30results about How to "Mild chemical reaction conditions" patented technology

The invention discloses a synthesis method of a chiral epoxy compound and intermediate products and a final product beta-amino acid derivative. The chiral epoxy compound is obtained by utilizing commercialized raw materials in markets as initial raw materials and then obtaining a chiral intermediate in the process of chemical reaction under mild conditions. In the method, the novel chiral catalyst method is utilized, a great amount of novel chiral catalyst ligand is synthesized by adopting the method in documents, epoxidation is carried out on olefin and then olefin is applied to the synthesis of the beta-amino acid derivative, thereby improving the use ratio of raw materials and optimizing the process from the origin. Epoxidation is carried out on unsaturated amide by the novel chiral ligand, and then open-loop deprotection is carried out to obtain the product. The value of product obtained by oxidation reaction is 80-99%, the yield coefficient thereof is 80-95%, and the chemical purity thereof is 90-99%, therefore, the chiral epoxy compound can be used for mass production and has very good industrial value.

The invention belongs to the field of medicine synthesis and particularly relates to a doripenem preparation method. The method includes the steps that a compound 5 reacts with concentrated sulfuric acid in methanol to obtain a compound 4; the compound 4 and p-Nitrobenzyl-6-(1-hydroxyethyl)-1-azabicyclo(3.2.0)heptane-3,7-dione-2-carboxylate (a compound 3) are subjected to a condensation reaction under the condition that N,N-diisopropylethylamine exists, water and ethyl acetate are added and stirred after the reaction, an ethyl acetate layer is collected, alcohol is added in ethyl acetate collection liquid, crystallization is carried out, and a compound 2 is obtained; the product is dissolved through ethyl acetate; after a monopotassium phosphate solution and a phase transfer reagent of triethylbenzylammonium chloride are added, zinc powder is added into the ethyl acetate / monopotassium phosphate solution in batches to react and obtain doripenem. According to the method, reaction conditions are moderate, the technology is simple, and the conversion rate and the yield are high. Two-phase reaction is used in deprotection reaction, and the after-treatment process is simplified. The zinc powder which is cheap is used, so that the method is economical, and a new concept and a new method are provided for doripenem preparation.

A synthetic method of 1,4-dioxane-2,5-diol is characterized in that concrete preparation comprises the following steps of: (1) feeding; (2) reacting; (3) post-processing; (4) preparation of the product. The invention has following advantages: 1, raw materials adopted in the invention are easily available and are cheap in price; the raw materials are all commercial raw materials or raw materials which are easy to prepare, and can satisfy the requirement of large scale production; 2, by the adoption of a simple hydrolysis reaction and simultaneously a batch charging method, the solvent amount is less, the energy and post-processing time are saved, the operation is simple, the synthetic method is suitable for large scale industrial production; 3, the condition of chemical reactions adopted in the invention is mild; there is no high temperature or low temperature reaction during the whole reaction process; during the production process, the technology is reasonable, the production is safe and reliable, and the cost is low; there is no environmental pollution; the synthetic method is suitable for large scale industrial production.

The object of the present invention is to provide a kind of production technology of the glycine tert-butyl ester that is suitable for industrial production, this production technology is by adopting chloroacetate tert-butyl and ammoniating agent reaction, directly synthesized glycine tert-butyl ester successfully, has larger Implementation value and social and economic benefits, it is a production process of glycine tert-butyl ester suitable for industrial production with reasonable process, safe and reliable production, high reaction yield, low production cost and basically no three wastes, and suitable for large-scale industrial production.

The invention provides a preparation method of a novel rosuavastatin calcium intermediate I which is suitable for industrial large-scale production. The preparation method comprises the step of enabling triphenyl methyl phosphorus bromide to react with a compound II, thus obtaining an intermediate I. The preparation method provided by the invention is safe and simple and is strong in operability, and a final finished product which is high in efficiency and purity can be obtained.

The invention discloses a preparation method and application of a thermosetting epoxy resin shape memory polymer. The method comprises the steps of reacting epoxy resin, thiocyanic acid and a basic catalyst under vacuum conditions at 80 DEG C to 150 DEG C; followed by natural cooling to obtain a thermosetting epoxy resin shape memory polymer. The invention also provides a preparation method of a thermosetting epoxy resin shape-memory polymer material and a shape-memory restoration method. The thermosetting epoxy resin shape-memory polymer prepared by the method of the invention has good chemical stability and thermal stability, exhibits good shape-memory effect when its glass transition temperature is above its glass transition temperature, and has good mechanical properties.

The invention relates to a synthesis method of chiral 2,3-pinanediol. The structural formula of chiral 2,3-pinanediol is showed in the specification. The synthesis method comprises the step of adding an oxidation inhibitor and alkali liquor containing an oxidant in alpha-pinene which is commercialized in the market and selected as a starting material for reaction so that a final product, namely chiral 2,3-pinanediol, can be obtained. According to the method, a target product with high liquid phase purity and high ee (enantiomeric excess) value of a product enantiomer can be obtained, wherein the liquid phase purity is stabilized above 98%, the ee value of the enantiomer is stabilized above 99% and the yield is 60.7-76.6%. According to the synthesis method, the materials are easy to obtain, the price is cheap, the chemical reaction condition is mild during the production process, the technical condition is stable, the operation is simple, pollution is less; the synthesis method is suitable for on-scale production, and a new idea and method can be provided for preparing chiral 2,3-pinanediol.

The invention discloses a monomer N-(p-acetenyl)-phenyl-2-X-tetrafluorobenzamide (X=F, Cl, Br and I) for identifying halogen anions, a polymer, and a method for preparing the monomer and the polymer. The method comprises the following steps: by taking 4-ethynylaniline and hexafluorobenzoic acid as main initial raw materials, taking N,N-dimethyl-4-aminopyridine as a catalyst, finally synthesizing a target small molecule compound N-(p-acetenyl)-phenyl-2-X-tetrafluorobenzamide; and by taking a precious metal complex Rh+(2,5-nbd)[(eta6-C6H5)B-(C6H5)3] (triphenyl-eta6-phenylboron-2,5-norborneol diene rhodium, Rh(nbd)BPh4) as a catalyst, thereby obtaining the poly-N-(p-acetenyl)-phenyl-2-X-tetrafluorobenzamide by virtue of a coordination polymer orientation method. The obtained small molecule monomer and polymer molecular structures simultaneously contain hydrogen bond donors and halogen bond donors, and the monomer and polymer can identify the halogen anions by virtue of coordination of hydrogen bonds and halogen bonds. Meanwhile, the preparation method has the advantages of the reaction conditions are mild, the reaction process is simple, the method is easy to control, the yield of the obtained product is high and the like.

The invention relates to a method for synthesizing the derivatives of chiral pyridyl aminoalcohols, and intermediate products and final products of the same. Initial materials are selected from commercial raw materials on the market or easy-to-prepare raw materials of halogenated pyridine alkyl ketone or aromatic ring ketones, wherein X is F or Cl, R1 is C1 to C8 alkyls or C3 to C8 cycloalkyls; and final products are obtained through a process of chemical reactions under mild conditions, wherein R1 is C1 to C8 alkyls or C3 to C8 naphthene base, R2 is H or C1 to C8 alkyls, or C3 to C8 cycloalkyls or C7 to C9 benzyls, and chiral centers of alcohols have an S or R structure. The method provides a new thought and means for preparing the derivatives of chiral pyridyl aminoalcohols; the intermediate products are that the chiral centers of alcohols have an S or R structure; and the final products are that the chiral centers of alcohols have an S or R structure.

The invention relates to a synthesis method for a trans-form amantadine compound, which includes the steps of utilizing commercialize raw materials on the market or an easily prepared amantadine compound as initial materials, and carrying out reductive amination reaction between the initial raw materials and liquid ammonia under the action of a reductive agent and a catalyst, so that 100% of the trans-form amantadine compound, (wherein R refers to -H, -COOH, -OH, -SO2NH2, Cl and groups shown in the description) is obtained. The method has the advantages that raw materials are easy to obtain, both reaction purity and yield are high, loss of the trans-form amantadine compound is decreased by salifying for final treatment, production cost is reduced, and the method is applicable to large-scale production and provides a novel thinking for preparing the trans-form amantadine compound.

The invention provides a synthesis method of beta-amino acid derivative and a relative intermediate product, in particular to a synthesis method of the formula (I) and a relative intermediate product.The invention is characterized in that the invention uses commercialized material as formula (II) (trans-, E-type) as initial material, to obtain final product which formula is (III) via chemical reaction with mild condition. The invention has easily accessible starting material and stable technological condition, and is suitable for scaled industrial production.

The invention relates to a synthesizing method, partial intermediate products and final products of a chiral beta-alkamine derivative. The synthesizing method of the chiral beta-alkamine derivative is characterized by comprising the steps of: selecting commercialized materials in the market and NH2R2 as initial materials, wherein R2 is a Cl-C6 alkyl group, a C3-C6 naphthenic base and an aryl group or an aryloxy; obtaining the intermediate products and the final products through a chemical reaction process with moderate conditions, wherein R1 and R2 are the Cl-C6 alkyl group, the C3-C6 naphthenic base and the aryl group or the aryloxy, and a chiral center is in an S or R shape. The invention has the advantages that the adopted materials are easy to obtain and at low price and can meet the requirements of large-scale production, chiral compounds are used as the initial materials, optical purity is retained in consequent reaction without finding racemization, and committed steps accord with the requirements of the current green chemistry; in addition, the invention has the advantages of simple synthesizing method, good selectivity, high yield coefficient, easy operation and good market benefits.