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Application of Picria fel-terrae Lour extract in pharmacy

A technology of bitter scrophulariae and extract, which is applied in the application field of bitter scrophulariae extract in pharmaceuticals, and can solve the problems such as no pain relief drugs of bitter scrophulariae extract

Inactive Publication Date: 2012-08-22
GUANGXI INST OF BOTANY THE CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no public report on the use of bitter scrophulariae extract for the preparation of analgesic drugs

Method used

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  • Application of Picria fel-terrae Lour extract in pharmacy
  • Application of Picria fel-terrae Lour extract in pharmacy
  • Application of Picria fel-terrae Lour extract in pharmacy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] 1) Preparation: take the dried bitter scrophulariaceae, crush it to 100 mesh, and set aside;

[0019] 2) Extraction: Weigh 5 kg of crushed medicinal materials, add water to decoct and extract three times (the amount of water added is 8 times, 6 times, and 4 times the weight of the medicinal materials, and the extraction time is 2 hours, 1.5 hours, and 1.5 hours respectively), and combined Medicinal solution, 80.0L of extract was obtained; 10.0L of the extract was concentrated, dried in vacuum, and 66.2g of Sophora scrophulariae extract A was obtained;

[0020] 3) Ultrafiltration: The remaining extract is ultrafiltered with an ultrafiltration membrane with a molecular weight cut-off of 10,000, and the ultrafiltration permeate is collected for subsequent use; at the same time, the ultrafiltration retentate is concentrated and vacuum-dried to obtain the bitter scrophulariaceae extract B676. 8g;

[0021] 4) Adsorption and separation of macroporous resin column: Ultrafiltra...

Embodiment 2

[0023] 1) Preparation: take the dried bitter scrophulariaceae, crush it to 80 mesh, and set aside;

[0024] 2) Extraction: Weigh 5 kg of crushed medicinal materials, add water to decoct and extract twice (the amount of water added is 8 times and 6 times the weight of the medicinal materials respectively, and the extraction time is 2 hours and 1.5 hours respectively), and the medicinal liquid is combined to obtain the extracted liquid 60.0L; get wherein 10.0L extract concentrated, vacuum-dried to obtain bitter crocus extract A 65.7g;

[0025] 3) Ultrafiltration: The remaining extract is ultrafiltered with an ultrafiltration membrane with a molecular weight cut-off of 8000, and the ultrafiltration permeate is collected for subsequent use; at the same time, the ultrafiltration retentate is concentrated and vacuum-dried to obtain the bitter scrophulariaceae extract B674. 1g;

[0026] 4) Adsorption and separation of macroporous resin column: the ultrafiltration permeate is passed ...

Embodiment 3

[0028] 1) Preparation: take the dried bitter scrophulariaceae, crush it to 160 mesh, and set aside;

[0029] 2) Extraction: Weigh 5 kg of crushed medicinal materials, add water to decoct and extract twice (the amount of water added is 8 times and 5 times the weight of the medicinal materials respectively, and the extraction time is 2 hours and 2.0 hours respectively), and the medicinal liquid is combined to obtain the extract 58.0L; 10.0L of the extract was taken to concentrate and vacuum-dried to obtain 64.1g of Sophora scrophulariae extract A;

[0030] 3) Ultrafiltration: The remaining extract is ultrafiltered with an ultrafiltration membrane with a molecular weight cut-off of 5000, and the ultrafiltration permeate is collected for subsequent use; at the same time, the ultrafiltration retentate is concentrated and vacuum-dried to obtain the bitter scrophulariaceae extract B661. 8g;

[0031] 4) Adsorption and separation of macroporous resin column: ultrafiltration permeate t...

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Abstract

The invention discloses application of a Picria fel-terrae Lour extract in pharmacy, in particular to application of the Picria fel-terrae Lour extract in analgesic drugs. The preparation method of the Picria fel-terrae Lour extract comprises the following steps of: taking Picria fel-terrae Lour, adding water, decocting and extracting, the resulting extract passing through a macroporous resin column, washing the resin column with water, and then eluting with lower carbon alcohol with a volume concentration of 40 to 50, collecting an alcohol eluate, concentrating and drying to obtain the Picria fel-terrae Lour extract. The applicant found that the analgesic inhibition rate of the extract with the same dosage is almost 2 times larger than that of a Picria fel-terrae Lour aqueous extract, the anti-inflammatory effect is better while the analgesic effect is ensured, and the extract has little toxic side effects and is very suitable for the preparation of analgesic drugs.

Description

technical field [0001] The invention relates to the field of medical application of plant extracts, in particular to the application of bitter crocus extracts in pharmacy. Background technique [0002] Bitter Scrophulariaceae (Picria Felterrae Lour), also known as bitter grass, bear bile grass, tetracycline grass, is a perennial herbaceous plant of the family Bitterraeaceae, mainly produced in Guangxi and Guangdong. The whole herb can be used as medicine, and it has a long history of being used in the treatment of inflammations such as pneumonia, colds, pharyngitis, bruises, and lymphadenitis among the people. [0003] Many scholars have conducted systematic research on the compounds in Scrophularia scrophulariae, from which compounds such as triterpenoids, flavonoids and phenylethanol glycosides have been isolated. Existing pharmacological and clinical results have shown that Scrophulariae sophora has broad-spectrum antibacterial, anti-inflammatory and antiviral effects, n...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/80A61P29/00
Inventor 陈月圆黄永林文永新李典鹏吴建璋卢凤来
Owner GUANGXI INST OF BOTANY THE CHINESE ACAD OF SCI
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