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Method for preparing mental stress relieving tablets

A Xinning Tablets, extraction technology, applied in the field of preparation of Xinning Tablets, can solve the problems of many impurities, rough process, large dosage for patients, etc.

Inactive Publication Date: 2012-12-19
NANJING ZHENGLIANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of Xinning Tablets. However, the method of powdering and decocting in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take. Seriously affected the clinical application of this product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Take 300g of Salvia miltiorrhiza, 150g of Sophora japonica, 150g of Chuanxiong, 54g of Panax notoginseng, 150g of safflower, 150g of Jiangxiang, 150g of Radix Paeoniae Rubra, add Chuanxiong, safflower and Jiangxiang to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 4% by volume of the total extraction solvent. The extraction pressure is 15MPa, the temperature is 30°C, and the CO 2 The flow rate is 1m1 / g crude drug·min, the extraction time is 150min, and the supercritical extract is obtained for later use; take Salvia miltiorrhiza, Sophora japonica, Panax notoginseng, and Radix Paeoniae Rubra, grind them, add 2L of 70% ethanol, and put them into a microwave extraction device for microwave extraction. Extraction power 400W, extraction 2 times, 4 minutes each time, combined extracts, concentrated, added to D101 macroporous adsorption resin column, eluted with 50% ethanol, collected 5 times column volume eluate, recovered e...

Embodiment 2

[0026] Take 300g of Salvia miltiorrhiza, 150g of Sophora japonica, 150g of Chuanxiong, 54g of Panax notoginseng, 150g of safflower, 150g of Jiangxiang, 150g of Radix Paeoniae Rubra, add Chuanxiong, safflower and Jiangxiang to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained for later use; take Salvia miltiorrhiza, Sophora japonica, Panax notoginseng, and Radix Paeoniae Rubra, grind them, add 2L of 70% ethanol, and put them into a microwave extraction device for microwave extraction. Extraction power 600W, extraction 2 times, 8 minutes each time, combined extracts, concentrated, added to D101 macroporous adsorption resin column, eluted with 50% ethanol, collected 5 times column volume eluate, recove...

Embodiment 3

[0029] Take 300g of Salvia miltiorrhiza, 150g of Sophora japonica, 150g of Chuanxiong, 54g of Panax notoginseng, 150g of safflower, 150g of Jiangxiang, 150g of Radix Paeoniae Rubra, add Chuanxiong, safflower and Jiangxiang to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2m1 / g crude drug·min, the extraction time is 160min, and the supercritical extract is obtained for later use; take Salvia miltiorrhiza, Sophora japonica, Panax notoginseng, and Radix Paeoniae Rubra, grind them, add 2L of 70% ethanol, and put them into a microwave extraction device for microwave extraction. Extraction power 500W, extraction 2 times, 6 minutes each time, combined extracts, concentrated, added to D101 macroporous adsorption resin column, eluted with 50% ethanol, collected 5 times column volume eluate, recovered...

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Abstract

The invention provides a method for preparing mental stress relieving tablets. According to the method, 300g of salviae miltiorrhizae, 150g of pagoda tree flower, 150g of rhizoma chuanxiong, 54g of panax notoginseng, 150 of safflower 150g of lignum dalbergiae odoriferae and 150g of red peony root are used as bulk pharmaceutical chemicals, and the mental stress relieving tablets are prepared through supercritical extraction and microwave-assisted extraction, so that the content of ferulic acid is greatly improved.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method of Xinning tablets. Background technique [0002] Xinning tablet is recorded in the standard WS3-B-0233-90 of the Ministry of Health. It is made of 300g of salvia miltiorrhiza, 150g of Sophora japonica, 150g of chuanxiong, 54g of notoginseng, 150g of safflower, 150g of jiangxiang, and 150g of red peony as raw materials. Pain relief, promoting blood circulation and removing blood stasis. For coronary heart disease, angina pectoris. [0003] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of Xinning Tablets. However, the method of powdering and decocting in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take. Seriously affected the clinical application of this product. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61K9/20A61P9/10
Inventor 不公告发明人
Owner NANJING ZHENGLIANG MEDICAL TECH