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Nano-silver antibacterial hydrogel and preparation method thereof

A nano-silver antibacterial and hydrogel technology, which is applied in medical science, surgery, prosthesis, etc., can solve the problems affecting the biocompatibility of antibacterial hydrogel, and achieve good adhesion and skin tissue regeneration and good structure The effect of uniformity and good biocompatibility

Inactive Publication Date: 2014-07-16
北京同威典石技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Acrylamide monomer has strong cytotoxicity, and the residual toxicity of the material will seriously affect the biocompatibility of antibacterial hydrogels

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035]10g carboxymethyl chitosan / gelatin mass ratio is 3: 2 powder and 90g silver nitrate aqueous solution (silver nitrate mass fraction is 0.15%) mixes, stirs evenly with defoaming mixer, obtains the aqueous solution that solid content is 10%. Put the aqueous solution into the test tube, remove the air bubbles, and seal it with 60 Co γ-rays were irradiated to 30kGy to obtain nano-silver antibacterial hydrogels. The cross-linking degree of the obtained nano-silver antibacterial hydrogel sample can reach more than 60%, the water absorption rate is 180 times, the compression modulus is 45kPa, the porosity is more than 90%, and the diameter of the nano-silver is 10-30nm. 0.4g sample in 12 hours to 40ml 10 5 The Escherichia coli bacteriostatic rate of CFU / ml can reach more than 99%.

Embodiment 2

[0037] 10g carboxymethyl chitosan / gelatin mass ratio is 3: 2 powder and 90g silver nitrate aqueous solution (silver nitrate mass fraction is 0.08%) mix, stir with defoaming mixer, obtain the aqueous solution that solid content is 10%. Put the aqueous solution into the test tube, remove the air bubbles, and seal it with 60 Co γ-rays were irradiated to 30kGy to obtain nano-silver antibacterial hydrogels. The cross-linking degree of the obtained nano-silver antibacterial hydrogel sample can reach more than 60%, the water absorption rate is 160 times, the compressive modulus is 44kPa, the porosity is more than 90%, and the diameter of the nano-silver is 5-10nm. 0.4g sample in 12 hours to 40ml 10 5 The Escherichia coli bacteriostatic rate of CFU / ml can reach more than 50%.

Embodiment 3

[0039] 10g carboxymethyl chitosan / gelatin mass ratio is 3: 2 powder and 90g silver nitrate aqueous solution (silver nitrate mass fraction is 0.03%) mixes, stirs evenly with defoaming mixer, obtains the aqueous solution that solid content is 10%. Put the aqueous solution into the test tube, remove the air bubbles, and seal it with 60 Co γ-rays were irradiated to 30kGy to obtain nano-silver antibacterial hydrogels. The cross-linking degree of the obtained nano-silver antibacterial hydrogel sample can reach more than 60%, the water absorption rate is 140 times, the compression modulus is 52kPa, the porosity is more than 90%, and the diameter of the nano-silver is 3-6nm. 0.4g sample in 12 hours to 40ml 10 5 The Escherichia coli bacteriostasis rate of CFU / ml can reach more than 30%.

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PUM

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Abstract

The invention discloses nano-silver antibacterial hydrogel and a preparation method thereof, wherein the antibacterial hydrogel does not contain a chemical cross-linking agent, a cross-linking sensitizing agent and a cross-linking initiator; the porosity is above 90%; the cross-linking degree is above 50%; by weight, the nano-silver antibacterial hydrogel comprises 3-20% of natural polymer or a derivative thereof, 0-20% of synthetic polymer and 0..005-0.2% of nano-silver; and the nano-silver antibacterial hydrogel is prepared by blending the natural polymer or the derivative thereof, the synthetic polymer, a compound containing silver ions and water and then adopting a radiation cross-linking method. The nano-silver antibacterial hydrogel disclosed by the utility model has good biocompatibility and uniform nano-silver distribution and slow-release capability and is capable of effectively inhibiting bacteria, such as escherichia coli.

Description

technical field [0001] The invention relates to the preparation of biological materials, in particular to a nano-silver antibacterial hydrogel and a preparation method thereof. The nano-silver antibacterial hydrogel is suitable for but not limited to the field of biomedical materials. Background technique [0002] Infection is one of the most common complications in burn care. Loading antimicrobial agents on dressings is the easiest and easiest way to protect wounds and prevent infection. Clinically, antibiotics are often added to dressings to treat burns. Antibiotics have a rapid antibacterial effect, but long-term use can easily lead to drug resistance of bacteria. Today, some bacteria are difficult to kill with antibiotics. The antibacterial effect of silver and its compounds is well known, among which Ag + It can hinder the normal metabolism of bacteria, inhibit DNA replication, destroy bacterial transmission and respiratory system, etc., and has broad-spectrum and hi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/42A61L15/44A61L27/52A61L27/54A61L27/56A61L31/14A61L31/16
Inventor 许零周英翟茂林
Owner 北京同威典石技术有限公司
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