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Sulfated polyacrylate emulsion and preparation method thereof

A technology of polyacrylate emulsion and polyacrylate, which is applied in the preparation of sulfated polyacrylate emulsion materials and the preparation of sulfated polyacrylate emulsions, can solve the problems affecting the separation and analysis effect of liquid chromatography medium and the particle size. Diameter size and pore size structure cannot be accurately controlled, particle size and pore size are not uniform, etc., to achieve the effect of easy continuous operation, uniform and stable emulsion, and uniform particle size.

Pending Publication Date: 2022-03-18
赛分科技扬州有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The particle size and pore size structure of microsphere fillers prepared by traditional methods cannot be precisely controlled, and the particle size and pore size are not uniform, which limits its practical application in liquid chromatography to a large extent, and seriously affects its use as a liquid phase. Separation and analytical performance of chromatographic media

Method used

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  • Sulfated polyacrylate emulsion and preparation method thereof

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preparation example Construction

[0030] The invention provides a kind of preparation method of sulfated polyacrylate emulsion, comprises following main steps:

[0031] S1 polyacrylate activation treatment, the pre-prepared polyacrylate-based balls with fixed components, particle size and pore size are subjected to acidic activation treatment to obtain activated polyacrylate microspheres; the particle size of the polyacrylate-based balls 15μm~90μm and the pore size is The acidic activation treatment uses concentrated sulfuric acid to prepare a 0.4M-0.6M concentrated sulfuric acid solution, and the polyacrylate-based balls are added to the concentrated sulfuric acid solution and stirred evenly to activate the polyacrylate-based balls. The stirring speed is 250rpm-350rpm, and the activation time is 60min~120min;

[0032] S2 The first bonding reaction, the activated polyacrylate microspheres are dispersed in the alkaline solution, and the alkylene oxide solution is added to carry out the first bonding reaction,...

Embodiment 1

[0050] The preparation method of a kind of sulfated polyacrylate emulsion provided in this embodiment, firstly, adopts polyglycidyl methacrylate-polyethylene glycol dimethacrylate copolymer base sphere prepared in advance, the copolymerized polyacrylic acid The particle size of ester-based balls is 45 μm ~ 60 μm and the pore size is Use concentrated sulfuric acid to prepare 0.5M concentrated sulfuric acid solution for acidic activation treatment, and add copolymerized polyacrylate base balls to the concentrated sulfuric acid solution and stir evenly to activate the base balls. The stirring speed is 280rpm, and the activation time is 100min to obtain activated polyacrylate. Copolymerized microspheres;

[0051] Secondly, carry out the bonding reaction for the first time to obtain the activated polyacrylate copolymerized microspheres, the copolymerized microspheres are dispersed in 30% NaOH alkaline solution, and add the epichlorohydrin solution of concentration 3.0%, at reactio...

Embodiment 2

[0058] The preparation method of a kind of sulfated polyacrylate emulsion provided in this embodiment, firstly, adopt the pre-prepared polyglycidyl methacrylate base ball, the particle diameter of the polyacrylate base ball is 15 μm~25 μm and the pore diameter is Use concentrated sulfuric acid to prepare 0.45M concentrated sulfuric acid solution for acidic activation treatment, and add polyacrylate base balls to the concentrated sulfuric acid solution and stir to activate the base balls. The stirring speed is 300rpm, and the activation time is 80min to obtain activated polyacrylate microspheres. ball;

[0059] Secondly, carry out the first bonding reaction to the obtained activated polyacrylate microspheres, disperse the microspheres in a 32% KOH alkaline solution, and add a 4.0% epichlorohydrin solution at a reaction temperature of 60°C , the reaction pressure is 0.12MPa, the reaction time is 20h for the first bonding reaction, the pH value is maintained at about 9.3, and th...

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Abstract

The invention provides a preparation method of sulfated polyacrylate emulsion, which comprises the following steps: activating polyacrylate-based spheres, carrying out two-time bonding reaction on the activated microspheres, and carrying out repeated cleaning and solution washing treatment to finally obtain the sulfated polyacrylate emulsion. According to the preparation method, reaction is carried out in a water phase system, the reaction temperature is mild, and the pressure is close to normal pressure, so that reaction condition control is easily realized; the sulfated polyacrylate emulsion obtained through the preparation method is uniform in particle size, the particle size ranges from 15 micrometers to 90 micrometers, the pore diameter is as follows: the sulfated polyacrylate emulsion has better hydrophilicity, non-specific adsorption with biological samples is avoided to the maximum extent, compared with other hydrophobic filler, the pore diameter is larger, and the hydrophobicity is better than that of other hydrophobic filler. The method is more suitable for separation and purification of biological samples with larger molecular weight; meanwhile, the preparation method is simple in process, and the used raw materials are easy to obtain, so that the production cost is low.

Description

technical field [0001] The invention relates to the technical field of preparation of sulfated polyacrylate emulsion materials for liquid chromatography media, in particular to a sulfated polyacrylate emulsion and a preparation method of the sulfated polyacrylate emulsion. Background technique [0002] Liquid phase adsorption chromatography separation technology is a high-efficiency physical separation technology, and its core component is a chromatographic separation column. The separation principle is: the mixed component sample is dissolved in a mobile phase, and the mobile phase flows through the chromatographic filler (filler) filled in the chromatographic separation column at a certain flow rate under the condition of relatively high pressure. The packing has different adsorption capacity for different components, so different components will flow through the chromatographic packing at different flow rates, and the time and content of the components will be detected in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/32C08F120/32C08F122/14C08F120/14C08F220/14C08F8/36C08F8/14
CPCC08F8/36C08F8/14C08F220/325C08F120/32C08F122/1006C08F120/14C08F220/14
Inventor 陈德君徐新东董成贺李庆卿王群行王辉
Owner 赛分科技扬州有限公司
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