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Production method of p-trifluoromethylaniline

A technology of trifluoromethylaniline and p-chlorobenzotrifluoride, which is applied in the field of production of p-trifluoromethylaniline, and can solve the problems of large pollution and low single-pass conversion rate

Inactive Publication Date: 2012-08-22
江苏优普生物化学科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The existing production method of p-trifluoromethylaniline has a low conversion rate per pass, generally only within 40%, and the pollution is large

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] A kind of production method of p-trifluoromethylaniline, with p-chlorobenzotrifluoride and liquid ammonia under the condition that alcohol and catalyst exist, react in autoclave, the consumption of p-chlorobenzotrifluoride, liquid ammonia, alcohol, catalyst They are: p-chlorobenzotrifluoride 950kg, liquid ammonia 450kg, alcohol 800kg, catalyst 180kg, the reaction temperature is 150-230°C, the pressure is 6-16Mpa, and the reaction time is 9-13 hours. After the reaction is over, the excessive liquid ammonia is absorbed into ammonia water, and industrial alcohol is flashed out simultaneously, and the catalyst is removed by filtration, and the catalyst regeneration is applied mechanically. 90%, the above catalyst is composed of the following components by weight percentage:

[0015] Cuprous chloride: 40%

[0016] Potassium fluoride: 60%.

Embodiment 2

[0018] A kind of production method of p-trifluoromethylaniline: p-chlorobenzotrifluoride and liquefied ammonia are reacted in an autoclave in the presence of alcohol and catalyst, and the consumption of p-chlorobenzotrifluoride, liquid ammonia, alcohol and catalyst They are: 900kg of p-chlorobenzotrifluoride, 400kg of liquid ammonia, 700kg of alcohol, 160kg of catalyst, the reaction temperature is 140-230°C, the pressure is 6-17Mpa, and the reaction time is 9-13 hours. After the reaction is over, the excess liquid ammonia is absorbed into ammonia water, and industrial alcohol is flashed off at the same time, and the catalyst is removed by filtration. The catalyst can be recycled and used. The obtained p-trifluoromethylaniline crude product is rectified to obtain a finished product with a yield of about 90%. Above-mentioned catalyst is made up of the composition of following weight percent:

[0019] Cuprous chloride: 30%

[0020] Potassium fluoride: 70%.

Embodiment 3

[0022] A kind of production method of p-trifluoromethylaniline: p-chlorobenzotrifluoride and liquefied ammonia are reacted in an autoclave in the presence of alcohol and catalyst, and the consumption of p-chlorobenzotrifluoride, liquid ammonia, alcohol and catalyst They are: p-chlorobenzotrifluoride 1000kg, liquid ammonia 600kg, alcohol 900kg, catalyst 189kg, the reaction temperature is 140-230°C, the pressure is 6-17Mpa, and the reaction time is 9-13 hours. After the reaction, the excess liquid ammonia is absorbed into ammonia water, and industrial alcohol is flashed off at the same time, and the catalyst is removed by filtration. The catalyst can be recycled and used. The crude product of p-trifluoromethylaniline is rectified to obtain the finished product with a yield of about 90%. Above-mentioned catalyst is made up of following weight components:

[0023] Cuprous Chloride 50%

[0024] Potassium Fluoride 50%.

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PUM

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Abstract

The invention discloses a production method of p-trifluoromethylaniline. The production method comprises the following step: enabling p-chlorobenzotrifluoride and liquid ammonia to react in the presence of alcohol and a catalyst to get the p-trifluoromethylaniline, wherein the catalyst mainly comprises cuprous chloride and potassium fluoride. According to the production method disclosed by the invention, the high-efficient compound catalyst is adopted, and the yield can achieve 90%; and an organic solvent in the production method can be applied mechanically in a circulating manner, no wastewater exists, the excess liquid ammonia can be produced into ammonia water for selling, and the catalyst can be recycled.

Description

technical field [0001] The present invention relates to a kind of production method of p-trifluoromethylaniline. Background technique [0002] The existing production method of p-trifluoromethylaniline has a low conversion rate per pass, generally only within 40%, and the pollution is large. Contents of the invention [0003] The object of the present invention is to provide a kind of single pass conversion rate height, the production method of the high p-trifluoromethylaniline of yield. [0004] Technical solution of the present invention is: [0005] A production method of p-trifluoromethylaniline is characterized in that: p-chlorobenzotrifluoride and liquid ammonia are reacted to obtain p-trifluoromethylaniline in the presence of alcohol and a catalyst; wherein the catalyst is mainly composed of the following weight Component composition in percent: [0006] Cuprous chloride: 30~60% [0007] Potassium fluoride: 40-70%. [0008] The consumption ratio of p-chlorobe...

Claims

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Application Information

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IPC IPC(8): C07C211/52C07C209/10B01J27/122
CPCY02P20/584
Inventor 陶坤山徐国军于海军张建华
Owner 江苏优普生物化学科技股份有限公司
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