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Polyacrylate-based ball and amine salt modification method thereof

A technology of polyacrylate and polyacrylate emulsion, which is applied in the field of amine salt modification of polyacrylate-based spheres and polyacrylate-based spheres, and can solve the problems affecting the separation and analysis of liquid chromatography media and particle size And the pore size structure can not be accurately controlled, the particle size and pore size are not uniform, etc., to avoid non-specific adsorption, the reaction conditions are easy to control, and the chemical reaction is fully complete.

Pending Publication Date: 2022-04-01
赛分科技扬州有限公司
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  • Summary
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  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The particle size and pore size structure of microsphere fillers prepared by traditional methods cannot be precisely controlled, and the particle size and pore size are not uniform, which limits its practical application in liquid chromatography to a large extent, and seriously affects its use as a liquid phase. Separation and analytical performance of chromatographic media

Method used

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  • Polyacrylate-based ball and amine salt modification method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The amine salt modification method of a polyacrylate-based ball provided in this embodiment mainly carries out the following treatment: first, the polyglycidyl methacrylate-based ball modified in advance with the amine salt is used, and the polyacrylate-based ball is The particle size is 15μm~25μm and the pore size is , use concentrated sulfuric acid to prepare 0.45M concentrated sulfuric acid solution for acid activation treatment, and add polyacrylate base balls to the concentrated sulfuric acid solution and stir evenly to activate the base balls, the stirring speed is 300rpm, and the activation time is 80min to obtain activated polyacrylate Microspheres;

[0041] Secondly, disperse the polyacrylate epoxy ester filter cake in the 53% dimethylamine salt hydrochloric acid solution modified by amine salt in advance, control the reaction temperature at 60°C, the reaction pressure at 0.18MPa, and the reaction time at 14h for bonding Reaction, make polyacrylate epoxy este...

Embodiment 2

[0046] The amine salt modification method of a polyacrylate-based ball provided in this embodiment mainly carries out the following treatment: first, the poly(ethylene glycol dimethacrylate)-based ball modified with amine salt in advance is used, and the polyacrylate The particle size of the base ball is 30μm~50μm and the pore size is Use concentrated sulfuric acid to make 0.35M concentrated sulfuric acid solution for acid activation treatment, and add polyacrylate base balls to the concentrated sulfuric acid solution and stir evenly to activate the base balls. The stirring speed is 350rpm and the activation time is 110min to obtain activated polyacrylate microspheres ball;

[0047] Secondly, disperse the polyacrylate epoxy ester filter cake in the pre-modified 48% triethylamine salt hydrochloric acid solution, control the reaction temperature at 65°C, the reaction pressure at 0.16MPa, and the reaction time at 18h for bonding Reaction, make polyacrylate epoxy ester filter ca...

Embodiment 3

[0052] The amine salt modification method of a polyacrylate-based ball provided in this embodiment mainly carries out the following treatment: first, the polyglycidyl methacrylate-polyethylene glycol dimethacrylate modified in advance is used Ester copolymer base ball, the particle size of the copolymer polyacrylate base ball is 45μm~60μm and the pore size is Use concentrated sulfuric acid to prepare 0.5M concentrated sulfuric acid solution for acidic activation treatment, and add copolymerized polyacrylate base balls to the concentrated sulfuric acid solution and stir evenly to activate the base balls. The stirring speed is 280rpm, and the activation time is 100min to obtain activated polyacrylate. Copolymerized microspheres;

[0053] Next, disperse the filter cake of copolymerized polyacrylic acid epoxy ester in 45% trimethylamine hydrochloric acid solution modified by amine salt in advance, control the reaction temperature to be 65°C, the reaction pressure to be 0.12MPa, a...

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Abstract

The invention provides an amine salt modification method for polyacrylate-based balls, which comprises the following steps: carrying out bonding reaction on activated polyacrylate-based balls, and carrying out repeated cleaning and solution washing treatment to finally obtain a polyacrylate emulsion. According to the amine salt modification method, the reaction is carried out in a water phase system, the reaction temperature is mild, the pressure is close to normal pressure, so that the reaction condition control is easily realized, the particle size of the obtained emulsion is 15-90 microns, the pore diameter is that the polyacrylate emulsion has better hydrophilicity, non-specific adsorption with biological samples is avoided to the greatest extent, and the application prospect is wide. Compared with other hydrophobic fillers, the hydrophobic filler has larger pore diameter and is more suitable for separation and purification of biological samples with larger molecular weight; meanwhile, the amine salt modification method is simple in process, and the used raw materials are easy to obtain, so that the production cost is relatively low.

Description

technical field [0001] The invention relates to the technical field of amine salt modification of polyacrylate-based ball materials for carriers, in particular to a polyacrylate-based ball and a method for modifying the polyacrylate-based ball with amine salt. Background technique [0002] Now liquid chromatography packing materials are widely used in the technical fields of drug development, material analysis and separation, among which high performance liquid chromatography (HPLC) is the most commonly used analysis and separation method, mainly used in chemical industry, food hygiene, drug detection, Environmental monitoring and many other fields. The liquid chromatography packing (namely liquid chromatography medium) is the key basis for the establishment and development of high performance liquid chromatography technology. Among liquid chromatography media, polyesters, polyamino acids, polyacrylates, etc. are commonly used liquid chromatography media materials. This typ...

Claims

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Application Information

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IPC IPC(8): C08J9/36C08L33/14C08L35/02B01J20/26B01J20/28B01J20/30
Inventor 陈德君徐新东董成贺陈峰王群行王辉
Owner 赛分科技扬州有限公司
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