Application of gypensapogenin A to anti-tubercle bacillus drugs

An anti-tuberculosis and drug technology is applied in the application field of preparing anti-tuberculosis drugs, and achieves the effects of strong tuberculosis inhibitory activity, outstanding substantive characteristics and broad application prospects.

Active Publication Date: 2013-01-16
南通三聚知识产权服务有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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  • Application of gypensapogenin A to anti-tubercle bacillus drugs
  • Application of gypensapogenin A to anti-tubercle bacillus drugs
  • Application of gypensapogenin A to anti-tubercle bacillus drugs

Examples

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Embodiment 1

[0016] Embodiment 1: the preparation of the compound Gypensapogenin A tablet involved in the present invention:

[0017] Take 20 grams of compound Gypensapogenin A, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tabletting machine.

Embodiment 2

[0018] Embodiment 2: The preparation of the compound Gypensapogenin A capsules involved in the present invention:

[0019] Get 20 grams of compound Gypensapogenin A, add conventional auxiliary materials such as starch 180 grams for the preparation of capsules, mix well, and pack into capsules to make 1000 tablets.

[0020] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0021] Experimental example 1 Determination of absolute concentration of Gypensapogenin A against BCG by solid medium dilution method

[0022] Scrape the BCG culture from the slant, add it to 3ml Middlebrook7H9 broth medium, add a small amount of glass beads, tighten the test tube cap, vibrate and grind vigorously on the vortex oscillator, and compare it with the standard McFarland turbidimetric tube (MacFarland No.1 ) turbidity, that is, to prepare 1mg / ml bacillus Calmette-Guerin (BCG) bacterial suspension.

[0023] Make Gypensapogenin A into a high-concentration stock solution with DMSO, dilute the stock solution to the required concentration with 5% Tween-80 sterile ultrapure water, and add the diluted Gypensapogenin A to 4ml Middlebrook7H11 agar medium according to the required dose (The medium has been sterilized by high pressure steam at 121°C for 15 minutes, cooled to 50~55°C), mixed evenly to make Gypensapogenin A, the concentrations are 6.0 ug / ml, 4.0 ug / ml, 3.0 ug / ml...

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Abstract

The invention discloses application of gypensapogenin A to preparation of anti-tubercle bacillus drugs. According to the high tubercle bacillus morbidity and the emergence of mycobacterium tuberculosis multiple-resistant strain, the tubercle bacillus morbidity and mortality are one the rise; and gypensapogenin A has remarkable tubercle bacillus suppression activity and good application prospect. The application of gypensapogenin A to the preparation of the anti-tubercle bacillus drugs is firstly publicized, the skeleton type is brand-new, the tubercle bacillus suppression activity is unexpectedly strong and the possibility of giving any revelation by other compounds does not exist, so that prominent substantive features are provided and a remarkable progress in the prevention and treatment of the tubercle bacillus infection is made at the same time.

Description

technical field [0001] The invention relates to the application field of pharmaceutical compounds, in particular to the application of Gypensapogenin A in the preparation of anti-tuberculosis drugs. Background technique [0002] In recent years, the incidence of tuberculosis in the world has shown an increasing trend. According to the World Health Organization (WHO) estimates, the population infected by Mycobacterium tuberculosis (MTB) accounts for one-third of the world's population, of which 5-10% Infected people become TB patients. There are 1.3 million cases of active tuberculosis patients in my country every year, including about 600,000 cases of infectious tuberculosis, and about 600,000 cases of infectious tuberculosis. It is one of the countries with a high burden of tuberculosis in the world. [0003] Since the advent of anti-tuberculosis drugs one after another, the treatment of tuberculosis has played an epoch-making change. However, due to the irregular treatme...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/58A61P31/06
Inventor 俞骁王慧吴俊华
Owner 南通三聚知识产权服务有限公司
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