Method for preparing 2-aldehyde oxazole
An aldehyde-based oxazole and oxazole technology, which is applied in the field of preparing oxazole compounds, can solve the problems of unsuitable storage and transportation, cumbersome post-processing, low yield and the like, and achieves easy storage and transportation, simple post-processing method, and low yield. Conditionally stable effects
Active Publication Date: 2012-07-04
LIAONING ASYMCHEM LAB CO LTD
View PDF4 Cites 1 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
At this stage, the method for preparing 2-formyl oxazole is mainly the organolithium reagent method. First, the lithiation reaction of oxazole and organolithium occurs, and then reacts with N,N-dimethylformamide or N-formylmorpholine On the aldehyde group, the post-treatment of these two methods is relatively cumbersome. The method of using N,N-dimethylformamide on the aldehyde group needs to obtain the product through silica gel column chromatography. Because the product has a low boiling point and high water solubility The characteristics of this method lead to a very low yield. This method is not suitable for large-scale production. The product obtained is an oily mixture by using the method of N-formylmorpholine reaction on the aldehyde group. The pure product compound of the product cannot be obtained, and it is not suitable for storage and transport
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreExamples
Experimental program
Comparison scheme
Effect test
Embodiment 1
Embodiment 2
Embodiment 3
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More PUM
Login to View More
Abstract
The invention relates to a method for preparing 2-aldehyde oxazole, comprising the steps of selecting commercial material on the market or easily-prepared oxazole as original raw material; dropping n-butyllithium to the organic phase solution of the main material oxazole at low temperature; and adding N-formoxyl piperidine to the reaction system, and obtaining solid lithium salt with high nuclear magnetic purity. The nuclear magnetic purity is higher than 98.0% stably and the yield is 75.0-85.0%. The synthetic method for obtaining 2-aldehyde oxazole by diluted acid hydrolysis has stable process condition, moderate chemical reaction conditions, simple operation and low pollution during the whole production and provides a new idea and a method for preparing 2-aldehyde oxazole.
Description
(1) Technical field: The invention relates to a method for preparing oxazole compounds, in particular to a method for preparing 2-formyl oxazole. (two) background technology: Oxazole is a five-membered ring containing O and N atoms in the 1 and 3 positions. It is a liquid with a pyridine-like odor and is easily soluble in water. It is a very stable compound. It is very stable in hot strong acids and does not undergo self-oxidation. reaction and does not participate in any normal biochemical process. Oxazole compounds are a class of important heterocyclic compounds. Some compounds with oxazole rings have biological activity, and they are also widely used in intermediates and drug synthesis. Oxazole-2-carboxaldehyde is to increase an aldehyde group substitution on the oxazole ring, which increases the reactivity of oxazole, and can be synthesized by a conventional biochemical process to have a biologically active compound with an oxazole ring. In intermediates, It has a wide...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More Application Information
Patent Timeline
Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07D263/32
Inventor 洪浩卢江平汪胜华
Owner LIAONING ASYMCHEM LAB CO LTD
Who we serve
- R&D Engineer
- R&D Manager
- IP Professional
Why Eureka
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Social media
Eureka Blog
Learn More Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com