Traditional Chinese drug component composition for treating stomach ulcer and duodenal ulcer, and preparation thereof

Abstract

The invention discloses a traditional Chinese drug component composition for treating stomach ulcer and duodenal ulcer, wherein the composition is prepared from berberine hydrochloride, curcumin and common bletilla tuber polysaccharide according to a certain weight part ratio, and is prepared into an oral administration formation such as powder, granule, tablet, capsule, pill, oral liquid, syrup, emulsion, suspension, and the like. According to the present invention, 1) significant bactericidal killing and bacterial inhibiting effects on helicobacter pylori are provided; 2) effects of inhibition of H<+> / K<+>-ATP enzyme activity, reduction of gastric juice amount, reduction of gastric free acid, reduction of the total acid discharge, reduction of pepsin discharge, analgesic, and anti-inflammation are provided; and 3) functions of promotion of wound surface tissue cell proliferation, promotion of healing quality and speed of gastrointestinal mucous membrane tissue, and improvement of barrier function of gastrointestinal mucous membrane are provided. Animal experiment results show that the traditional Chinese drug component composition has pharmacologic actions of significant reduction of ulcer indexes of a hydrochloric acid / ethanol type animal stomach ulcer model, a cold water stress type animal stomach ulcer model, a pylorus ligation type animal stomach ulcer model, and other animal stomach ulcer models, inhibition and killing of helicobacter pylori, inhibition of gastric juice secretion, and the like, and can be used as a drug for treating stomach ulcer and duodenal ulcer.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and relates to a combination of traditional Chinese medicine components for treating gastric and duodenal ulcers, in particular to a combination of traditional Chinese medicine components and preparations thereof for treating gastric and duodenal ulcers. Background technique [0002] Stomach and duodenal ulcers are common clinical diseases and frequently-occurring diseases, manifested by symptoms such as epigastric pain, loss of appetite, vomiting, pantothenic acid, and weight loss. They are prone to bleeding, perforation, obstruction and cancer, which seriously endanger human health. Studies have shown that gastric and duodenal ulcers are caused by five major factors: bile reflux, hyperacidity, hypomotility, decreased gastrointestinal mucosal defenses, and Helicobacter pylori (Hp) infection, including Hp infection, Excessive gastric acid secretion and decreased gastrointestinal...

AI Technical Summary

Problems solved by technology

However, a single antibacterial drug or two drugs have poor curative effect; bismuth triple therapy (bismuth + two antibiotics) has an eradication rate of about 90%, but its adverse reactions are serious, the dosage is large, and the treatment cost is expensive; antisecretory drugs and Antimicrobial Combination Therapies Are Poorly Tolerated

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