Novel antitumor component Swertiridoid A in swertia phragmitiphylla
An anti-tumor technology, applied in the field of medicine, can solve problems such as unreported chemical components, achieve the effects of good water solubility, avoid silica gel separation, and simple preparation method
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Embodiment 1
[0022] Example 1 The preparation method of the new anti-tumor component Swertiridoid A in the Swertia reed leaf comprises the following steps:
[0023] ⑴Extraction: First, dry the Swertia reed in the shade, cut the whole herb, soak it in ethanol with 10 times its weight and 95% volume concentration for 10 hours, heat and reflux at 80°C for 2 extractions, 2 hours each time, Concentrate under reduced pressure at 0~0.08MPa, recover ethanol, and obtain an extract with a mass content of 20~25%; then refrigerate the extract at 0~5°C for 36 hours, and refrigerate it at 0~10000 rpm Centrifuge at a high speed, take the supernatant and recover ethanol under reduced pressure under the condition of 0~0.08MPa to obtain an extract with a specific gravity of 1.1~1.3; finally, extract the extract at a mass volume ratio of 1:4 (kg / mL ) was dispersed in water, and extracted several times with petroleum ether, ethyl acetate, and n-butanol in the same volume as the dispersed water, respectiv...
Embodiment 2
[0025] Example 2 The preparation method of the new anti-tumor component Swertiridoid A in the Swertia reed leaf comprises the following steps:
[0026] ⑴Extraction: First, dry the Swertia reed leaf in the shade, cut the whole grass, soak it in ethanol with 20 times its weight and 95% volume concentration for 14 hours, heat and reflux at 90°C for 4 times, 2 hours each time, Concentrate under reduced pressure at 0~0.08MPa, recover ethanol, and obtain an extract with a mass content of 20~25%; then refrigerate the extract at 0~5°C for 60 hours, and refrigerate it at 0~10000 rpm Centrifuge at a high speed, take the supernatant and recover ethanol under reduced pressure under the condition of 0~0.08MPa to obtain an extract with a specific gravity of 1.1~1.3; finally, extract the extract at a mass volume ratio of 1:6 (kg / mL ) was dispersed in water, and extracted several times with petroleum ether, ethyl acetate, and n-butanol in the same volume as the dispersed water, respectiv...
Embodiment 3
[0028] Example 3 The preparation method of the new anti-tumor component Swertiridoid A in the Swertia reed leaf comprises the following steps:
[0029] ⑴Extraction: First, dry the Swertia reed leaf in the shade, cut the whole grass, soak it in ethanol with 15 times its weight and a volume concentration of 95% for 12 hours, heat and reflux at 85°C for 3 times, 2 hours each time, Concentrate under reduced pressure at 0~0.08MPa, recover ethanol, and obtain an extract with a mass content of 20~25%; then refrigerate the extract at 0~5°C for 48 hours, and refrigerate it at 0~10000 rpm Centrifuge at a high speed, take the supernatant and recover ethanol under reduced pressure under the condition of 0~0.08MPa to obtain an extract with a specific gravity of 1.1~1.3; finally, extract the extract at a mass volume ratio of 1:5 (kg / mL ) was dispersed in water, and extracted several times with petroleum ether, ethyl acetate, and n-butanol in the same volume as the dispersed water, resp...
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