Preparation technology and production method of novel dual-purpose decoction integrated dosage form

A production method and a technology for a new dosage form are applied in the field of preparation of a new integrated dosage form of Eryi Decoction to achieve the effects of wide target distribution and strong slow and controlled release performance.

Inactive Publication Date: 2012-07-04
SUZHOU ZHIWEITANG BIOLOGICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The domestic and foreign databases were used to search for novelties, and the following conclusions were drawn based on the reading, analysis and comparison of domestic and foreign literature: the innovation of the project of "developing new integrated dosage forms of nano-drugs with combined technology": 1) the use of nano-scale traditional Chinese medicine rich in trace elements Nanospheres, nanocapsules, polymer micelles, and solid ester nanoparticles of different particle sizes are prepared with different drug carriers such as powder, drug monomer, effective part, effective part group, traditional Chinese medicine extract, decoction concentrate, etc. , magnetic nanoparticles, immune nanoparticles, nanoemulsions, suspensions, vesicles, dru

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0048] [Example 1]

[0049] The following raw materials were prepared according to the aforementioned method: extract, nanoparticles, microcapsules, and nanoparticles.

[0050] The composition of the raw materials made into the active ingredients according to the weight ratio is ——

[0051] 4.4 parts of Guixin, 4 parts of dried ginger, 30 parts of licorice, 4.4 parts of almonds.

[0052] The manufacturing process is as follows: After mixing the extract, nanoparticles, microcapsules, and nanoparticles in a 4:2:2:2 ratio in a GMP10000 clean room, use the 2010 edition of the "Chinese Pharmacopoeia" Part I preparations and hard capsules Standard, no auxiliary materials and preservatives are added, and hard capsules are filled with an automatic capsule filling machine to make hard capsules. Then carry out internal and external packaging such as counting, bottling, sealing, sticking labels, coding, and packing. Finally, uniform instant sterilization according to the production batch, and ...

Example Embodiment

[0053] [Example 2]

[0054] The following raw materials were prepared according to the aforementioned method: decoction concentrate, nano liposomes, nano emulsions, and micro emulsions.

[0055] The composition of the raw materials made into the active ingredients according to the weight ratio is ——

[0056] 4.4 parts of Guixin, 4 parts of dried ginger, 30 parts of licorice, 4.4 parts of almonds.

[0057] The manufacturing process is as follows: After mixing the decoction concentrate, nanoliposomes, nanoemulsions, and microemulsions at a ratio of 4:2:2:2 in a GMP10000 clean room, use the first preparation of the 2010 Chinese Pharmacopoeia Some soft capsules are standard, no auxiliary materials and preservatives are added, and the soft capsules are divided into soft capsules by the automatic soft capsule filling machine. Then carry out internal and external packaging such as counting, bottling, sealing, sticking labels, coding, and packing. Finally, uniform instant sterilization acco...

Example Embodiment

[0058] 〖Example three〗

[0059] The following raw materials were prepared according to the aforementioned method: extract, nano-particles, and nano-emulsion.

[0060] The composition of the raw materials made into the active ingredients according to the weight ratio is ——

[0061] 4.4 parts of Guixin, 4 parts of dried ginger, 30 parts of licorice, 4.4 parts of almonds.

[0062] The manufacturing process is as follows: After mixing the extract, nanoparticles, and nanoemulsions in a 4:3:3 ratio in a GMP10000 clean room, adopt the 2010 edition of the "Chinese Pharmacopoeia" Part I of the preparation and partial film standards, and the film forming materials are used Polyvinyl alcohol, made into film. Then carry out inner and outer packaging such as boxing, sealing, sticking labels, coding, and boxing. Finally, uniform instant sterilization according to the production batch, and issue a sterilization report. The area of ​​each film is 2-40 square centimeters, and each film is applied f...

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PUM

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Abstract

The invention relates to a preparation technology and a production method of a novel dual-purpose decoction integrated dosage form. The novel dual-purpose decoction integrated dosage form consists of the following raw material active ingredients in parts by weight: 4.4 parts of cassia bark core, 4 parts of dried ginger, 30 parts of liquoric root and 4.4 parts of apricot kernel. The production process comprises ultrasonic speed fluid energy milling, alcohol-water extraction, ultrasonic wave smashing and extracting, water decoction concentration, ultrasonic speed spray drying, nanometer grinding, high-pressure homogenization, nanoparticle preparation and the like. In the invention, the advantages of multi-coordination, multi-targeting and the like represented in a nano-carrier coupling technique are utilized. After large-scale production is performed, the production cost can be reduced greatly, the product quality can be enhanced greatly, and the targeting property and controlled release property of a medicament can be enhanced. A dual-purpose decoction can be administrated internally and externally, and can be taken at four time intervals according to midnight-noon ebb-flow and the qi-blood flow rule of a human body. The dual-purpose decoction can be prepared into a film forming agent and a transdermal agent which are attached to different positions of a human body respectively according to midnight-noon ebb-flow and the qi-blood flow rule of the human body and can be directly absorbed through skin.

Description

technical field [0001] The invention relates to a preparation technology of a new integrated dosage form of Eryi Decoction, and also relates to a preparation technology of a new integrated dosage form of Eryi Decoction and a production method thereof. Background technique [0002] Due to too many chemical components, the chemical reaction of compound decoction of traditional Chinese medicine has not yet been revealed its mysterious veil, but some mysterious black boxes of medicinal effects in traditional Chinese medicine prescriptions are hidden in the decoction of traditional Chinese medicine. Traditional Chinese medicine is modernized and only uses monomers and effective parts. Chinese herbal decoction concentrate cannot be discarded! When the traditional Chinese medicine prescription is decocted in water, due to the high temperature when the prescription is decocted together and the complex chemical environment in the solution, complexation, hydrolysis, oxidation, reduct...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/00A61P1/12A61P1/00
Inventor 杨洪舒
Owner SUZHOU ZHIWEITANG BIOLOGICAL TECH
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