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Application of Houttuynoid C in antibacterial medicine

An antibacterial and drug technology, applied in the field of Houttuynoid C, can solve the problems of digestive tract irritation, strong accumulation of toxicity, etc.

Active Publication Date: 2013-01-16
如东文园投资开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The spread of pathogenic bacteria and the enhancement of drug resistance seriously threaten human health and life. Antibacterial drugs have been widely used as routine drugs in the treatment of AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) Treatment, although antibacterial agents currently used clinically (such as ketoconazole, amikacin, gentamicin, vigorconazole, itraconazole, terbinafine, amphotericin, fluconazole, etc.) The curative effect on skin and superficial infection is good, but these antibacterial drugs have strong cumulative toxicity, often causing liver and kidney damage, gastrointestinal irritation, dizziness, allergies, etc. one of the hotspots

Method used

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  • Application of Houttuynoid C in antibacterial medicine
  • Application of Houttuynoid C in antibacterial medicine
  • Application of Houttuynoid C in antibacterial medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1: Preparation of compound Houttuynoid C tablets involved in the present invention:

[0013] Take 20 grams of compound Houttuynoid C, add 180 grams of conventional excipients for tablet preparation, mix well, and conventionally press to form 1,000 tablets.

Embodiment 2

[0014] Example 2: Preparation of the compound Houttuynoid C capsule of the present invention:

[0015] Take 20 grams of compound Houttuynoid C, add 180 grams of conventional auxiliary materials for preparing capsules, such as 180 grams of starch, mix well, and encapsulate to make 1000 tablets.

[0016] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example

[0017] Experimental example: Houttuynoid C antibacterial activity

[0018] The antibacterial activity experiment adopts the concentration dilution method, and each measurement is repeated three times. The test pathogens include Escherichia coli, Pseudomonas fluorescens, Staphylococcus aureus, Proteus, Cryptococcus neoformans, and the concentration of the bacterial solution is 10 5 Pieces / mL. The initial concentration of Houttuynoid C is 50.0 μg / mL (5% dimethyl sulfoxide DMSO), and the gradient is diluted to 0.098 μg / mL. The same volume of bacterial liquid and test sample are mixed and cultured in a 96-well plate. The bacterial culture temperature is respectively It is 37°C and observed after 24 hours of incubation. If no colony is found, it is the lowest antibacterial concentration of the sample, that is, the MIC value. The positive control of this experiment is amikacin sulfate, and the antibacterial results of Houttuynoid C are shown in Table 1.

[0019] Table 1 Houttuynoid C an...

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PUM

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Abstract

The invention relates to application of Houttuynoid C in preparing an antibacterial medicine, belonging to the field of medicines. The Houttuynoid C has a strong effect on suppressing escherichia coli, pseudomonas fluorescens, staphylococcus aureus, proteusbacillus vulgaris and cryptococcus neoformans, thus the Houttuynoid C can be used as an antibacterial compound and is expected to be used in preparing related medicines. The application of Houttuynoid C in preparing an antibacterial medicine is disclosed for the first time; and since the skeleton type is a brand new one and the activity in suppressing bacterial activity is unexpectedly strong, the possibility of any other compound offering any inspiration does not exist, outstanding substantial characteristics are obtained, and an obvious progress is made in preventing and treating bacterial infection.

Description

Technical field [0001] The present invention relates to the use of Houttuynoid C, in particular to the application of Houttuynoid C in the preparation of antibacterial drugs. Background technique [0002] The spread of pathogenic bacteria and the enhancement of their drug resistance are a serious threat to human health and life. Antibacterial drugs have been widely used as routine drugs for AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) Treatment, although the current clinical use of antibacterial agents (such as ketoconazole, amikacin, gentamicin, viviconazole, itraconazole, terbinafine, amphotericin, fluconazole, etc.) It has a good effect on skin and superficial infections, but these antibacterial drugs have strong accumulated toxicity and often cause liver and kidney damage, digestive tract irritation, dizziness, allergies, etc., so the search for new antibacterial drugs with unique mechanisms of action has become today's dru...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P31/04
CPCY02A50/30
Inventor 朱磊磊龚霞吴俊华
Owner 如东文园投资开发有限公司
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