Use of shea butter as transdermal osmosis promoter

The technology of a transdermal penetration enhancer and shea butter is applied in the directions of emulsion delivery, aerosol delivery, oil/fat/wax inactive ingredients, etc. And other issues

Inactive Publication Date: 2012-09-19
HENAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the low rate of drug transdermal absorption is the main disadvantage of this method of administration, which limits its wide application.

Method used

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  • Use of shea butter as transdermal osmosis promoter

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0008] The transdermal penetration promoting effect test of embodiment shea butter

[0009] 1. Preparation of test drugs

[0010] 1.1 Preparation of lidocaine cream

[0011] The preparation process is:

[0012] (1) Prepare the oil phase: add 15.0 g of liquid paraffin, 15.0 g of white oil, and 5.0 g of shea butter to 10.0 g of simethicone oil, and stir evenly;

[0013] (2) Prepare the water phase: Dissolve 1.0g Carbomer ultrez-10 in 100.0g water, add 5.0g glycerin, 5.0g PEG-400, stir for 10 minutes, add 5.0g lidocaine, and finally add 5.0g emulsifier Sorbitol fat, stirred for 10 minutes;

[0014] (3) Heat the oil phase prepared in step (1) and the water phase prepared in step (2) in a water bath at 70°C, then add the water phase to the oil phase, stir and cool to room temperature, and use the concentration mass fraction Adjust the pH to 6.5 with 15% NaOH and prepare a cream.

[0015] 1.2 Preparation of control drugs

[0016] The shea butter in the step (1) is replaced wit...

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Abstract

The invention relates to the technical field of medicinal materials, and in particular discloses use of shea butter as a transdermal osmosis promoter. Mouse skin stimulus and sensitization trials and in-vitro transdermal trials prove that the shea butter has a good transdermal osmosis effect, has a stronger transdermal osmosis capability compared with azone, does not irritate skin and sensitize, and can be used as the new transdermal osmosis promoter.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to the application of shea butter as a transdermal penetration enhancer. Background technique [0002] Transdermal Therapeutic System (TTS for short) refers to a controlled-release preparation that is administered through the skin and has a systemic therapeutic effect. The TTS system has the unique advantage of surpassing the general drug administration method. It can provide a predictable and long-term action time without going through the "first-pass effect" of the liver and the destruction of the gastrointestinal tract, maintain a stable and long-lasting blood concentration, and reduce The frequency of administration, the convenience of administration, etc. However, the low rate of drug transdermal absorption is the main disadvantage of this drug delivery method, which limits its wide application. Therefore, it is very important to develop new and effective transderma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/44A61K9/06
Inventor 梁菊吴文澜张延萍周冬菊陈雅维陈姗董亚南
Owner HENAN UNIV OF SCI & TECH
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