35results about How to "The reaction process is safe and controllable" patented technology

The invention provides a double-ring-fused aldehyde compound as well as a preparation method and application thereof. The molecular structure formula of the double-ring-fused aldehyde compound is shown in formula (I) in the description. The double-ring-fused aldehyde compound comprises four double-ring-fused structures: 5 / 5, 5 / 6, 5 / 7 and 6 / 6; the structure can be adjusted and modified, so that thestability of the ring-fused aldehyde compound in an acidic condition is improved; the probability of preparing into a medicine can be improved.

The invention discloses a method for effectively synthesizing a nitrile compound by reacting a copper salt, a ligand and a co-catalyst, a final oxidant such as with ammonia water under the mild condition in an alcohol and synthesizing multiple heterocyclic compounds with a one-pot method. In the method, the substrate adaptability is wide, the reaction time is short, the yield is high and the atom economy is high. Use of severe conditions, such as high temperature and high pressure and toxic starting materials is avoided; and the preparation method is simple in operation steps and less in corrosion on instruments, generates less waste gas, waste water and industrial residue, and is beneficial to further popularization and application, and industrial production.

The invention discloses a new green method for synthesizing sodium tanshinone IIA sulfonate. In the presence of a catalyst, safe, stable and inexpensive sodium bisulfate is used to directly sulfonate tanshinone IIA to obtain sodium tanshinone IIA sulfonate. Compared with the existing method, the method can obtain the target product through one-step reaction, and avoids the use of sulfonating reagents such as strong corrosive concentrated sulfuric acid and pyridine sulfur trioxide, as well as a large amount of saturated saline and sodium carbonate required for subsequent salt formation. The advantages of simple and efficient production process and recyclable reagents not only significantly reduce the production cost of sodium tanshinone IIA sulfonate, but also greatly alleviate the pressure of environmental pollution, and have great industrial production value.

The invention discloses an α-tetrasubstituted chiral acetylene compound, a preparation method and application thereof. The general molecular structure formula of the α-tetrasubstituted chiral ynone compound of the present invention is described in the general formula (I) in the description. The preparation method of the α-tetrasubstituted chiral ynone compound comprises the steps of adding the diacetylene enamine compound A into a reaction system containing a functional group reagent B, a chiral phosphoric acid catalyst and an alkaline reagent for reaction. The α-tetrasubstituted chiral acetylenone compound of the present invention can obtain a large number of chiral compounds with special ring structures through simple chemical transformation, and is widely used in the preparation of pharmaceutical intermediates. Its preparation method has simple process, low requirements on reaction conditions, safe and controllable reaction process, high atom utilization rate and production efficiency, and at the same time efficiently guarantees the enantioselectivity of the product, and the introduction of the concept of asymmetric catalysis of organic small molecules makes the method The environmental pollution pressure of the school is small.