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Kit for screening colorectal adenomas (CRA)

A kit and colorectal technology, applied in the field of kits for screening colorectal adenomas, can solve problems such as reduced sensitivity

Active Publication Date: 2012-09-12
BEIJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

⑦ CT colonography (CTC) has a sensitivity of 89% for detecting adenomas > 6mm, and the sensitivity of the elderly (over 70 years old) to radioactivity will decrease due to age

Method used

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  • Kit for screening colorectal adenomas (CRA)
  • Kit for screening colorectal adenomas (CRA)
  • Kit for screening colorectal adenomas (CRA)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1, the construction of the kit for screening colorectal adenoma

[0029] 1. Establishment of Molecular Model

[0030] 1. Blood collection, lipid molecule extraction and detection

[0031] 1) Research object

[0032] All samples were collected from May 2007 to May 2010. The samples came from the Second Artillery General Hospital of the PLA, Beijing Hospital, and the Second Affiliated Hospital of Peking University. Blood from fasting patients was taken in the morning for pretreatment. This project was approved by the Institutional Review Board, and all subjects signed informed consent.

[0033] Table 1 summarizes the basic information of the research subjects: 240 subjects were all Chinese, 65.4% were men (157 / 240), and the proportion of men in healthy controls and adenoma patients was 68% and 63%, respectively. The ages of healthy controls and adenoma patients were 55.2+7.5 and 54.5+14.2 respectively, and there was no significant difference in sampling age...

Embodiment 2

[0069] Example 2, application of the kit for screening colorectal adenoma

[0070] 1. Sensitivity and specificity detection of the kit for screening colorectal adenoma

[0071] Blood from 120 colorectal adenomas (all clinically identified) and 120 patients with colorectal tumors (all clinically identified and confirmed) were collected; in vitro plasma preparation, fat 16:0SM, 18:0SM, 14:0LPC, 16:0LPC, 18:2LPC, 18:1LPC, 18:0LPC, 20:4LPC, 20:0LPC, 22:6LPC and 22:0 LPC content;

[0072] Take 0.0093×saturated LPC total amount – 1225×20:4LPC% as the abscissa, take the SM total amount as the vertical coordinate, and use the formula of the model [0.0093×saturated LPC total amount–1225×20:4LPC%+0.02×SM total amount =3.3] Make a straight line and make a graph.

[0073] The result is as figure 2 Shown in the right panel of , the total amount of SM (0.0093 × total saturated LPC - 1225 × 20:4 LPC%) was plotted against the total amount of SM in the plasma of each adenoma patient (a) a...

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Abstract

The invention discloses a kit for screening colorectal adenomas (CRA). The kit for screening or screening CRA in an aided manner comprises a device for detecting the contents of phospholipids and a comparison card established by the contents of phospholipids, wherein the phospholipids include 16:0SM, 18:0SM, 14:0LPC, 16:0LPC, 18:2LPC, 18:1LPC, 18:0LPC, 20:4LPC, 20:0LPC, 22:6LPC and 22:0LPC. A molecular model for distinguishing healthy controls from CRA patients is established by taking saturated LPC, 20:4LPC and SM as markers, and the sensitivity and specificity of the model in distinguishing the CRA are respectively 89% and 80%.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a kit for screening colorectal adenoma. Background technique [0002] Colorectal adenoma (CRA) is a benign lesion with cancerous potential and is a type of colorectal polyp. Colorectal polyps refer to vegetations that are higher than the mucosa and protrude toward the intestinal cavity, and can be pedunculated or broad-based without stalks. Clinically diagnosed colorectal polyps include neoplastic polyps and non-neoplastic polyps pathologically, while colorectal adenomas are classified as neoplastic polyps. [0003] According to the new WHO definition of colorectal cancer, colorectal adenoma can also be called colorectal intraepithelial neoplasia, which refers to colorectal mucosal epithelium with histological and cytological atypia, but this change does not break through the mucosal muscle. Once it breaks through the muscular mucosa and enters the submucosa, it is colorectal cance...

Claims

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Application Information

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IPC IPC(8): G01N30/02
Inventor 张俊杰宋建稳李颂徐燕桑建利丛羽生
Owner BEIJING NORMAL UNIVERSITY
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