Crystallization-type ilaprazole sodium and preparation method thereof
A technology of ilaprazole sodium and crystal form, applied in the field of new crystal form of ilaprazole sodium and its preparation, can solve the problem that there is no crystal form of ilaprazole sodium, limited clinical application, rebound of gastric acid secretion, etc. problem, to achieve the effect of easy preparation, low preparation cost and less solvent
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[0032] Example 1
[0033] At 25°C, put 49 mg of ilaprazole sodium in a beaker, add 0.18 mL of n-propanol and stir to dissolve it. After 1 hour, the solvent has evaporated and dried under vacuum. 48 mg of white crystalline powder was obtained, and the yield was 98%.
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[0034] Example 2
[0035] At 25°C, put 49 mg of ilaprazole sodium in a beaker, add 0.18 mL of n-propanol and stir to dissolve it. After 1 hour, the solvent has evaporated and dried under vacuum. 46.2 mg of white crystalline powder was obtained, and the yield was 96%.
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[0036] Example 3
[0037] At 30°C, take 115 mg of ilaprazole sodium in a test tube, add 0.3 mL of n-propanol to prepare a supersaturated solution, sonicate for 1 hour, filter, and vacuum dry. 71 mg of white crystalline powder was obtained, and the yield was 61.7%.
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