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Gamuzhuer medicinal latex preparation and preparation method thereof

A Gamuzhuer emulsion technology, applied in the field of Gamujuer emulsion and its preparation, can solve the problems of high irritation of anionic emulsifiers, difficulty in forming suppositories, and strong irritation of alcohol, etc., so as to accelerate the onset of effect time, administration convenience, and the effect of prolonging the action time

Inactive Publication Date: 2013-09-25
SHENZHEN JIAXUAN MEDICAL TECH DEV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There are also studies to make it into suppositories to facilitate its gynecological application, but because the compound contains minerals and the dosage is large, the forming of the suppositories is difficult and difficult to prepare
Chinese patent 200610112027.5 relates to a Mongolian medicine for treating gynecological inflammation. During the preparation process, alcohol is used to extract the active ingredients of traditional Chinese medicine, and the residual alcohol is also highly irritating; and sodium lauryl sulfate is used as an emulsifier during preparation, and anion Emulsifiers are also more irritating

Method used

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  • Gamuzhuer medicinal latex preparation and preparation method thereof
  • Gamuzhuer medicinal latex preparation and preparation method thereof
  • Gamuzhuer medicinal latex preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] According to the Pharmacopoeia of Mongolian Medicine, cold water stone, realgar, cassia, cinnabar, silver beads, musk, and borneol were weighed in proportion, ground into fine powder, passed through an 80-mesh primary sieve, and jet crushed to obtain the required micronized main drug.

[0035] Said Gamuzhuer is composed of 7 medicinal herbs of Hanshuishi, realgar, cinnabar, silver vermilion, stone cassia, borneol and musk, and the parts by weight of each component are:

[0036] 35 parts of cold water stone, 10 parts of realgar, 5 parts of cinnabar, 5 parts of vermilion, 5 parts of cassia, 25 parts of borneol, 0.5 part of musk;

[0037] The powder particle size was measured by laser diffraction method, and the specific particle size distribution is shown in the table below.

[0038] sample

Embodiment 2

[0040] (1) Gamujuer 97.5g and 150g glycerin, 10g Tween 80 of Example 1 are weighed and mixed uniformly;

[0041] (2) Take 2.5 g of the bioadhesive agent sodium alginate to swell with 64 g of water, add step (1) Gamujuer, and mix well;

[0042] (3) Take 30g of stearyl alcohol, 20g of white petrolatum, 20g of glyceryl monostearate, 30g of liquid paraffin, 20g of lanolin, and 30g of simethicone, mix and heat to 60°C; add 5g of Span 80 and 5g of Tween 80 and 16g water, stir, let cool to get emulsion;

[0043] (4) Mix the mixture of step (2) and the emulsion of step (3) evenly, the total weight is 500g, pack separately, and obtain.

Embodiment 3

[0045] (1) Gamujuer 200g and 100g glycerin, 10g Tween 80 of Example 1 are weighed and mixed uniformly;

[0046] (2) Take 0.25 g of bioadhesive sodium carboxymethyl cellulose to swell with 25 g of water, add step (1) Gamujuer and mix;

[0047] (3) Take 30g of white petrolatum, 20g of glyceryl monostearate, 30g of liquid paraffin, and 20g of simethicone, mix and heat to 50°C; add 4.75g of Tween 80 and 60g of water, stir, and let cool to obtain an emulsion;

[0048] (4) Mix the mixture of step (2) and the emulsion of step (3) evenly, the total weight is 500g, pack separately, and obtain.

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Abstract

The invention provides a Gamuzhuer medicinal latex preparation and a preparation method thereof. The Gamuzhuer medicinal latex preparation comprises the following components by weight percentage: 10-40% of Gamuzhuer, 0.1-8% of bioadhesive agent, 0.1-5% of non-ionic emulsifier, 1-30% of glycerol, 0-30% of grease and the balance of water. The bioadhesive material is bond with the Gamuzhuer, so that medicines are dispersed and adhered to a focus part so as to achieve a therapeutic aim; the Gamuzhuer latex preparation has a higher content, is more convenient to administer and is not added with any irritant solvent; the acting time is prolonged; during preparation, a proper amount of emulsifier is added, so that dissolution of musk and borneol can be promoted; compared with the conventional powdery preparation, the latex preparation takes effect more quickly; a proper amount of grease and a proper amount of emulsifier are added to achieve a good lubricating effect; the grain diameter of the medicinal powder is optimized, so that 99 percent of the powder is smaller than 100 um and thus the stability of the medicinal powder is improved; and the medicines have antibacterial and antiseptic functions, so that a preservative is not required.

Description

technical field [0001] The invention relates to a Gamuzhuer emulsion and a preparation method thereof. Background technique [0002] Gamuzhuer, a traditional Mongolian patent medicine, belongs to the classic prescription of Mongolian medicine and has been used in various clinical frontlines in Inner Mongolia for many years. Gamuzhuer is composed of borneol, realgar, cinnabar, silver vermilion, stone cassia, cold water stone, and musk. It has the functions of promoting muscle and astringent. It is used for sores on the mouth and tongue, ulcers, sore throat, skin Ulceration, trauma infection, cervical erosion embolism. Gamuzhuer is a compound preparation, of which 5 ingredients have been included in the 2005 edition of the Chinese Pharmacopoeia, namely realgar, cinnabar, stone cassia, borneol and musk, mostly for reducing swelling and pain, promoting blood circulation and dysmenorrhea, and refreshing , Detoxification insecticide. Yinzhu is recorded in "Compendium of Materia...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/56A61K9/00A61K47/44A61P11/04A61P15/00A61P17/02A61K31/045A61K33/06A61K33/28A61K33/36A61K35/55A61K35/618
Inventor 孔徐生金方雷伯开闻聪王玉杰
Owner SHENZHEN JIAXUAN MEDICAL TECH DEV
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