrhiza tablets; furthermore, the medicine is economic and simple; and experimental basis is provided for secondarily developing the compound Salvia miltiorrhiza tablets and researching the novel Chinese medicine compound with regard to cardiovascular diseases.

Description

Technical field [0001] The invention relates to a traditional Chinese medicine drug combination and a preparation method of the combination, in particular to the combination that can significantly protect and treat myocardial ischemia reperfusion injury diseases, and belongs to the technical field of medicine. Background technique [0002] Ischemic heart disease includes coronary artery obstruction or stenosis caused by atherosclerotic lesions. Myocardial infarction is a common clinical ischemic heart disease. In recent years, with the development of interventional technology, the treatment of acute myocardial infarction has also entered a new stage of development. Interventional therapy of acute myocardial infarction is a rapid development in recent years. The new technology quickly penetrates the embolized coronary artery through interventional surgery and restores blood flow to improve the blood and oxygen supply of the patient’s myocardium, save more frequent necrosis of the ...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61P9/10
Inventor 王升启潘从泽王云飞孔祥娟洪婷郑冰清
Owner INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
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