Functional mycobacterium tuberculosis antigen polypeptide and application thereof

A technology for tuberculosis, active ingredients, applied in the field of functional Mycobacterium tuberculosis antigen polypeptides
CN102653554AActive Publication Date: 2012-09-05INST OF PATHOGEN BIOLOGY CHINESE ACADEMY OF MEDICAL SCI
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
INST OF PATHOGEN BIOLOGY CHINESE ACADEMY OF MEDICAL SCI
Publication Date
2012-09-05

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Abstract

The invention discloses a functional mycobacterium tuberculosis antigen polypeptide and an application thereof. According to the polypeptide disclosed by the invention, an amino acid sequence is represented by a sequence 1 in a sequence table. The polypeptide can stimulate H37Rv infected mice spleen cells and lymphocytes to be obviously multiplied so as to be subjected to an antigen-antibody reaction with infected mice blood serum; and therefore, the polypeptide has the antigen property and can be used for developing novel tuberculosis preventing and treating vaccines.
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Description

technical field

[0001] The present invention relates to functional Mycobacterium tuberculosis antigen polypeptide and its application. Background technique

[0002] According to WHO statistics, nearly 1 / 3 of the world's population is infected with Mycobacterium tuberculosis (M.tb). For several years, tuberculosis ranks the top two in the incidence and death of infectious diseases in my country. Tuberculosis is already an infectious disease that seriously endangers people's health and the national economy, and China is a country with a high burden of tuberculosis, so the formulation of tuberculosis prevention and control strategies has become a major issue related to my country's national economy and people's livelihood. The treatment of tuberculosis is currently the most widely used "chemotherapy". The treatment of chemical drugs has obvious effects on tuberculosis. With the increase of morbidity, chemotherapy has shown its limitations. Then, new prevention and control met...

Claims

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