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Preparation process of glucosamine sulfate

A technology of glucosamine sulfate and glucosamine hydrochloride, which is applied in the field of preparation of glucosamine sulfate, can solve the problems of stimulating angiotensin source and raising blood pressure, so as to avoid impurity removal process, reduce severity and controllable reaction process Effect

Inactive Publication Date: 2021-04-20
SHANDONG RUNDE BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Studies have shown that chloride ions stimulate the activity of angiotensin sources, leading to an increase in blood pressure
However, due to the preparation process, the existing glucosamine sulfate often contains more chloride ions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A preparation process for glucosamine sulfate, comprising the steps of:

[0025] (1) Mix glucosamine hydrochloride (sodium salt) and absolute ethanol according to the ratio of 1g: 15mL, and then ultrasonically stir for 30min to fully disperse glucosamine hydrochloride in absolute ethanol to obtain glucosamine hydrochloride Salt suspension, set aside.

[0026] (2) According to the ratio of 1:1 molar ratio of glucosamine hydrochloride and sodium hydroxide, gradually add sodium hydroxide powder in the suspension of said glucosamine hydrochloride to neutralize excess acid, then slowly mechanically stir, During the reaction process, the pH value of the system is monitored at any time, and the reaction is completed when the reaction system reaches neutrality.

[0027] (3) After the neutralization reaction of step (2) is completed, according to the ratio of chloride ion and silver ion molar ratio being 1:1, silver sulfate solution is dripped in reaction system, and leave stan...

Embodiment 2

[0030] A preparation process for glucosamine sulfate, comprising the steps of:

[0031] (1) Mix glucosamine hydrochloride (sodium salt) with anhydrous methanol according to the ratio of 1g: 20mL, and then ultrasonically stir for 30min to fully disperse glucosamine hydrochloride in anhydrous methanol to obtain glucosamine hydrochloride Salt suspension, set aside.

[0032] (2) According to the ratio of 1:1 molar ratio of glucosamine hydrochloride and sodium hydroxide, gradually add sodium hydroxide powder in the suspension of said glucosamine hydrochloride to neutralize excess acid, then slowly mechanically stir, During the reaction process, the pH value of the system is monitored at any time, and the reaction is completed when the reaction system reaches neutrality.

[0033] (3) After the neutralization reaction of step (2) is completed, according to the ratio of chloride ion and silver ion molar ratio being 1:1, silver sulfate solution is dripped in reaction system, and leave...

Embodiment 3

[0036] A preparation process for glucosamine sulfate, comprising the steps of:

[0037] (1) Mix glucosamine hydrochloride (potassium salt) and propanol according to the ratio of 1g: 20mL, then ultrasonically stir for 30min, so that glucosamine hydrochloride is fully dispersed in propanol, and obtain the glucosamine hydrochloride Suspension, set aside.

[0038] (2) According to the ratio of glucosamine hydrochloride and potassium hydroxide molar ratio 1:1, in the suspension of described glucosamine hydrochloride, gradually add potassium hydroxide powder to neutralize excess acid, then slowly mechanically stir, During the reaction process, the pH value of the system is monitored at any time, and the reaction is completed when the reaction system reaches neutrality.

[0039] (3) After the neutralization reaction of step (2) is completed, according to the ratio of chloride ion and silver ion molar ratio being 1:1, silver sulfate solution is dripped in reaction system, and leave s...

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Abstract

The invention relates to a preparation process of glucosamine sulfate. The preparation process comprises the following steps of (1) uniformly stirring glucosamine hydrochloride and monohydric alcohol to obtain an alcoholic solution of glucosamine hydrochloride for later use; (2) adding an alkaline neutralizer into the alcoholic solution, adding a silver sulfate solution after the reaction is finished, stirring, standing, and carrying out solid-liquid separation on the reaction system; and (3) adjusting the liquid separated in the step (2) to be acidic, then distilling to obtain glucosamine sulfate, and recovering the distilled solvent. Silver sulfate is adopted to fix chloride ions in glucosamine hydrochloride in a monohydric alcohol system in a silver precipitation mode; compared with traditional adsorption, extraction and other methods, the method is efficient and rapid, more importantly, the chloride ions in glucosamine hydrochloride can be thoroughly removed; and the obtained silver precipitate is easy to separate and recover and can be used as an industrial by-product, and no extra solid waste is generated.

Description

technical field [0001] The invention relates to the technical field of preparation of glucosamine, in particular to a preparation process of glucosamine sulfate. Background technique [0002] The following content in the background technology only refers to the information related to the present invention understood by the inventor, and aims to increase the understanding of the present invention by explaining some basic technical knowledge related to the present invention. Knowledge known to those of ordinary skill in the art. [0003] Since glucosamine (molecular formula C 6 h 13 NO 5 ) are easily oxidized and cannot be stored stably at room temperature. Currently commercialized glucosamine mainly exists in the form of glucosamine hydrochloride and glucosamine sulfate to prevent the amino groups in glucosamine from being oxidized. And glucosamine sulfate (molecular formula C 6 h 13 NO 8 S) is an important component necessary for the synthesis of proteoglycans in the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H11/00C07H1/06C07H1/00C07H5/06
Inventor 卢健行尹训娟张建华姚珊珊水清洋
Owner SHANDONG RUNDE BIOTECH CO LTD
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