The invention provides a bridge aseismic design method based on a response surface model, it can fully consider different bridge types and corresponding design parameters as well as ground motion intensity, by establishing the response surface model of bridge seismic failure probability, the adjustment range of each parameter of the bridge is obtained,when performance requirements are not met, facilitating the determination of the direction and scope of the adjustment, the tuning process is more intuitive through the model, thus, the optimum value of each design parameter of the bridge can beobtained quickly and conveniently, the design capacity of the bridge can be optimized, the safety coefficient of the bridge can be improved, the service life can be prolonged, the practicability is strong, the calculation process is simple, the design time cost is greatly reduced, the design efficiency can be improved under the condition of meeting the seismic demand of the bridge, and the bridgehas excellent application prospect.