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Amine salt type polyacrylate emulsion and preparation method thereof

A technology of polyacrylate emulsion and polyacrylate is applied in the preparation of amine salt type polyacrylate emulsion and the field of amine salt type polyacrylate emulsion. The size and pore structure cannot be precisely controlled, and the particle size and pore size are not uniform, so as to avoid non-specific adsorption, easy control of reaction conditions, and full and complete chemical reaction.

Pending Publication Date: 2022-03-08
赛分科技扬州有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The particle size and pore size structure of microsphere fillers prepared by traditional methods cannot be precisely controlled, and the particle size and pore size are not uniform, which limits its practical application in liquid chromatography to a large extent, and seriously affects its use as a liquid phase. Separation and analytical performance of chromatographic media

Method used

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  • Amine salt type polyacrylate emulsion and preparation method thereof

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preparation example Construction

[0029] The present invention provides a kind of preparation method of amine salt type polyacrylate emulsion, comprises the following main steps:

[0030] S1 polyacrylate activation treatment, the pre-prepared polyacrylate-based balls with fixed components, particle size and pore size are subjected to acidic activation treatment to obtain activated polyacrylate microspheres; the particle size of the polyacrylate-based balls 15μm~90μm and the pore size is The acidic activation treatment uses concentrated sulfuric acid to prepare a 0.3M-0.7M concentrated sulfuric acid solution, and the polyacrylate-based balls are added to the concentrated sulfuric acid solution and stirred evenly to activate the polyacrylate-based balls. The stirring speed is 250rpm-350rpm, and the activation time is 60min~120min;

[0031] S2 The first bonding reaction, disperse the activated polyacrylate microspheres in the alkaline solution, and add the alkylene oxide solution to carry out the first bonding ...

Embodiment 1

[0049] The preparation method of a kind of amine salt type polyacrylate emulsion provided in this embodiment, firstly, adopt the pre-prepared polyglycidyl methacrylate-polyethylene glycol dimethacrylate copolymer base ball, the copolymerization type polyacrylate The particle size of acrylate-based balls is 45μm~60μm and the pore size is Use concentrated sulfuric acid to prepare 0.5M concentrated sulfuric acid solution for acidic activation treatment, and add copolymerized polyacrylate base balls to the concentrated sulfuric acid solution and stir evenly to activate the base balls. The stirring speed is 280rpm, and the activation time is 100min to obtain activated polyacrylate. Copolymerized microspheres;

[0050] Secondly, carry out the bonding reaction for the first time to obtain the activated polyacrylate copolymerized microspheres, the copolymerized microspheres are dispersed in 30% NaOH alkaline solution, and add the epichlorohydrin solution of concentration 5.0%, at rea...

Embodiment 2

[0057] The preparation method of an amine salt-type polyacrylate emulsion provided in this example, firstly, the pre-prepared polyglycidyl methacrylate-based balls are used, the polyacrylate-based balls have a particle size of 15 μm to 25 μm and a pore size for , use concentrated sulfuric acid to prepare 0.45M concentrated sulfuric acid solution for acid activation treatment, and add polyacrylate base balls to the concentrated sulfuric acid solution and stir evenly to activate the base balls, the stirring speed is 300rpm, and the activation time is 80min to obtain activated polyacrylate Microspheres;

[0058] Secondly, carry out the first bonding reaction to the obtained activated polyacrylate microspheres, disperse the microspheres in a 32% KOH alkaline solution, and add a 5.3% epichlorohydrin solution at a reaction temperature of 60°C , the reaction pressure is 0.12MPa, and the reaction time is 20h to carry out the first bonding reaction to obtain a polyacrylate epoxy este...

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Abstract

The invention provides a preparation method of an amine salt type polyacrylate emulsion, which comprises the following steps: activating polyacrylate-based spheres, carrying out two-time bonding reaction on the activated microspheres, and carrying out repeated cleaning and solution washing treatment to finally obtain the amine salt type polyacrylate emulsion. According to the preparation method, reaction is carried out in a water phase system, the reaction temperature is mild, and the pressure is close to normal pressure, so that reaction condition control is easily realized; the amine salt type polyacrylate emulsion obtained by the preparation method is uniform in particle size, the particle size is 15-90 [mu] m, the pore size is that the amine salt type polyacrylate emulsion has better hydrophilicity, non-specific adsorption with biological samples is avoided to the greatest extent, compared with other hydrophobic fillers, the pore size is larger, and the hydrophobic filler has better hydrophobic property. The method is more suitable for separation and purification of biological samples with larger molecular weight; meanwhile, the preparation method is simple in process, and the used raw materials are easy to obtain, so that the production cost is low.

Description

technical field [0001] The invention relates to the technical field of preparation of amine salt type polyacrylate emulsion materials for liquid chromatography media, in particular to an amine salt type polyacrylate emulsion and a preparation method of the amine salt type polyacrylate emulsion. Background technique [0002] Now liquid chromatography packing materials are widely used in the technical fields of drug development, material analysis and separation, among which high performance liquid chromatography (HPLC) is the most commonly used analysis and separation method, mainly used in chemical industry, food hygiene, drug detection, Environmental monitoring and many other fields. The liquid chromatography packing (namely liquid chromatography medium) is the key basis for the establishment and development of high performance liquid chromatography technology. Among liquid chromatography media, polyesters, polyamino acids, polyacrylates, etc. are commonly used liquid chrom...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/05C08L33/14C08L35/02
CPCC08J3/05C08J2333/14C08J2335/02
Inventor 陈德君徐新东董成贺李庆卿王群行王辉
Owner 赛分科技扬州有限公司
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