30results about How to "Mild chemical reaction conditions" patented technology

The invention relates to a synthesizing method, partial intermediate products and final products of a chiral beta-alkamine derivative. The synthesizing method of the chiral beta-alkamine derivative is characterized by comprising the steps of: selecting commercialized materials in the market and NH2R2 as initial materials, wherein R2 is a Cl-C6 alkyl group, a C3-C6 naphthenic base and an aryl group or an aryloxy; obtaining the intermediate products and the final products through a chemical reaction process with moderate conditions, wherein R1 and R2 are the Cl-C6 alkyl group, the C3-C6 naphthenic base and the aryl group or the aryloxy, and a chiral center is in an S or R shape. The invention has the advantages that the adopted materials are easy to obtain and at low price and can meet the requirements of large-scale production, chiral compounds are used as the initial materials, optical purity is retained in consequent reaction without finding racemization, and committed steps accord with the requirements of the current green chemistry; in addition, the invention has the advantages of simple synthesizing method, good selectivity, high yield coefficient, easy operation and good market benefits.

The invention provides a synthesis method of beta-amino acid derivative, and relative intermediate product, in particular to a synthesis method of formula (I) and relative intermediate product. The invention is characterized in that the invention uses commercialized material as formula (II) (trans-, E-type) as initial material, to obtain final product which formula is (III) via chemical reaction with mild condition. The invention has easily accessible starting material, stable technological condition and support for scaled industrial production.

The invention relates to reducing response magnetic drug-loaded nanoparticles with synergetic anti-cancer interaction and a preparation method of the reducing response magnetic drug-loaded nanoparticles. The drug-loaded nanoparticles are prepared from a polymer prodrug and inorganic nanoparticles, which are connected through a disulfide bond; and the inorganic nanoparticles include surface-aminated superparamagnetism ferroferric oxide nanoparticles (SPION-NH2) and aminated selenium nanoparticles (NH2-R-SeNPs) employing an amino-containing high polymer as a template. The preparation method specifically comprises the following steps: (1) mixing an SPION-NH2 solution with an NH2-R-SeNPs dispersing liquid and adjusting the pH value to be 4.5-5.5; (2) dissolving the polymer prodrug connected through the disulfide bond by using ultrapure water and adjusting the pH value to be 5; and (3) dropwise adding the solution obtained in step (1) to the solution obtained in step (2), adjusting the pH value of a system to be 7.4, stirring the solution at room temperature for 10-14h to obtain the reducing response magnetic drug-loaded nanoparticles with synergetic anti-cancer interaction. The drug-loaded nanoparticles have the advantages of specific responsiveness in a targeted area, synergetic interaction and a low toxic or side effect.

The invention provides a preparation method of a novel rosuavastatin calcium intermediate I which is suitable for industrial large-scale production. The preparation method comprises the step of enabling triphenyl methyl phosphorus bromide to react with a compound II, thus obtaining an intermediate I. The preparation method provided by the invention is safe and simple and is strong in operability, and a final finished product which is high in efficiency and purity can be obtained.

A synthetic method of 1,4-dioxane-2,5-diol is characterized in that concrete preparation comprises the following steps of: (1) feeding; (2) reacting; (3) post-processing; (4) preparation of the product. The invention has following advantages: 1, raw materials adopted in the invention are easily available and are cheap in price; the raw materials are all commercial raw materials or raw materials which are easy to prepare, and can satisfy the requirement of large scale production; 2, by the adoption of a simple hydrolysis reaction and simultaneously a batch charging method, the solvent amount is less, the energy and post-processing time are saved, the operation is simple, the synthetic method is suitable for large scale industrial production; 3, the condition of chemical reactions adopted in the invention is mild; there is no high temperature or low temperature reaction during the whole reaction process; during the production process, the technology is reasonable, the production is safe and reliable, and the cost is low; there is no environmental pollution; the synthetic method is suitable for large scale industrial production.

The invention relates to a method for synthesizing the derivatives of chiral pyridyl aminoalcohols, and intermediate products and final products of the same. Initial materials are selected from commercial raw materials on the market or easy-to-prepare raw materials of halogenated pyridine alkyl ketone or aromatic ring ketones, wherein X is F or Cl, R1 is C1 to C8 alkyls or C3 to C8 cycloalkyls; and final products are obtained through a process of chemical reactions under mild conditions, wherein R1 is C1 to C8 alkyls or C3 to C8 naphthene base, R2 is H or C1 to C8 alkyls, or C3 to C8 cycloalkyls or C7 to C9 benzyls, and chiral centers of alcohols have an S or R structure. The method provides a new thought and means for preparing the derivatives of chiral pyridyl aminoalcohols; the intermediate products are that the chiral centers of alcohols have an S or R structure; and the final products are that the chiral centers of alcohols have an S or R structure.

The invention discloses a monomer N-(p-acetenyl)-phenyl-2-X-tetrafluorobenzamide (X=F, Cl, Br and I) for identifying halogen anions, a polymer, and a method for preparing the monomer and the polymer. The method comprises the following steps: by taking 4-ethynylaniline and hexafluorobenzoic acid as main initial raw materials, taking N,N-dimethyl-4-aminopyridine as a catalyst, finally synthesizing a target small molecule compound N-(p-acetenyl)-phenyl-2-X-tetrafluorobenzamide; and by taking a precious metal complex Rh+(2,5-nbd)[(eta6-C6H5)B-(C6H5)3] (triphenyl-eta6-phenylboron-2,5-norborneol diene rhodium, Rh(nbd)BPh4) as a catalyst, thereby obtaining the poly-N-(p-acetenyl)-phenyl-2-X-tetrafluorobenzamide by virtue of a coordination polymer orientation method. The obtained small molecule monomer and polymer molecular structures simultaneously contain hydrogen bond donors and halogen bond donors, and the monomer and polymer can identify the halogen anions by virtue of coordination of hydrogen bonds and halogen bonds. Meanwhile, the preparation method has the advantages of the reaction conditions are mild, the reaction process is simple, the method is easy to control, the yield of the obtained product is high and the like.

The invention discloses a synthetic method of glycol mono-hydrogenated nopyl ether and carboxylic ester thereof and application thereof. The method comprises the following steps of adding hydrogenatednopyl halide and glycol into organic solvents; performing backflow reaction under the effect of hydroxide; after the reaction is completed, performing washing, drying, solvent recovery and vacuum distillation to obtain glycol mono-hydrogenated nopyl ether; then, performing backflow reaction on glycol mono-hydrogenated nopyl ether and carboxylic acid under the participation of catalysts and watercarrying agents; performing synthesis to obtain five kinds of glycol mono-hydrogenated nopyl ether carboxylic ester. The synthesized glycol mono-hydrogenated nopyl ether and the five kinds of glycol mono-hydrogenated nopyl ether carboxylic ester can be used for inhibiting plant pathogenic fungi. The compound has the advantages of safety, nontoxicity, low environment pollution and the like. The chemical reaction conditions are mild; the equipment is simple; the operation is simple and convenient; the product yield is high; the purity is high.

The present invention discloses a tetrahydropyrane-3-formic acid preparation method, wherein acrolein is adopted as a raw material, and the preparation method comprises the following three steps: (1) acrolein is subjected to a ring closure reaction under an acid effect to obtain 5,6-dihydro-2-H pyran-3-formaldehyde, (2) the 5,6-dihydro-2-H pyran-3-formaldehyde and hydrogen are subjected to a reduction reaction under a metal catalyst effect to obtain tetrahydropyrane-3 formaldehyde, and (3) the tetrahydropyrane-3 formaldehyde and a Jones reagent are subjected to an oxidation reaction to obtain tetrahydropyrane-3-formic acid.

The invention discloses a vildagliptin preparation method, and relates to the technical field of preparation of pyrrolidine heterocyclic compounds. The method comprises the following steps: 1, preparing an acetonitrile solution of S-1-chloroacetyl-2-cyanpyrrolidine; 2, adding acetonitrile into a reaction kettle, stirring, adding 3-amino-1-adamantanol, potassium carbonate and potassium iodide, heating, adding the acetonitrile solution of S-1-chloroacetyl-2-cyanpyrrolidine in a dropwise manner, and carrying out a heat insulation reaction after the dropwise addition until the reaction is completely carried out; and 3, post-processing: cooling, stirring, centrifuging, collecting the obtained filter cake, adding dichloromethane into the kettle, stirring, adding the filter cake, stirring, centrifuging, collecting the obtained filtrate, concentrating the filtrate to obtain a concentrate, re-crystallizing the concentrate by using isopropanol to obtain a crude product, carrying out hot washing on the crude product by using isopropanol, cooling, and centrifuging to obtain a product. The product is obtained through the one-step reaction by using the method, the yield is high, the chemical purity and the chiral purity are respectively greater than 99%, and the method has the advantages of short reaction time, low energy consumption and simple operation.