Chemical profile of detecting bioactive components of quinones, stilbenes, flavones and alkaloids

一种化学特征、化合物的技术，应用在检测醌类,二苯乙烯类,黄酮类及生物碱类组合物的化学特征分析领域，能够解决内容成分复杂、不易管控其质量、尚未出现等问题

Active Publication Date: 2013-01-02
KAOHSIUNG MEDICAL UNIVERSITY
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  • Abstract
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  • Claims
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Problems solved by technology

However, since Sanhuang Xiexin Decoction is a traditional Chinese medicine compound, its content is complex and its quality is difficult to control
Furthermore, there is currently no technology on the market that can identify traditional Chinese medicine compounds, single traditional Chinese medicines or health foods that claim to contain rhubarb, scutellaria baicalensis and / or Coptis chinensis

Method used

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  • Chemical profile of detecting bioactive components of quinones, stilbenes, flavones and alkaloids
  • Chemical profile of detecting bioactive components of quinones, stilbenes, flavones and alkaloids
  • Chemical profile of detecting bioactive components of quinones, stilbenes, flavones and alkaloids

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Embodiment Construction

[0016] The invention proposed by the application will be fully understood by the following examples, so that those skilled in the art can complete accordingly, but the implementation of the present invention can not be limited to its implementation form by the following examples, those skilled in the art People can still deduce other embodiments according to the spirit of the disclosed embodiments, and these embodiments should all belong to the scope of the present invention.

[0017] 1. The safety of Sanhuang Xiexin Decoction in animal models

[0018] The most common clinical side effect of Sanhuang Xiexin Decoction is diarrhea, and its safety should be considered if it is taken for a long time. In this experiment, whether diarrhea occurs in mice taking different formulations of Sanhuang Xiexin Decoction, in order to evaluate the feasibility of long-term administration of Sanhuang Xiexin Decoction. The experimental mice were C 57BL / 6 mice of about 30 g, and their body weight...

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Abstract

Disclosed are a method for analyzing chemical profiles of components from a herbal medicine product. Components may include quinone (including rhein, sennoside A and / or aloe-emodin), stilbene containing resveratroloside, flavone including baicalin, and / or alkaloid including berberine and / or palmatine. The method includes steps of: (a) respectively chromatographing a methanol extract of product and standard(s) corresponding to the component(s) using HPLC; (b) comparing HPLC chromatogram of extract and standard(s); and (c) analyzing the chemical profiles of the product from the comparison results.

Description

technical field [0001] The present invention relates to a chemical profile analysis of biologically active substances, in particular to a chemical profile analysis for detecting quinones, stilbenes, flavonoids and alkaloids. Background technique [0002] Rhubarb (Rheum palmatum) belongs to the perennial herbaceous plant of the genus Rhubarb in the Liaceae family. It is often used as a laxative and fire medicine in traditional Chinese medicine. Its rhizome contains anthraquinone compounds, such as emodin and rhein, and is used as a weight-loss medicine. drug ingredients. Rhubarb leaves contain sennosides. The active compounds in rhubarb include sennoside B, sennoside A, aloe-emodin, emodin, emodin, rhubarb rhizolol, etc. [0003] Scutellaria baicalensis is a perennial herb belonging to the Lamiaceae family. In traditional Chinese medicine, its roots have the functions of clearing away heat and dampness, purging fire and detoxification, stopping bleeding, and preventing mis...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
CPCA61K31/00G01N30/88G01N2030/8813
Inventor 张芳荣吴东颖吴永昌
Owner KAOHSIUNG MEDICAL UNIVERSITY
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