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Drug composite for treating infantile eczema and preparation method thereof

A technology of children's eczema and composition, which is applied in the field of pharmaceutical composition and its preparation, can solve the problems of strong irritation, unfavorable development of children, large toxic and side effects, etc., and achieve remarkable effects without any side effects and clear effects

Inactive Publication Date: 2013-03-20
王恩瀚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(Asher MI, Montefort S, et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema infanthood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet, 2006, 368(9537): 733-743; McAleer MA, McAleer C , Irvine AD. Management of difficult and severe eczema in childhood. BMJ, 2012, 345: e4770; Foisy M, Boyle RJ, Chalmers JR, et al. Overview of reviews the prevention of eczema in infants and children: an overview of Cochrane and non- Cochrane reviews. Evid Based Child Health, 2011, 6(5): 1322-1339; Santer M, BurgessH, Yardley L, et al. Experiences of carers managing childhood eczema and their views on its treatment: a qualitative study. Br J Gen Pract , 2012, 62(597): e261-267) Although traditional treatment methods can play a relieving effect, antihistamines and hormone ointments are highly irritating and have large toxic and side effects, which are not good for the development of children, and some People may heal after puberty, but dry and itchy skin is usually lifelong and often accompanied by asthma, nasal allergies

Method used

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  • Drug composite for treating infantile eczema and preparation method thereof
  • Drug composite for treating infantile eczema and preparation method thereof
  • Drug composite for treating infantile eczema and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] At room temperature, take 10 kg each of Huanghua Shuidaolian, Qingtian Kui, Fei Yangcao, Sophora flavescens, Houttuynia cordata and honeysuckle (60 kg in total), soak and extract with 600 kg of ethanol with a volume concentration of 70%, and soak for 24 hours , the residue is then soaked in 600 kg of ethanol with a volume concentration of 70% for 24 hours to extract, then the soaked solutions are combined, filtered through a 200-mesh filter, concentrated 20 times under reduced pressure, and then the concentrated solution is covered with a macroporous resin, and the concentrated solution is used for volume The ethanol with a concentration of 50% is used for eluting, and the collected eluate contains the active ingredients required in the prescription of the present invention, that is, the pharmaceutical composition.

Embodiment 2

[0043] At room temperature, take 8 kg of Shuidaolian, 8 kg of Qingtiankui, 8 kg of Feiyangcao, 12 kg of Sophora flavescens, 12 kg of Houttuynia cordata and 12 kg of honeysuckle (60 kg in total), and use 1200 kg of ethanol with a volume concentration of 50%. kg soaking extraction, soaking time is 24 hours, and the residue is soaked in 1200 kg of ethanol with a volume concentration of 50% for 24 hours to extract, then the soaked solutions are combined, filtered through a 200-mesh filter, concentrated 40 times under reduced pressure, and then The concentrated liquid is put on the macroporous resin, and is eluted with ethanol with a volume concentration of 40%, and the collected eluate contains the active ingredients required in the prescription of the present invention, that is, the pharmaceutical composition.

Embodiment 3

[0045] At room temperature, take 8 kg of Shuidaolian, 8 kg of Qingtiankui, 15 kg of Flyris, 15 kg of Sophora flavescens, 15 kg of Houttuynia cordata and 15 kg of honeysuckle (76 kg in total), and use 1000 kg of ethanol with a volume concentration of 80%. kg soaking extraction, soaking time is 24 hours, the residue is then soaked in 1000 kg of ethanol with a volume concentration of 80% for 24 hours to extract, then the soaked solutions are combined, filtered through a 200-mesh filter, concentrated 25 times, and then the concentrated solution is placed on the The macroporous resin is eluted with ethanol with a volume concentration of 60%, and the collected eluate contains the active ingredients required in the prescription of the present invention, that is, the pharmaceutical composition.

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Abstract

The invention provides a drug composite for treating infantile eczema and a preparation method thereof. The drug composite with an effect on treating infantile eczema is prepared from the following raw materials in parts by weight: 1-60 parts of citron day-lily walking spleenwort, 1-60 parts of nervilia fordii schltr, 1-60 parts of hairy euphorbia, 1-60 parts of radix sophorae flavescentis, 1-60 parts of houttuynia cordata and 1-60 parts of honeysuckle flowers. The drug composite provided by the invention has the advantages of obvious effect and safety on treating infantile eczema without stimulation or sensitization on skin.

Description

technical field [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a pharmaceutical composition for cosmetics with the effect of treating infantile eczema and a preparation method thereof, suitable for being added to ointments, creams, milks, liquids (except perfume ) cosmetics. Background technique [0002] Pediatric eczema is an allergic disease caused by a variety of internal and external factors. Sheets, diffuse edges, obvious edema, erosive surface formed after blister rupture, more exudate and yellow scabs, skin lesions come and go during the whole disease period, skin lesions often cause severe itching, due to scratching, often secondary bacteria Infection, if there is secondary infection, the local lymph nodes will be enlarged and there will be fever, which will seriously affect the quality of life of children. (Asher MI, Montefort S, et al. Worldwide time trends in the prevalence of symptoms of asthma,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/78A61P17/00
Inventor 王恩瀚
Owner 王恩瀚
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