Application of lucide ganoderma and ginseng medicinal mycoplasm in preparing drugs for treating lung cancer

A technology of medicinal fungus and ginseng, applied in the field of bioengineering

Inactive Publication Date: 2012-08-01
邱智东 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is currently no document disclosing the application of Ganoderma lucidum and ginseng medicinal bacteria in the treatment of tumors, especially in the treatment of lung cancer.

Method used

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  • Application of lucide ganoderma and ginseng medicinal mycoplasm in preparing drugs for treating lung cancer
  • Application of lucide ganoderma and ginseng medicinal mycoplasm in preparing drugs for treating lung cancer
  • Application of lucide ganoderma and ginseng medicinal mycoplasm in preparing drugs for treating lung cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Inoculate the Ganoderma lucidum strain preserved by the Institute of Medicinal Fungi, Changchun University of Traditional Chinese Medicine, on a PDA slant medium, and cultivate it at 27°C ± 1°C, and cultivate it for 7 days to obtain mycelium for use;

[0018] Production containing 2wt% glucose, 0.5wt% peptone, 0.1wt% yeast powder, 0.15wt% KH 2 PO 4 , and 0.1wt% MgSO 4 culture medium of bacteria. Take 100mL of strain culture solution into a 250mL Erlenmeyer flask, and sterilize at 0.1MPa and 121°C for 30min. Cut 4 pieces of 0.5cm×0.5cm mycelium into the strain culture solution of the Erlenmeyer flask in a sterile room, and vibrate and culture for 5 days under the conditions of 28°C and 150r / min to obtain a seed solution containing mycelium balls;

[0019] Take 50g of sun-dried ginseng without insects and mildew, crush it through a 60-mesh sieve, add 50g of water to moisten it for 12 hours, put the obtained ginseng into a 500mL triangular flask, sterilize it at 0.1MPa ...

Embodiment 2

[0022] Inhibitory effect of Ganoderma lucidum and ginseng medicinal mycoplasma on Lewis lung cancer in mice

[0023] 2.1 Experimental materials

[0024] 2.1.1 Experimental animals and grouping

[0025] Female C57BL / 6 mice were purchased from the Shrek Animal Center, Shanghai Branch of the Chinese Academy of Sciences, and were randomly divided into 7 groups according to body weight:

[0026] A is the blank group, B is the model group, C is the positive drug cisplatin group, D is the Shenyi capsule group, E is the low-dose group of Ganoderma lucidum and ginseng medicinal bacteria (0.5g / kg), F is the medicinal fungus of Ganoderma ginseng Dosage group (1g / kg), G is the high-dose group (2g / kg) of ganoderma ginseng medicinal mycoplasma, H is the ginseng group (2g / kg), I is the ganoderma group (2g / kg), J is the ginseng group ( 2g / kg);

[0027] There were 12 rats in each group, and each group was divided into 2 cages, with 6 rats in each cage.

[0028] 2.1.2 Experimental reagents ...

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Abstract

The invention provides an application of lucide ganoderma and ginseng medicinal mycoplasm in preparing drugs for treating lung cancer, wherein the lucide ganoderma and ginseng medicinal mycoplasm takes ginseng as a base material and lucide ganoderma as a strain, is obtained after bidirectional solid fermentation, contains ginsenosides Rg1, Rb1, Re, Rg3, Rh1 and various ginsenosides, as well as ginseng polysugar, ganoderan and other ingredients, and can be used for producing drugs for treating lung cancer. According to the invention, the lucide ganoderma and ginseng medicinal mycoplasm is taken as an internal treatment drug for carrying out research on a mice Lewis with lung cancer, is respectively used for the intragastric administration of the mice at the dosages of 0.5g/kg, 1.0k/kg and 2.0g/kg, meanwhile, a blank group, a model group, a cisplatin group, a Shenyi capsule group, a ginseng group, a lucide ganoderma group and a ginseng and lucide ganoderma group are taken for comparison, results show that: the lucide ganoderma and ginseng medicinal mycoplasm has the equivalent treatment effect on lung cancer as cisplatin, Shenyi capsules and other drugs, and is better than the lucide ganoderma, ginseng and the ginseng plus the lucide ganoderma.

Description

technical field [0001] The invention relates to the technical field of bioengineering, in particular to the application of ganoderma lucidum and ginseng medicinal bacteria in the preparation of medicines for treating lung cancer. Background technique [0002] Lung cancer is the most common primary malignant tumor of the lung. The vast majority of lung cancers originate from the bronchial mucosal epithelium, so it is also called bronchial lung cancer. Over the past 50 years, the incidence and mortality of lung cancer have risen rapidly in countries all over the world, especially in industrially developed countries. Lung cancer has ranked first among male patients who died of cancer. Therefore, effective treatment of lung cancer is one of the current research hotspots. [0003] At present, the prior art discloses a variety of drugs for the treatment of lung cancer, such as cisplatin found by B. Rosenborg. Cisplatin is a commonly used chemical drug for cancer treatment. All k...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K36/074A61P35/00
CPCA61K36/074A61K36/258A61P35/00A61K2300/00
Inventor 邱智东隋殿军陈心智
Owner 邱智东
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