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Sustained-release preparation for water-soluble pesticide and preparation method of sustained-release preparation
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A controlled-release preparation and water-soluble technology, which is applied in the field of pesticide preparation processing, can solve problems such as complex structure preparation procedures, achieve considerable application prospects, simple preparation process, and reduce manpower, material and financial costs.
Active Publication Date: 2014-06-25
INST OF ENVIRONMENT & SUSTAINABLE DEV IN AGRI CHINESE ACADEMY OF AGRI SCI
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In this composite material, calcium alginate only acts as a coating layer, and the active pharmaceutical ingredients are loaded in diatomite. The structure of the composite material and the corresponding preparation process are slightly complicated.
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Embodiment 1
[0034] Example 1 Preparation and structural characterization of calcium alginate nanospheres
[0035] Add 5ml of 0.1wt% sodium alginate aqueous solution to the conical flask, under magnetic stirring, add 1.15ml of isopropanol and 1.8ml of cyclohexane in turn, stir evenly, and let stand for 30min. Then, 0.6 g of dodecyltrimethylammonium bromide (CTAB) was added to the above mixed solution, and the stirring was continued until it was completely dissolved to form a stable inverse microemulsion. Then, 0.1ml of 2mol / L CaCl was added dropwise to the inverse microemulsion 2 Aqueous solution, stirring evenly, ultrasonically dispersing, and reacting for 1 h to obtain a uniformly dispersed calcium alginate nano-microsphere suspension. The suspension was placed in a high-speed centrifuge, centrifuged at 50,000 r / min for 5 min, and the supernatant was discarded. Isopropanol was added to the centrifugal precipitate for cleaning, centrifuged again at a speed of 50,000 r / min for 5 min, rep...
Embodiment 2
[0037] Example 2 Preparation of 10wt% Jinggangmycin-calcium alginate nano-microsphere sustained-release preparation
[0038] Add 0.5ml of 0.1wt% Jinggangmycin aqueous solution to the conical flask, under magnetic stirring, add 0.0045g of sodium alginate, stir well until completely dissolved, then add 1.15ml of isopropanol and 1.8ml of cyclohexane in turn, stir Evenly, let stand for 30min. Add 0.6 g of CTAB to the above mixed solution, and continue to stir until it is completely dissolved to form a stable inverse microemulsion. Then, 0.1ml of 2mol / L CaCl was added dropwise to the inverse microemulsion 2 The solution was stirred evenly, and ultrasonically dispersed for 1 hour to obtain a uniformly dispersed Jinggangmycin-calcium alginate nano-microsphere suspension. The suspension was placed in a high-speed centrifuge, centrifuged at a speed of 50,000 r / min for 5 min, and the supernatant was discarded. Add isopropanol to the centrifugal sediment for cleaning, centrifuge again...
Embodiment 3
[0039] Example 3 Preparation of 25wt% Jinggangmycin-calcium alginate nano-microsphere sustained-release preparation
[0040] The steps of Example 2 were repeated, except that the concentration of the Jinggangmycin aqueous solution was changed from 0.1 wt% to 0.3 wt%, and finally a 25 wt% Jinggangmycin-calcium alginate nano-microsphere slow-release preparation was obtained.
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Abstract
The invention provides a sustained-release preparation for water-soluble pesticide. In the sustained-release preparation, calcium alginate nano microballs are used as carriers, and the water-soluble pesticide carried on the carriers are used as active components. Preferably, the water-soluble pesticide is validamycin. The sustained-release preparation for the water-soluble pesticide can effectively control release speed of the pesticide, action time is prolonged, pesticide application times are reduced, cost is saved, and environmental pollution is reduced. Meanwhile, the active components in the pesticide can be prevented from degradation during use, effective utilization rate is increased. The carriers are degradable and free of secondary pollution. The invention further provides a preparation method of the sustained-release preparation for the water-soluble pesticide. The preparation method is mild in reaction conditions and simple in preparation process, and particle size, hole structure and pesticide carrier quantity of the sustained-release preparation can be controlled during preparation.
Description
technical field [0001] The invention relates to the field of pesticide preparation processing, in particular to a water-soluble pesticide sustained and controlled release preparation and a preparation method thereof. Background technique [0002] Pesticide is an important material basis for preventing major biological disasters, ensuring national grain production, and promoting the sustained and stable growth of agricultural output. According to the United Nations Food and Agriculture Organization (FAO) statistics, the loss of agricultural products recovered by the use of pesticides to control pests and diseases in the world accounts for about 30% of the total food production. my country's agricultural biological disasters occur very frequently, posing a major threat to food security. The annual chemical control area reaches 400 million hectares, and China has become the world's largest producer and user of pesticides. After years of development, my country has formed a rel...
Claims
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Patent Type & Authority Patents(China)
IPC IPC(8): A01N25/08A01N43/16A01P3/00
Inventor 姜建芳崔海信
Owner INST OF ENVIRONMENT & SUSTAINABLE DEV IN AGRI CHINESE ACADEMY OF AGRI SCI
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