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Compound prepared by probiotic-fermented traditional Chinese medicine (TCM) preparation as well as preparation method and application of compound

A technology of traditional Chinese medicine preparations and probiotics, which is applied in the direction of drug combination, application, food preparation, etc., to reduce the concentration of ethanol, reduce the redness of the head and face, and improve the effect of excessive drinking

Active Publication Date: 2013-02-20
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no safe and reliable composition that can reduce alcohol toxicity and have a recovery effect on alcohol-induced liver damage

Method used

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  • Compound prepared by probiotic-fermented traditional Chinese medicine (TCM) preparation as well as preparation method and application of compound
  • Compound prepared by probiotic-fermented traditional Chinese medicine (TCM) preparation as well as preparation method and application of compound
  • Compound prepared by probiotic-fermented traditional Chinese medicine (TCM) preparation as well as preparation method and application of compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: Preparation of a composition with anti-alcoholic and liver-protecting effects by using probiotic mixed fermented traditional Chinese medicine preparations

[0026] 1. Compatibility and extraction of traditional Chinese medicine raw materials

[0027]White peony 50g, astragalus 20g, chuanxiong 20g, Hovenia dulcis 50g, kudzu flower 50g, angelica 20g, cinnamon 15g, dried ginger 10g, licorice 15g, add 1L water, decoct for about 40 minutes, filter off the medicine residue, and make decoction. Make up water to 1L, add 1% glucose, 0.5% yeast extract, 0.5% maltooligosaccharide, and adjust the pH to 7.0 with NaOH. The resulting mixture was autoclaved at 121° C. for 15 minutes and used for the culture fermentation of probiotics.

[0028] 2. Probiotic seed culture

[0029] MRS medium and LB medium were autoclaved at 121°C for 15 minutes, and inoculated with Bifidobacterium bifidum (MRS), Lactobacillus acidophilus (MRS) and Bacillus subtilis (including Bacillus natto)...

Embodiment 2

[0032] Embodiment 2: the anti-alcoholic effect of the composition of the present invention on alcoholism mice

[0033] 1. The effect of probiotic mixed fermented traditional Chinese medicine preparation composition on the time and rate of drunkenness in mice with acute alcoholism

[0034] Healthy male Kunming mice (Experimental Animal Center of Shandong University), weighing 20-25g. The mice were randomly divided into 2 groups: the model group (fed with equal volume of normal saline), and the administration group (fed with the fermentation broth composition 15 mL / kg body weight), 20 in each group. The mice in each group were fasted for 12 hours, and each treatment group was administered once. After 30 minutes, each group was given 56° Red Star Erguotou wine at 15 mL / kg body weight. Observe and record the drunken time of the mice (from sobriety to the time when the righting reflex disappears). If the animal's back-down posture was maintained for more than 30 s, it was conside...

Embodiment 3

[0045] Embodiment 3: Human body trial food test of probiotic mixed fermented Chinese medicine preparation composition

[0046] 1. The effect of probiotic mixed fermented traditional Chinese medicine preparation composition on blood ethanol content of subjects

[0047] Select 40 voluntary subjects aged 18-65, all male, and randomly divide them into 2 groups, 20 people in the test group and 20 people in the control group. Qualified. Test group: take probiotics mixed fermented traditional Chinese medicine preparation composition, take 50mL 15 minutes before drinking; control group: take normal saline, take 50mL 15 minutes before drinking. Please see Table 4.

[0048] Each subject drank 50mL of 56°Red Star Erguotou wine (completed within 5 minutes), and 2 hours later, the ethanol content in human blood was measured by gas chromatography.

[0049]

[0050] The results show that the probiotic mixed fermented traditional Chinese medicine composition can significantly reduce the...

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Abstract

The invention discloses a compound prepared by probiotic-fermented traditional Chinese medicine (TCM) preparation as well as a preparation method and application of the compound. The compound takes a culture solution containing crude TCM drugs such as astragalus, semen hoveniae, flower of kudzuvine, radix paeoniae alba and ligusticum wallichii, and takes fermentation liquor fermented by probiotics, such as bifidobacterium bifidum, lactobacillus acidophilus and bacillus subtillis, as an effective ingredient. The compound disclosed by the invention can be used for promoting ethanol metabolism in the liver, lowering ethanol concentration in blood, enhancing the endurance capacity of a human body to alcohol, and alleviating discomforts of head and face redness, dizziness and the like caused by alcohol. Foods and healthcare foods prepared by the compound disclosed by the invention can be taken as safe and reliable anti-alcoholic products for preventing and alleviating excessive drinking.

Description

technical field [0001] The invention relates to the technical field of biological fermentation, in particular to a composition with anti-alcoholic and liver-protecting effects. The composition uses traditional Chinese medicine raw materials such as astragalus, Hovenia dulcis, and kudzu flower as a culture solution, and is passed through Bifidobacterium bifidum , Lactobacillus acidophilus and Bacillus subtilis (including Bacillus natto) fermented with probiotics as active ingredients. Background technique [0002] Due to historical and cultural reasons, wine has had an indissoluble bond with people's daily life. Drinking a small amount of alcohol can promote metabolism, promote blood circulation and relax tendons, increase appetite, and eliminate fatigue; but excessive drinking can cause chronic ethanol poisoning, mucosal damage, myocardial fatigue, brittle blood vessels, and decreased respiratory system defense function. Symptoms such as renal failure can cause serious dama...

Claims

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Application Information

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IPC IPC(8): A23L1/29A61K36/9068A61K35/74A61P1/16A23L33/00A61K35/741
Inventor 谷劲松綦翠华张玉刘晖
Owner UNIV OF JINAN
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