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Flat-plate type high-field asymmetric waveform ion mobility spectrometer with noise reduction function

A waveform ion migration and high-field asymmetry technology, which is applied in mass spectrometers, electron/ion optical devices, and parts of particle separator tubes, can solve problems such as deviation from actual values, large signal noise, and electromagnetic interference, and achieve Effects of reduced interference, ease of miniaturization, and ease of integration

Active Publication Date: 2013-02-27
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the above structures all have shortcomings: because the asymmetric waveform radio frequency voltage applied on the electrode in the migration region is a high-voltage high-frequency voltage, electromagnetic interference will be generated in the entire space; and the current detected by the current detection electrode is a picoampere A weak signal of magnitude, this signal is very susceptible to interference by asymmetric waveform RF voltage, resulting in a large noise in the final detected signal, which deviates from the actual value

Method used

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  • Flat-plate type high-field asymmetric waveform ion mobility spectrometer with noise reduction function
  • Flat-plate type high-field asymmetric waveform ion mobility spectrometer with noise reduction function
  • Flat-plate type high-field asymmetric waveform ion mobility spectrometer with noise reduction function

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Embodiment 1

[0032] A no-load comparison experiment was carried out using a flat-panel high-field asymmetric waveform ion mobility spectrometer with noise reduction function and a flat-panel high-field asymmetric waveform ion mobility spectrometer without noise reduction function. In the experiment, the carrier gas and the sample were not connected, and only the influence of the asymmetric waveform RF voltage on the current detection was observed. The asymmetric waveform RF power supply 9 generates an asymmetric waveform RF voltage with a frequency of 1 MHz and a duty cycle of 30%, which is applied to the electrode 6 in the upper transition region. The peak-to-peak value of the asymmetric waveform RF voltage gradually increases from zero, and the measured current value under the corresponding voltage is recorded at the same time. From the experimental results, the detection current of the flat-panel high-field asymmetric waveform ion mobility spectrometer without noise reduction function i...

Embodiment 2

[0038] In the Chinese patent "Ion focusing method for high-field asymmetric waveform ion mobility spectrometer with flat structure" (application number 201010619966.5) proposed by Tsinghua University, a design with noise reduction function is adopted, such as Figure 10 shown. A ring of transition region shielding electrodes 13 added around the upper transition region electrode 6 and a ring of current detection shielding electrodes 14 added around the current detection electrode 12 are grounded respectively. Since the upper transition zone electrode 6 is surrounded by the transition zone shield electrode 13, the current detection electrode 12 is surrounded by the current detection shield electrode 14, and the transition zone shield electrode 13 and the current detection shield electrode 14 are respectively grounded, then the upper transition zone electrode 6 A zero potential zone is formed around the current detection electrode 12 and the electric field line will not be able t...

Embodiment 3

[0040] The Chinese patent "Aggregation device and method for flat-plate high-field asymmetric waveform ion mobility spectrometer" (application number 20120211272.7) applied by Tsinghua University adopts a design with noise reduction function, such as Figure 11 shown. A ring of transition region shielding electrodes 13 added around the upper transition region electrode 6 and a ring of current detection shielding electrodes 14 added around the current detection electrode 12 are grounded respectively. Since the upper transition zone electrode 6 is surrounded by the transition zone shield electrode 13, the current detection electrode 12 is surrounded by the current detection shield electrode 14, and the transition zone shield electrode 13 and the current detection shield electrode 14 are respectively grounded, then the upper transition zone electrode 6 A zero potential zone is formed around the current detection electrode 12 and the electric field line will not be able to pass th...

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Abstract

The invention discloses a flat-plate type high-field asymmetric waveform ion mobility spectrometer with a noise reduction function, which comprises an ion source, a migration area and a detection unit, wherein an upper substrate and a lower substrate are arranged in the migration area in parallel; the upper substrate and the lower substrate are respectively provided with an upper migration area electrode and a lower migration area electrode; the upper migration area electrode is connected with an asymmetric waveform radio-frequency power supply and a direct-current scanning compensation power supply; and the detection unit consists of a current detection electrode and a current detection deflection electrode which are respectively arranged on the upper substrate and the lower substrate. The flat-plate type high-field asymmetric waveform ion mobility spectrometer with the noise reduction function is characterized in that one circle of migration area shielding electrode is additionally arranged on the periphery of the upper migration area electrode; meanwhile, one circle of current detection shielding electrode is additionally arranged around the current detection electrode; the two circles of shielding electrodes are respectively earthed; and the upper migration area electrode and the migration area shielding electrode as well as the current detection electrode and the current detection shielding electrode are insulated by air or insulating materials.

Description

technical field [0001] The invention relates to the determination of biochemical substances, belongs to the field of on-site analysis and detection, and is specifically a flat-plate high-field asymmetric waveform ion with a ring of shielding electrodes added around the migration region electrode and the current detection electrode and grounded to reduce signal detection noise. Migration spectrometer. Background technique [0002] High-field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS, High-field Asymmetric Waveform Ion Mobility Spectrometry) is a biochemical substance detection technology gradually developed in the 1990s. It mainly uses the characteristic that the mobility of ions under high electric field will be different with the change of electric field strength to separate and detect different kinds of substances. Its basic principle is as follows: under low electric field conditions, the mobility coefficient of ions has nothing to do with the electric field s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/26H01J49/06
Inventor 唐飞王晓浩徐初隆
Owner TSINGHUA UNIV
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