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Transdermal absorption preparation

An absorption enhancer and preparation technology, applied in nervous system diseases, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of high polarity and difficult percutaneous absorption, and achieve the effect of good skin permeability

Active Publication Date: 2013-02-27
ICURE PHARML CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In particular, hydrophilic drugs or drugs in the form of salts are more difficult to absorb through the skin than ordinary drugs due to their high polarity.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1~7

[0067] The same ingredients as in Examples 1 to 7 in Table 1 were put into 175 g of toluene and completely dissolved, and the dissolved solution was coated on a polyester film (thickness: 75 μm) coated with silicone resin, dried to a thickness of 110 μm, and laminated on poly Ester film (thickness: 12μm) completes the mount.

Embodiment 8~14

[0069] The same ingredients as in Examples 8 to 14 in Table 1 and Table 2 were put into 175 g of toluene and completely dissolved, and then the dissolved solution was coated on a polyester film (thickness: 75 μm) coated with silicone resin and dried to a thickness of 73 μm. The layer is finished in a polyester film (thickness: 12μm).

[0070] Table 1

[0071]

[0072]

[0073] Table 2

[0074]

[0075]

[0076]

[0077] Franz diffusion cell (effective area: 0.64cm 2 , the volume of the aqueous phase: ) under the effect of the sink (sink condition) under the skin penetration test. As the aqueous phase, phosphate buffered saline (Phosphatebuffered saline, PBS) with a pH value of 7.4 was used.

[0078] First, fill the Franz diffusion cell with water-soluble phase and maintain it at 32±0.5°C, then cut the sample into a circle (with an area of ​​0.64cm 2 ) was attached to the central part of the prepared skin (human cadaver skin epidermis), the skin with the sam...

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Abstract

The present invention relates to a transdermal absorption preparation. The transdermal absorption preparation of the present invention comprises a drug-containing adhesive layer, a drug-protective layer and a release layer, wherein the drug-containing layer contains ropinirole or a salt thereof, rubber, an adhesion-imparting resin, an antioxidant, and a transdermal absorption promoter. Also, the present invention provides a transdermal absorption preparation comprising a drug-containing adhesive layer, a drug-protective layer and a release layer, wherein the drug-containing layer contains ropinirole or a salt thereof, acrylic rubber, an anti-crystallization agent, and a transdermal absorption promoter.; When the transdermal absorption preparation of the present invention is used for the treatment of Parkinson's disease or restless leg syndrome, no side effect due to an increase in the initial concentration in blood occurs and the skin penetration effect of the drug is excellent.

Description

technical field [0001] The present invention relates to transdermal absorption preparations, more specifically, the present invention relates to a kind of percutaneous absorption preparations containing ropinirole or its salts for the treatment of neurological disorders, that is, there is no side effect of initial increase in blood concentration, and it is ropinirole. A transdermal preparation having good skin permeability of pinirole or a salt thereof. Background technique [0002] Ropinirole is a dopamine receptor agonist selective for D2 dopamine receptors and a dopamine receptor agonist with high affinity for D3 dopamine receptors. Ropinirole is a dopamine receptor agonist that makes dopamine readily available. [0003] When oral administration is adopted for the drug delivery system of ropinirole, most side effects and inconveniences are caused. Typical side effects include fainting, lethargy, headache, vomiting, fatigue, indigestion, etc., which are considered to be ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/404A61P25/00
CPCA61K31/4045A61K9/7053A61K9/7061A61K9/7076A61P25/00A61P43/00
Inventor 崔永权金正铸金圣洙李廷植朴盛民
Owner ICURE PHARML CORP
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