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Lactobacillus plantarum P8 capable of regulating short-chain fatty acid and total bile acid metabolism in human intestinal tract as well as detection method

A technology of medium and short-chain fatty acids and total bile acids, applied in the field of probiotics, can solve problems such as increasing the risk of gallstones, colon cancer, and human harm

Inactive Publication Date: 2012-08-01
北京和美科盛生物技术有限公司
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Problems solved by technology

In some cases, DCA accumulates in blood, bile, and feces, which increases the risk of gallstones and colon cancer, and secondary bile acids are promoters of malignancies and are harmful to the human body

Method used

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  • Lactobacillus plantarum P8 capable of regulating short-chain fatty acid and total bile acid metabolism in human intestinal tract as well as detection method
  • Lactobacillus plantarum P8 capable of regulating short-chain fatty acid and total bile acid metabolism in human intestinal tract as well as detection method

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Embodiment Construction

[0037] A probiotic strain that regulates the metabolism of short-chain fatty acids and total bile acids in the human intestine. The probiotic (Lactobacillus plantarum P8) is isolated from the yogurt handmade by herders in Inner Mongolia and preserved in the Common Microbial Cultures of China Microbiological Culture Collection Management Committee Deposit Center, deposit number: CGMCC No.5468, deposit date: November 18, 2011.

[0038] A method for detecting probiotics that regulate the metabolism of short-chain fatty acids and total bile acids in the human intestine, comprising the following steps:

[0039] 1. Determination of Short Chain Fatty Acids

[0040] 1.1 Collection of test samples

[0041] A total of 33 healthy volunteers were recruited in this experiment, divided into three groups, the youth group (Y group, 11 people, 5 males, 6 females), aged 25-29 years, with an average age of 26.2±1.2 years; the middle-aged group (M group, 12 people, 6 males, 6 females), aged 48-...

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Abstract

The invention relates to Lactobacillus plantarum P8 capable of regulating short-chain fatty acid and total bile acid metabolism in a human intestinal tract. The Lactobacillus plantarum P8 is separated from yoghourt made by hand by Inner Mongolia shepherds and is collected in the China General Microbiological Culture Collection Center of China Committee for Culture Collection of Microorganisms on November 18, 2011, with the collection number being CGMCC No.5468. The invention additionally discloses a detection method of the Lactobacillus plantarum P8.

Description

technical field [0001] The invention relates to a probiotic strain that can regulate the metabolism of short-chain fatty acids (SCFA) and total bile acids (TBA) in human intestines. The application of high-performance liquid chromatography (HPLC) technology found that taking the strain daily can promote the metabolism of short-chain fatty acids in the intestine, and the application of enzyme-linked immunoassay (ELISA) technology detection found that taking the strain daily can inhibit the total bile in the intestine Metabolism of acid, so as to achieve the effect of regulating the balance of intestinal flora, improving intestinal function and regulating gene expression. Background technique [0002] There are more than 1,000 microorganisms with a total number of more than one trillion living in the human intestine. The chemical substances produced by these microorganisms will affect the balance of intestinal flora, intestinal function and immune mechanism of the human body. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/20G01N30/88G01N33/543C12R1/25
Inventor 张佳超
Owner 北京和美科盛生物技术有限公司
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