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Adjuvant-containing methylprednisolone aceponate separation type water suspension agent drug for treating skin diseases

A technology for methylprednisolone acetonide and dermatology, which is applied to skin diseases, drug combinations, pharmaceutical formulations, etc., can solve the problems of unstable particles, inability to guarantee the Ostwald ripening of the particle suspension, and reduce waste. , easy to use effect

Inactive Publication Date: 2012-07-11
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] How to solve the problem of particle instability in microparticle suspensions has always been one of the problems that need to be solved in pharmacy, but no matter by adding excipients or improving the particle structure, there is no guarantee that microparticle suspensions will not appear Ostwald particles. Aging phenomena, especially skin suspensions that are used repeatedly, are more likely to have the above problems

Method used

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  • Adjuvant-containing methylprednisolone aceponate separation type water suspension agent drug for treating skin diseases
  • Adjuvant-containing methylprednisolone aceponate separation type water suspension agent drug for treating skin diseases

Examples

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preparation example Construction

[0030] 1. Preparation of drug particles for transdermal absorption

[0031] The capsules packed with the drug microparticles obtained in Examples 1 to 10 are vegetable capsules, and the capsules are sealed and packaged in glass bottles after packing.

Embodiment 1

[0033] Dissolve 0.2g methylprednisolone acetate in ethanol, filter, sterilize, spray-dry the filtrate, and micronize to make the particle size reach 3μm, with 1g sodium lauroyl sarcosinate and 1.5g crystalline lactose with a particle size of 30μm After mixing, pass through a 200-mesh sieve for 3 times and mix evenly, then pack in No. 2 capsules, each capsule contains 2 mg of methylprednisolone acetate. Electron microscope observation shows that the drug particles are spherical.

[0034] The process conditions are: the inlet temperature is 100°C, the outlet temperature is 70°C, the air flow rate is 90%, the inner diameter of the nozzle outlet is 0.1cm, the air flow rate of the nozzle is 800ml / min, and the injection speed is 50mL / h

Embodiment 2

[0036] Dissolve 1 g of methylprednisolone acetate in ethanol, filter, spray-dry the filtrate, and micronize the particle size to 3 μm, mix it with 12 g of sodium lauroyl glutamate and 15 g of crystalline lactose with a particle size of 30 μm, and use 200 mesh Sieve 3 times, mix evenly, sterilize, and pack into No. 2 capsules. Each capsule contains 1 mg of methylprednisolone acetate. Electron microscope observation shows that the particles are spherical.

[0037] The process conditions are as follows: inlet temperature is 105°C, outlet temperature is 70°C, air flow rate is 90%, nozzle outlet inner diameter is 0.1cm, nozzle air flow rate is 800ml / min, and sample injection speed is 50mL / h.

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Abstract

The invention relates to an adjuvant-containing methylprednisolone aceponate separation type water suspension agent drug for treating skin diseases. The drug comprises methylprednisolone aceponate and water, wherein the packing manner of the methylprednisolone aceponate adopts the individual packing, the methylprednisolone aceponate contains one or a plurality of skin medicine adjuvants, and is insoluble, the D90 particle size is 0.1-10 mum, and the packing manner of the water adopts the individual packing.

Description

Technical field: [0001] The invention relates to a dermatological medicine, which is composed of methylprednisolone acetone and separately packaged water, which contain one or several dermatological auxiliary materials. Background technique: [0002] Skin inflammations such as eczema, allergic dermatitis, atopic dermatitis, and urticaria are caused by allergic reactions caused by certain allergens. [0003] In the skin drug delivery system, the skin is the main barrier for drugs to enter the body. Studies have found that only a few drugs have excellent skin permeability, and most drugs are not easy to pass through the effective and selective barrier of human skin. Drugs with higher solubility cross the epidermis more easily. In the treatment of skin diseases, the most common type of preparation is transdermal drug delivery, transdermal drug delivery system or transdermal drug delivery system (transdermal thrapeutic systems, transdermal drug delivery systems, referred to as ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/573A61P17/00A61P17/08A61P37/08
Inventor 孙亮陈松赵琳
Owner TIANJIN JINYAO GRP
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