Biosensor apparatuses and methods thereof

A technology of biosensors and equipment, applied in the field of biosensors, can solve the problems of unrealistic real-time results, unknown initial concentration, sacrificing measurement resolution, etc.

Active Publication Date: 2013-03-20
NTH TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, when incubating test samples, it may take a long time to obtain test results, real-time results are not practical, and measurement resolution is sacrificed since the initial concentration may be unknown

Method used

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  • Biosensor apparatuses and methods thereof
  • Biosensor apparatuses and methods thereof
  • Biosensor apparatuses and methods thereof

Examples

Experimental program
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Embodiment Construction

[0029] Figure 1A is a top view of an exemplary field effect transistor (FET) 20 having a gate 22 positioned and spaced offset from a channel region 24 . Figure 1B yes Figure 1A A perspective view of an exemplary FET 20 of FIG. FET 20 has source region 26 and drain region 28 separated by channel region 24 . In certain embodiments, source region 26, drain region 28, and channel region 24 are formed in a substrate (not shown). Non-limiting examples of FET 20 substrates may include silicon and gallium arsenide. Source region 26 and drain region 28 may include a first type of semiconductor, while channel region 24 may include a second type of semiconductor. Suitable types of semiconductors for forming source region 26, drain region 28, and channel region 24 are known to those skilled in the art and can be readily selected depending on the implementation.

[0030] Channel region 24 has a channel length along a length (L) axis and a channel width along a width (W) axis. exist ...

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Abstract

A biosensor has one or more field effect transistors each comprising a source region and a drain region separated by a channel region and a gate positioned offset and spaced from the channel region. The biosensor also has one or more molecular probes coupled to at least one of the channel region and the offset gate, the one or more molecular probes configured to mate with at least one target. A method for detection of a target is also disclosed. One or more targets are immobilized as an electric field shunt between an offset gate and a channel region for one or more biosensors. A target measurement value is determined in proportion to a number of the one or more biosensors having the electric field shunt.

Description

technical field [0001] The present technology relates generally to biosensors and, more particularly, to biosensors having a field effect transistor gate positioned offset from a channel region such that a sensor connected to the gate and / or or one or more molecular probes on the channel region are used as electric field shunts between the biased gate and the channel region. Background technique [0002] Applications such as the detection of diseases that lead to the production of pathogens in water place a high demand on sensors, especially those capable of sensing biological targets. Many types of sensors proposed for biological detection use technologies such as microfluidics, polymerase chain reaction (PCR) target amplification, piezoelectric materials, or ion-sensitive field-effect transistors (ISFETs). Unfortunately, many of these techniques require filtration and incubation of biological samples and are therefore not suitable for real-time monitoring of fluid conditi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/414G01N33/569G01N33/48
CPCG01N33/54373H01L29/66G01N27/4145
Inventor 迈克尔·波特
Owner NTH TECH
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