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Method for measuring carbonic acid content in Sevelamer carbonate

A technique for the determination of sevelamer carbonate and its method, which is applied in the field of determination of carbonic acid content in sevelamer carbonate, achieving the effects of strong specificity, strong operability, and clear principle of the method

Inactive Publication Date: 2012-09-19
NANJING LIFENERGY R & D
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] The object of the present invention is to provide a kind of assay method of carbonic acid content in sevelamer carbonate, this method is simple, accurate, with low cost and easy to implement

Method used

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  • Method for measuring carbonic acid content in Sevelamer carbonate
  • Method for measuring carbonic acid content in Sevelamer carbonate
  • Method for measuring carbonic acid content in Sevelamer carbonate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Precisely weigh about 1.0 g of the raw material of sevelamer carbonate (Nanjing Life Energy Technology Development Co., Ltd., batch number: 101001), put it in a 50 ml sample container 5, add 20 ml of water; add 50 ml of 0.1 mol / L NaOH solution (pH value 13 ) in three gas absorption pools 8; figure 1 In the test device shown, except for the carrier gas source and the vent and exhaust port of the flow control valve 1, the remaining ports are sealed; high-purity nitrogen gas is introduced, and the flow measuring instrument 2 is controlled so that the flow rate is 10-30ml / min. Turn on the heating and stirring device 6, and only in the stirring state, use a syringe to inject 6ml of 4mol / L hydrochloric acid solution into the sample container 5 through the liquid adding device 3, and after continuing to ventilate for about 30 minutes, combine the solutions in the gas absorption cell 8. According to potentiometric titration, titrate the combined absorption solution with 0.5mol / ...

Embodiment 2

[0066] Accurately weigh about 1.0 g of the raw material of sevelamer carbonate (Nanjing Life Energy Technology Development Co., Ltd., batch number: 101001), put it in a 50 ml sample container 5, add 20 ml of water; add 50 ml of 2 mol / L NaOH solution (pH value 14.3) In a gas absorption pool 8; adopt such as figure 1 In the test device shown, except for the carrier gas source and the vent port and exhaust port of the flow control valve 1, the other ports are sealed; high-purity argon gas is introduced, and the flow measuring instrument 2 is controlled to make the flow rate 70-100ml / min. Turn on the heating and stirring device 6, and only in the stirring state, use a syringe to inject 6ml6mol / L perchloric acid solution into the sample container 5 through the liquid adding device 3, and after continuing to ventilate for about 30 minutes, combine the solutions in the gas absorption cell 8. According to potentiometric titration, titrate the combined absorption solution with 0.5mol / L...

Embodiment 3

[0068] Accurately weigh about 1.0 g of the raw material of sevelamer carbonate (Nanjing Life Energy Technology Development Co., Ltd., batch number: 101001), and put it in a 50 ml sample container 5; add 100 ml of 0.05 mol / L KOH solution (pH value 12.7) to In a gas absorption cell; using such as figure 1 In the test device shown, except for the carrier gas source and the vent port and exhaust port of the flow control valve 1, the remaining ports are sealed; high-purity argon gas is introduced, and the flow measuring instrument 2 is controlled to make the flow rate 10-30ml / min. In the stirring state, use a syringe to inject 26ml of 1mol / L sulfuric acid solution into the sample container 5 through the liquid adding device 3, and after continuous ventilation for about 30 minutes, combine the absorption liquid. According to potentiometric titration, titrate the combined absorption solution with 0.5mol / L hydrochloric acid titration solution. Carry out a blank test at the same time,...

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Abstract

The invention discloses a method for measuring carbonic acid content in Sevelamer carbonate. The method includes: converting carbonic acid in Sevelamer carbonate to carbon dioxide in the condition of heating and / or adding excessive acid, conveying carbon dioxide into alkaline solution by aid of carrier gas, and measuring absorptive amount of carbon dioxide in alkaline solution to obtain carbonic acid content in Sevelamer carbonate. The method can effectively control the quality of Sevelamer carbonate and has the advantages of being clear in method principle, strong in specificity, high in accuracy, good in precision degree, low in cost, strong in operability and the like, and in addition, inspection devices are simple and can be obtained easily.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a method for determining the content of carbonic acid in sevelamer carbonate. Background technique [0002] It is well known that hyperphosphatemia is common in patients with end-stage renal disease, and hyperphosphatemia can cause hyperparathyroidism and osteodystrophy. Recent studies have found that hyperphosphatemia can still induce soft tissue and vascular calcification, which is an important factor for the increased mortality and cardiovascular disease incidence in patients with end-stage renal disease. Therefore, effective control of serum phosphorus levels has become an important measure to reduce the mortality and incidence of cardiovascular diseases in patients with end-stage renal disease. At present, the treatment of hyperphosphatemia mainly includes dietary phosphorus restriction, dialysis treatment, application of phosphorus binders and removal of parathyroid gla...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/44G01N27/42G01N21/79
Inventor 胡俊胡良明汤传飞方文
Owner NANJING LIFENERGY R & D
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