Splitting process of racemic para hydroxybenzene glycine

Abstract

The invention relates to a splitting process of racemic para hydroxybenzene glycine. As to the problems that the splitting process of the racemic para hydroxybenzene glycine is high in price, much high-concentration waste water is generated in a production process, and pollution on the environment is easily generated at present, the splitting process of the racemic para hydroxybenzene glycine is characterized by comprising the steps of: dispersing 1mol of complex salt prepared from L-p-hydroxyphenylglycine glycine and D-ethyl benzene sulfonic acid into 20mol of water by a hydrolysis process, and slowly dropping inorganic base solution to neutralize until the pH is 4-8; devitrifying, separating, washing and drying the solution to obtain the L-p-hydroxyphenylglycine glycine, storing the mother liquid for use at low temperature; dissolving 1mol of 98% concentrated sulfuric acid into 20mol of water by the splitting process, adding racemic para hydroxybenzene glycine and the mother liquor, then adding 0.05mol of catalyst to reflux for 10-20 hours; devitrifying, separating, washing and drying the solution to obtain the complex salt of the L-p-hydroxyphenylglycine glycine and D-ethyl benzene sulfonic acid, and applying the hydrolysis process and splitting process in circulation until the concentration of inorganic salt of the mother liquid is saturated. According to the invention, racemization and splitting integration is achieved; and the conversion per pass is kept over 80%, and the reaction efficiency is high.

Description

technical field [0001] The invention relates to a resolution process of spun p-hydroxyphenylglycine. Background technique [0002] At present, there are mainly enzymatic and chemical methods for the resolution of hydroxyphenylglycine. The resolution enzymes used in the enzymatic method are very expensive, and a large amount of high-concentration wastewater will be generated during the production process, which will pollute the environment; while chemical methods There are disadvantages such as long route, complicated process, low conversion rate or expensive resolving agent. Contents of the invention [0003] Aiming at the defects in the prior art, the present invention provides a process for dismantling spun p-hydroxyphenylglycine, which has high reaction efficiency, high single-pass conversion rate and less waste generated. [0004] For this reason, the present invention adopts the following technical scheme: a kind of splitting process of mixed-rotational p-hydroxyphen...

AI Technical Summary

Problems solved by technology

[0002] At present, there are mainly enzymatic and chemical methods for the resolution of hydroxyphenylglycine. The resolution enzymes used in the enzymatic method are very expensive, and a large amount of high-concentration wast

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