The invention provides a method for preparing 5-methylprazine-2-
carboxylic acid. The preparation method comprises the steps: using 5-methyl-2and3-
pyrazine 2-
carboxylic acid as
raw material, carrying The invention provides a method for preparing 5-methylprazine-2-
carboxylic acid. The preparation method comprises the steps: using 5-methyl-2and3-
pyrazine 2-carboxylic acid as
raw material, carryingout photophobism reaction in a saturated
saline solution, and obtaining 5-methylprazine-2-carboxylic acid as a final product. The preparation method optimizes the process from the source on the basisout photophobism reaction in a saturated
saline solution, and obtaining 5-methylprazine-2-carboxylic acid as a final product. The preparation method optimizes the process from the source on the basisof the principle of water
decarboxylation, thereby being a method for effective
decarboxylation in a
saline solution at lower temperature. Moreover, in the preparation method, no
organic solvent is adof the principle of water
decarboxylation, thereby being a method for effective decarboxylation in a saline solution at lower temperature. Moreover, in the preparation method, no
organic solvent is added in the
chemical reaction, no
pollution is generated, the condition is mild, the reaction in the whole technological process has no high temperature,
high selectivity and few by-products, thus theded in the
chemical reaction, no
pollution is generated, the condition is mild, the reaction in the whole technological process has no high temperature,
high selectivity and few by-products, thus thepreparation method is a simple and available
pollution-free method which has the capability of large-scale production.preparation method is a simple and available pollution-free method which has the capability of large-scale production.