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Microfluidic chip with symmetrical semi-cylindrical grooves on side wall

A microfluidic chip and semi-cylindrical technology, which is applied in the direction of laboratory appliances, laboratory containers, chemical instruments and methods, etc., can solve the problems of complex preparation of micro-mixers and poor mixing effects, and achieve micro-mixing Enhanced Effects, Simple Design, Good Mix Effects

Inactive Publication Date: 2012-10-17
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned methods either have a complicated process of preparing the micro-mixer, or the effect of mixing is not good

Method used

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  • Microfluidic chip with symmetrical semi-cylindrical grooves on side wall
  • Microfluidic chip with symmetrical semi-cylindrical grooves on side wall
  • Microfluidic chip with symmetrical semi-cylindrical grooves on side wall

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Experimental program
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Effect test

specific Embodiment approach 1

[0014] Specific implementation mode one: as Figure 1~2 As shown, the microfluidic chip with a symmetrical semi-cylindrical groove on the side wall of this embodiment is composed of a substrate 1 and a PDMS polymer 2, and its invention is symmetrical along the channel direction on the side wall of the channel 3 of the PDMS polymer 2. There are several semi-cylindrical grooves 4, and the processing method is as follows:

[0015] 1. Preparation of micro-mixer with symmetrical semi-cylindrical grooves on the side wall:

[0016] 1) Cleaning of glass slides: The glass substrate was ultrasonically cleaned in ultrapure water for 5 minutes, blown dry with nitrogen, and then ultrasonically cleaned with acetone, methanol, and isopropanol for 5 minutes, and blown dry with nitrogen. The solutions used for cleaning are all analytical reagents.

[0017] 2) Mask: Use Clewin 4 software to design a structure with symmetrical semi-cylindrical grooves on the side wall (channel 200μm×100μm, gro...

specific Embodiment approach 2

[0022] Embodiment 2: This embodiment is different from Embodiment 1 in that, for solutions with different mixing coefficients, such as solutions of biomolecules such as hemoglobin, the mixer also significantly enhances the mixing effect. Such as Figure 5 As shown, for the hemoglobin solution, the mixing effect with the symmetrical semi-cylindrical groove structure is 2.18 times better than that without the groove.

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Abstract

The invention relates to a microfluidic chip, in particular to a microfluidic chip with symmetrical semi-cylindrical grooves on a side wall, which consists of a substrate (1) and PDMS (polydimethylsiloxane) (2). A plurality of semi-cylindrical grooves (4) are symmetrically arranged on the side wall of a passage (3) of the PDMS (2) along the passage direction. With the adoption of the symmetrical semi-cylindrical grooves embedded on the side wall, the micro-mixing effect is obviously increased. The microfluidic chip with the symmetrical semi-cylindrical grooves on the side wall has the advantages of simple design, good mixing effect and low cost, is applicable to mix the fluid of different diffusion coefficients and has great applicable prospect in scientific research, in particular to microfluidic analysis detection, and the depth and the size of the grooves are controllable. The design concept of the grooves has wide application in the field of chemical engineering.

Description

technical field [0001] The invention relates to a microfluidic chip. Background technique [0002] Microfluidic chip technology is a new technology that can be applied to chemical synthesis analysis and detection. The micro-mixing effect is one of the most crucial steps. Many scientists at home and abroad are conducting research on the enhancement of micro-mixing effects, including the method of embedding obstacles, and the method of using special structures to induce turbulence. However, the above-mentioned methods either have a complicated process of preparing the micromixer, or the mixing effect is not good. Contents of the invention [0003] Aiming at the problems existing in the prior art, the present invention provides a microfluidic chip with symmetrical semi-cylindrical grooves on the side wall. The microfluidic chip has simple design and good mixing effect. [0004] The microfluidic chip with symmetrical semi-cylindrical grooves on the side wall of the present ...

Claims

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Application Information

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IPC IPC(8): B01L3/00
Inventor 韩晓军王磊
Owner HARBIN INST OF TECH
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