13 results about "Ethanol metabolism" patented technology

The invention belongs to the technical field of medicines, and particularly relates to a plant lactobacillus for relieving acute alcoholic liver injury as well as a metagen and application of the plant lactobacillus. The strain of the plant lactobacillus L5-13 is preserved in the China Center for Type Culture Collection on August 18, 2025, and the preservation number of the strain is CCTCC NO: M 20251835. The strain and the metagen thereof can significantly improve pathological symptoms of mice with acute alcoholic liver injury, including: reducing the levels of ALT, AST, TC, TG and LDL-C in serum of the mice with acute alcoholic liver injury, and increasing the level of HDL-C; the abnormal blood lipid level of the mouse caused by acute alcohol is regulated; the activity of antioxidant enzymes in the liver is improved, and the lipid peroxidation level is reduced; the ethanol dehydrogenase activity of the liver is improved, and the ethanol metabolism capability is enhanced. Therefore, the strain and the metagen thereof have wide application prospects in prevention or treatment of acute alcoholic liver injury.

The invention discloses a rosa roxburghii tratt fruit composite beverage with a hangover alleviating effect and a preparation method and application thereof, and belongs to the technical field of biology. The roxburgh rose beverage disclosed by the invention comprises the following raw materials in parts by weight on the basis of 100 parts by weight: 8-16 parts of roxburgh rose concentrated juice, 5-15 parts of crystalline fructose, 0.8-2.5 parts of soybean peptide powder, 0.8-1.8 parts of yeast extract and the balance of water. Experiments prove that the formula product has the advantages of moderate taste, aromatic flavor, good stability and the like, and can keep stable taste and flavor during long-term storage. Animal experiments verify that the roxburgh rose beverage has an obvious hangover alleviating effect by improving ALDH activity, accelerating ethanol metabolism and reducing blood ethanol mass concentration, can improve liver injury caused by drinking by increasing liver SOD, GSH-Px, CAT activity and GSH content, reducing MDA content, enhancing body antioxidant ability and inhibiting lipid peroxidation reaction, and has a liver protection effect.

The invention provides application of lactobacillus brevicornu and a fermentation composition thereof in hangover alleviating and liver protection, and relates to the technical field of biological fermentation, the lactobacillus brevicornu is lactobacillus brevicornu, the strain number of the lactobacillus brevicornu is KMHD10-222, and the registration number of the lactobacillus brevicornu in the China General Microbiological Culture Collection Center is CGMCC No. 32358. Traditional Chinese medicine substrates can be fermented, and the hangover-alleviating and liver-protecting effects of fermentation products are enhanced. The content of rare ginsenoside, total polysaccharide, total flavone, total phenol, puerarin, daidzein and dihydromyricetin of the lactobacillus brevis KMHD10-222 fermentation substrate extracting solution is increased, the effects of promoting ethanol metabolism and improving the alcoholic liver disease can be improved, and the effects of dispelling the effects of alcohol and protecting the liver are achieved.

The invention discloses application of elaeagnus angustifolia polysaccharide in preparation of a product for preventing and / or treating alcoholic liver injury, and belongs to the technical field of polysaccharide. The invention provides an application of elaeagnus angustifolia polysaccharide in preparation of a product for preventing and / or treating alcoholic liver injury, which verifies the prevention / treatment effect of the elaeagnus angustifolia polysaccharide on the alcoholic liver injury by adopting a mouse alcoholic liver injury model through pathological histological observation, liver function indexes, oxidative stress indexes, inflammatory factors and ethanol metabolism related enzymes. Results show that the elaeagnus angustifolia polysaccharide can improve the level of enzymes related to alcohol metabolism, improve redox imbalance caused by alcoholic liver injury, enhance the antioxidant ability of a body and relieve inflammatory injury of liver tissues by regulating and controlling an NF-kappa B pathway and regulating oxidative stress related indexes, inhibit overexpression of inflammatory factors, improve the level of enzymes related to alcohol metabolism, and can be used for preventing and treating liver injury. Therefore, the toxic effect of alcohol on the liver is remarkably reduced, and the effect of preventing and / or treating the alcoholic liver injury is achieved.

The invention provides cordyceps militaris corn peptide fermentation liquor as well as a preparation method and application thereof, and belongs to the technical field of corn peptide deep processing. The preparation method of the cordyceps militaris corn peptide fermentation liquor comprises the following steps: firstly, performing enzymolysis on a corn peptide powder solution by adopting alpha-amylase, and then adding saccharifying enzyme for performing enzymolysis to obtain enzymatic hydrolysate; glucose is added into the enzymatic hydrolysate, the pH is adjusted to be 5-7, then cordyceps militaris C.LSG-1 is added for fermentation, and cordyceps militaris corn peptide fermentation liquor is obtained. The corn peptide is subjected to enzymolysis treatment, so that the utilization efficiency of the raw materials in a fermentation system is improved, and subsequent cordyceps militaris fermentation can be smoothly carried out; cordyceps militaris is utilized to ferment corn peptide, so that the flavor is improved, and the functional characteristics of the corn peptide can be enhanced and improved. An in-vivo model verifies that the cordyceps militaris corn peptide fermentation liquor prepared by the preparation method disclosed by the invention has better functions of promoting ethanol metabolism and preventing and treating alcoholic liver injury.

The invention relates to an anti-alcoholism composition, a liquid preparation with an anti-alcoholism effect and a preparation method and application of the liquid preparation, and belongs to the technical field of physiology. The anti-alcohol composition comprises an NAD (nicotinamide adenine dinucleotide) precursor substance and amino acid, and the NAD precursor substance is one or more of nicotinamide, nicotinamide ribose, nicotinamide mononucleotide or nicotinic acid; and the amino acid is one or more of L-glutamine, L-serine or L-lysine. The special combination of the NAD precursor substance and the amino acid can synergistically accelerate ethanol metabolism, and the alcohol effect dispelling liquid preparation prepared on the basis of the alcohol effect dispelling liquid preparation is flexible in use time, controllable in component and outstanding in alcohol effect dispelling effect, and has very wide application prospects.

The invention relates to the technical field of health food, and discloses a composition for sobering up, assisting in lowering lipid and improving intestinal tracts and a preparation method, the composition comprises the following components in parts by weight: 40-60 parts of rubus stems and leaves, 3-6 parts of oldenlandia diffusa, 1-3 parts of sculellaria barbata, 0.5-2 parts of balsam pear, 0.5-2 parts of radix bupleuri, 0.5-2 parts of pericarpium citri reticulatae, 0.5-2 parts of elecampane, 0.5-2 parts of raw hawthorn and 0.5-2 parts of semen plantaginis. The preparation method comprises the steps of raw material crushing, enzymolysis extraction, alcohol extraction, water extraction, spray drying and the like. Experimental verification shows that the composition has multiple effects of prolonging the drunkenness latency period, accelerating ethanol metabolism, reducing serum transaminase, regulating blood lipid indexes, improving intestinal peristalsis and flora structures and the like, and acute toxicity tests prove that the composition is high in edible safety. The composition disclosed by the invention can be used for preparing health-care foods with the effects of dispelling the effects of alcohol, assisting in lowering lipid and improving intestinal functions.

The invention belongs to the technical field of biological medicine, and particularly discloses a water-soluble pachymaran composition and application thereof in alcohol metabolism regulation. The mass concentration ratio of the water-soluble pachymaran to the kudzuvine root extract is 1: (1-2), the substitution degree of the water-soluble pachymaran is 0.6-0.7, the kudzuvine root extract is an ethanol extract of kudzuvine root powder, and the water-soluble pachymaran and the kudzuvine root extract play a synergistic role in regulating alcohol metabolism. On one hand, by promoting the functions of enzymes related to ethanol metabolism, the ethanol metabolism and removal efficiency is improved; on the other hand, the adverse effects of alcohol and metabolites thereof on the body are reduced by relieving inflammation and stress response accompanied by alcohol metabolism, so that a good overall effect is shown in the aspects of detoxification and alcohol metabolism regulation. The water-soluble pachymaran composition provided by the invention has the effect of improving the physiological status after alcohol intake, and has a wide application prospect in the fields of hangover alleviating and alcoholic injury protection.

The invention relates to the technical field of health-care food, and particularly discloses a fermented beverage for relieving discomfort after drinking and a preparation method and application thereof.The fermented beverage comprises pomegranate seed extract and medicated leaven prepared through fermentation of composite yeast seeds containing aspergillus oryzae and saccharomyces cerevisiae, the pomegranate seed extract is pomegranate polyphenol extract, and in the pomegranate polyphenol extract, aspergillus oryzae and saccharomyces cerevisiae are added into the fermented beverage; the total polyphenol content is not lower than 40%, the resveratrol content is not lower than 1.5%, the fermented beverage further comprises malt, a malt extract, hovenia dulcis thunb, edible yeast, a radix puerariae extract and a radix puerariae flower extract, and the prepared fermented beverage is applied to food or health care products for accelerating ethanol metabolism in blood and relieving dizziness, nausea or weakness and discomfort after drinking. The product is stable in efficacy and suitable for preparing food or health care products with the hangover alleviating function.

The inactivated lactic acid bacteria and the metagen thereof disclosed by the invention can be used for preparing a product for inhibiting helicobacter pylori. Besides, the pediococcus acidilactici Lab2 metagen and the acetobacter aceti AS1.41 metagen are compounded, it is found that compounding of the pediococcus acidilactici Lab2 metagen and the acetobacter aceti AS1.41 metagen is remarkably higher than that of single Lab2 metagen or acetobacter aceti metagen, and in the ethanol metabolism level, the compound metagen remarkably improves ADH and ALDH activity of the mouse liver. Secondly, on the oxidative stress regulation level, the SOD, CAT activity and GSH content of the mouse liver are remarkably improved by compounding the metabiotics, and meanwhile, the MDA level is reduced. In the aspects of liver function protection and lipid metabolism regulation, the compound metabiotics can significantly reduce the activity of ALT and AST in serum, and can significantly reduce the level of TG and TC in serum at the same time. The liver tissue pathological section further proves that the composite metagen can obviously relieve hepatocyte edema and microvesicle fatty degeneration, recover normal structural arrangement of the liver tissue and realize comprehensive protection on the alcoholic acute liver injury.

The invention discloses a nanometer platform based on manganese prussian blue nanometer enzyme and acetobacter aceti as well as a preparation method and an application method of the nanometer platform. The nano-platform is obtained by mixing a manganese prussian blue nano-enzyme solution and acetobacter aceti, wherein the ratio of manganese prussian blue nano-enzyme to acetobacter aceti is 1 * 10 < 8 > (CFU / mL): (25-400) (g / mL). The acetobacter aceti is cultured by ethanol, and growth and ethanol metabolism are optimized. According to the manganese prussian blue nano-enzyme, the structure stability and dispersity are optimized by adjusting the proportion of manganese and iron precursors. The nano platform can be used for preparing oral medicines for preventing and treating acute alcoholic liver injury, or can be used as an imaging contrast agent of MRI (Magnetic Resonance Imaging) for observing gastrointestinal tract distribution. The nano platform has the advantages of simple preparation process, wide application range, good imaging performance, excellent oxidation resistance, small toxic and side effects and the like, and can realize efficient ethanol metabolism regulation and anti-oxidation protection.

This invention provides the application of active peptides in the preparation of products for the prevention and treatment of ALD. The amino acid sequence of the active peptides of this invention is shown in SEQ ID NO:1. These peptides not only activate ADH and ALDH enzymes to promote ethanol metabolism, but also significantly scavenge DPPH and ABTS free radicals, exerting antioxidant effects, thereby effectively preventing and / or treating ALD. Therefore, they are highly suitable for the preparation of products for the prevention and treatment of ALD.